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Toads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piauí state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 µg mL-1) and prostate (IC50 = 1.6 µg mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 µg mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.

https://doi.org/10.21577/0103-5053.20230052

The influence of compositional variability of dimension stone residues on the properties of rustic porous ceramic tiles
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Prado, A. C. A.

; Feitosa, R. L. M.

; Neves, M. A.

; Taguchi, S. P.

Cerâmica

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jan 2023, Volume 69 N. 389 Pages 23 - 29

Abstract: En | Text: En | PDF: En

Abstract This study analyzed how the compositional variability of dimension stone residues influences the characteristics of rustic porous ceramic tiles. The specimens were prepared by adding 20 wt% of dimension stone residue to the clay and sintered at 1000 °C for 1 h. The testing assays performed were physical properties and structural analysis through scanning electron microscopy. The results indicate that water absorption was lower (~9% to 14%) in samples containing silicate residues compared to carbonate residues (~16%). Apparent porosity of ~21% to 25% and shrinkage of 0.5% to 1.6% were measured in silicate samples while higher apparent porosity of ~30% and expansion of -0.04% were found in carbonate samples. Flexural strength and modulus of rupture were similar, ~16 MPa and ~330 N, respectively, for both sample sets. The samples containing silicate residues whose SiO2 content was between 48% and 58% and the sum of alkaline and alkaline earth oxides was less than 18% were suitable for manufacturing rustic porous ceramic tile, while residues with high SiO2 or carbonate contents impaired the properties of the ceramic bodies. Therefore, it is recommended that the dimension stone residues intended for use in ceramic tiles be previously separated according to chemical and mineralogical characteristics.

https://doi.org/10.1590/0366-69132023693893382

Antioxidants and cardioprotective effects of ethyl acetate fraction of Canavalia rosea leaves in myocardial ischemia-reperfusion injury
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FEITOSA, MARAÍSA B.J.

; ARAÚJO, SILVAN S.

; MESQUITA, THÁSSIO RICARDO R.

; GIODA, CAROLINA R.

; SÁ, LUCAS A. DE

; ALMEIDA, GRACE KELLY M.

; MIGUEL-DOS-SANTOS, RODRIGO

; BARBOSA, ANDRIELE M.

; VASCONCELOS, CARLA MARIA L. DE

; CAMARGO, ENILTON A.

; BARREIROS, ANDRÉ LUÍS B.S.

; ESTEVAM, CHARLES S.

; MORAES, ÉDER RICARDO DE

; AMARAL, RICARDO G.

; LAUTON-SANTOS, SANDRA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Suppl. 1 elocation e20220514

Abstract: En | Text: En | PDF: En

Abstract Different degrees in the biological activities of Canavalia rosea had been previously reported . In this study, our group assessed the cardioprotective effects of the ethyl acetate fraction (EAcF) of the Canavalia rosea leaves. Firstly, it was confirmed, by in vitro approach, that the EAcF has high antioxidant properties due to the presence of important secondary metabolites, as flavonoids. In order to explore their potential protector against cardiovascular disorders, hearts were previously perfused with EAcF (300 μg.mL-1) and submitted to the global ischemia followed by reperfusion in Langendorff system. The present findings have demonstrated that EAcF restored the left ventricular developed pressure and decreased the arrhythmias severity index. Furthermore, EAcF significantly increased the glutathiones peroxidase activity with decreased malondialdehyde and creatine kinase levels. EAcF was effective upon neither the superoxide dismutase, glutationes reductase nor the catalase activities. In addition, the Western blot analysis revealed that ischemia-reperfusion injury significantly upregulates caspase 3 protein expression, while EAcF abolishes this effect. These results provide evidence that the EAcF reestablishes the cardiac contractility and prevents arrhythmias; it is suggested that EAcF could be used to reduce injury caused by cardiac reperfusion. However more clinical studies should be performed, before applying it in the clinic.

https://doi.org/10.1590/0001-3765202320220514

Stable and Thermo-Responsive Dextran Sulfate-Graft-PNIPAm Amphiphilic Nanoparticles for Potential Target Methotrexate Delivery
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Santos, Aline T. dos

; Silva, Emerson L. da

; Montenegro, Raquel C.

; Sousa, Jeanlex S. de

; Paula, Regina C. M. de

; Feitosa, Judith P. A.

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 9 Pages 1262 - 1272

Abstract: En | Text: En | PDF: En

Thermo-responsive copolymers grafted with N-isopropylacrylamide (NIPAm) are excellent candidates for drug release. Dextran sulfate (DS) acts as a specific ligand in inflamed regions, turning it highly useful as a target for drug delivery. DS was associated with NIPAm to produce amphiphilic graft copolymers prepared via free radicals. The molar ratio of feed reagents NIPAm/DS varied from 1 (DS-g-PNIPAm) to 4 (DS-g-4PNIPAm). The synthesis was confirmed by spectroscopic techniques (Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR)). All copolymers showed self-organization capacity in an aqueous medium in temperatures higher than 34 °C, and sizes less than 300 nm. DS-g-3PNIPAm exhibited stability in water and in phosphate buffer at pH 7.4. Scanning electron microscopy confirmed their spherical shape. This copolymer showed specificity to leukemic cells, and normal cells’ proliferation. Methotrexate (MTX) is a very low water-soluble drug used for rheumatoid arthritis and cancer. Unfortunately, MTX have severe collateral effects. MTX-loaded nanoparticles can overcome such issues as well as enhance bioactivity and stability. The MTX was encapsulated and delivered from the DS-g-3PNIPAm with potential target delivery due to the presence of DS. Comparison with MTX encapsulated in other nanoparticles reveals that the DS-g-PNIPam presents the best performance among the thermo-responsive and the second among the target MTX nanocarriers.

https://doi.org/10.21577/0103-5053.20230037

Structural, Thermal and Magnetic Characterization of Polycrystalline Ni-Mn-Ga Ferromagnetic Shape Memory Alloys
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Batista, K. V.

; Quirino, J. M.

; Souto, C. R.

; Feitosa, F. R.

; Gomes, R. M.

; Guedes, B.

; Júnior, F. W. E. L. A.

Materials Research

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2023, Volume 26 elocation e20230201

Abstract: En | Text: En | PDF: En

Shape memory alloys (SMA) are now widely studied in academia and have increasing usage in industry, as they allow efficient performance compared to mechanic actuators with reduced dimensions and the possibility of sensing temperature through the material itself. A subclass of the SMAs are the alloys with magnetic shape memory, still little explored as intelligent materials in Brazil. They combine the best properties of SMAs and common magnetostrictive materials. The magnetic shape memory alloys (MSMA) can be activated not only by the presence of a thermal stimulus, but also by the presence of an applied magnetic field. In this research, the polycrystalline magnetic shape memory alloys Ni51.3Mn24Ga24.7 and Ni54Mn21Ga25 were manufactured and characterized. Differential scanning calorimetry, X-Ray diffraction, energy dispersive X-ray spectrometry and scanning electron microscopy analyzes were performed to thermoanalytically and crystallographically characterize the alloys. Magnetic characterizations were also performed using Magnetic force microscopy. The results of the characterizations showed that the production process and the heat treatment were satisfactory for the fabrication of the ferromagnetic polycrystalline alloys. Besides that, the compositions Ni51.3Mn24Ga24.7 and Ni54Mn21Ga25, presented austenitic and martensitic 5M structures, respectively, at room temperature and it was possible to observe the alignment of the magnetic domains after magnetization.

https://doi.org/10.1590/1980-5373-mr-2023-0201

Larvicidal activity of vegetable oils against Aedes aegypti larvae
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Azevedo, Francisco Roberto de

; Bezerra, Lays Laianny Amaro

; Silva, Toshik Iarley da

; Silva, Renato Augusto da

; Feitosa, José Valmir

Revista Facultad Nacional de Agronomía Medellín

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may 2021, Volume 74 N. 2 Pages 9563 - 9570

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Aedes aegypti L. es el mosquito que transmite el virus de la fiebre amarilla, el dengue, el zika y el chikungunya. La prevención y el control de tales enfermedades generalmente dependen del uso de productos químicos, que causan daños al hombre y al medio ambiente. Por ello, los aceites vegetales con acción larvicida se utilizan como alternativa para controlar este insecto. El objetivo de este trabajo fue evaluar el potencial larvicida de aceites vegetales de Caryocar coriaceum, Mauritia flexuosa, Carapa guianensis, Copaifera langsdorffii, Ricinus communis y Cocos nucifera contra A. aegypti. El experimento se dividió en dos bioensayos. En el primero se realizó un diseño completamente al azar con siete tratamientos (seis aceites vegetales a 500 ppm y un control y cuatro repeticiones). Se evaluó el número de larvas muertas a las 24, 48, 72, 96 y 120 h de exposición. En el segundo bioensayo, se utilizaron los aceites vegetales más eficientes (C. coriaceum y M. flexuosa) en concentraciones 0, 500, 1000, 1500, 2000 y 2500 ppm, con cuatro repeticiones. El número de larvas muertas se evaluó según el primer bioensayo. Todos los aceites utilizados tienen efecto larvicida sobre larvas de A. aegypti de tercer estadio, con mayor eficacia a las 120 h de exposición. Los aceites de C. coriaceum y M. flexuosa mostraron mejor eficacia en el control de larvas, siendo la dosis de 2500 ppm la más recomendada. El LD10, LD50 y LD90 del aceite de M. flexuosa recomendado para controlar larvas son 234, 648 y 1794 ppm, respectivamente.

ABSTRACT Aedes aegyptiL. is the mosquito vector of yellow fever, dengue, zika, and chikungunya viruses. The prevention and control of such diseases usually rely on the use of chemicals, that can cause harm to human health and the environment. Vegetable oils with larvicidal activity are used as an alternative tool to control this insect. This study aimed to evaluate the larvicidal activity of vegetable oils fromCaryocar coriaceum,Mauritia fIexuosa,Carapa guianensis, Copaifera langsdorffii, Ricinus communisandCocos nuciferaagainstA. aegypti larvae. The experiment was divided into two bioassays. In the first, a completely randomized design was used with seven treatments (six vegetable oils at 500 ppm and one control with four replications). The number of dead larvae was evaluated 24, 48, 72, 96, and 120 h after exposure. In the second bioassay, the most efficient vegetable oils from the first bioassay (C. coriaceumandM. flexuosa) were used at the concentrations of 0, 500, 1000, 1500, 2000, and 2500 ppm, with four replications. The number of dead larvae was evaluated according to the first bioassay. All oils used had larvicidal activity on third-instar stage larvae ofA. aegypti, with greater efficiency 120 h after exposure. The oils ofC. coriaceumandM. flexuosaat 2500 ppm had the best efficacy in the larvae control. The LD10, LD50, and LD90 ofM. flexuosaoil recommended for controlling larvae are 234, 648, and 1794 ppm, respectively.

https://doi.org/10.15446/rfnam.v74n2.91486 118 downloads

Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation
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Silva, Ivan S.

; Feitosa, Eduardo L.

; Santos, Márcio E. P.

; Silva, Raiane M.

; Rocha, Márcio S.

; Silva, Francisco I. da

; Lima, Francisco C. A.

; Costa, Ana Maria S.

; Alves, Péricles B.

; Sousa, Samuel A. A. de

; Oliveira, Aldeídia P.

; Lima, Sidney G. de

Journal of the Brazilian Chemical Society

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may 2020, Volume 31 N. 5 Pages 1064 - 1077

Abstract: En | Text: En | PDF: En

In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (using a spray drier) and characterized making use of spectroscopic, thermal and computational methods. In addition, the system was evaluated regarding its vasorelaxant properties. Evidence of the inclusion complex formation was provided using different techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies and then deduced by pharmacological experiments, which showed significant changes in relation to the initial material.

https://doi.org/10.21577/0103-5053.20190273 403 downloads

Analysis of the global tall buildings stability in flat slabs considering the soil structure interaction
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ALVES, E. C.

; FEITOSA, L. A.

Revista IBRACON de Estruturas e Materiais

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feb 2020, Volume 13 N. 1 Pages 183 - 199

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A estabilidade global de edifícios altos de concreto armado formados por lajes planas é garantida, entre outros fatores, pela existência de elementos consideravelmente rígidos, como os núcleos de elevadores e regiões das escadas. Tais núcleos rígidos apresentam recorrentemente o formato de “L” ou “U” por se adequarem melhor ao projeto arquitetônico. No entanto, deve-se ressaltar a considerável relevância e influência da rigidez à flexão transversal das lajes na estabilidade da edificação. As lajes atuam em conjunto com os pilares na estabilidade do edifício, no denominado efeito de diafragma rígido. Ou seja, elas compatibilizam os deslocamentos horizontais em cada pavimento e promovem uma restrição parcial ao empenamento dos núcleos rígidos e ao giro das extremidades dos pilares, reduzindo assim os deslocamentos horizontais e os efeitos de 2ª ordem. Em contraponto à rigidez à flexão transversal das lajes, deve-se ressaltar a importância da consideração da interação solo-estrutura (ISE) na estabilidade das edificações. Em edifícios formados por lajes planas a ISE ganha uma relevância considerável, devido às suas características, isto é, tais edificações são particularmente sensíveis às influências da interação solo-estrutura. Neste trabalho dá-se ênfase à influência da rigidez à flexão transversal das lajes e à Interação Solo-Estrutura na análise e verificação da estabilidade global de edifícios de múltiplos andares formados por lajes planas e núcleos rígidos.

Abstract The global stability of tall reinforced concrete buildings made up of flat slabs is guaranteed, among other factors, by the existence of considerably rigid elements such as elevator cores and stairways. Such rigid cores recurrently have the "L" or "U" format because they fit the architectural design better. However, it should be emphasized the considerable relevance and influence of the slabs transversal bending stiffness in the building stability. The slabs act in conjunction with the columns in the building stability, in the so-called rigid diaphragm effect. That is, they combine the horizontal displacements in each floor and promote a partial restriction to the warping of the rigid cores and the rotation of the ends of the columns, thus reducing the horizontal displacements and the effects of 2nd order. In contrast the slabs transversal bending stiffenes, it should be emphasized the importance of considering the soil-structure interaction (ISE) in the buildings stability. In buildings formed by flat slabs ISE gains considerable relevance because of their characteristics, ie such buildings are particularly sensitive to the influences of soil-structure interaction. In this work, emphasis is placed on the influence of cross-bending rigidity on slabs and on Soil-Structure Interaction in the analysis and verification of the global stability of multi-storey buildings formed by flat slabs and rigid cores.

https://doi.org/10.1590/s1983-41952020000100013 1165 downloads

Desenvolvimento de biomaterial composto por hidroxiapatita e clorexidina para aplicação na cavidade oral
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Santos, M. V. B. dos

; Feitosa, G. T.

; Osajima, J. A.

; Santos, R. L. P.

; Silva Filho, E. C. da

Cerâmica

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jan 2019, Volume 65 N. 373 Pages 130 - 138

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A hidroxiapatita (HAp) está presente no organismo humano nos tecidos ósseos e dentários, em que do total da massa de cada tecido 30 a 70% correspondem a HAp, podendo ser aplicada como revestimentos de próteses ou até substituição de pequenas partes ósseas. Assim, o objetivo foi sintetizar HAp por precipitação, incorporar clorexidina (CHX) e avaliar as propriedades microbianas. A caracterização foi realizada por DRX, FTIR, TG/DTG, MET e MEV. A CHX foi incorporada à HAp por adsorção, variando a quantidade incorporada. O difratograma apresentou picos em 25,9º, 31,5°, 32,2º e 32,7º (2θ) referentes aos planos (002), (211), (112) e (300) da HAp. O espectro de FTIR mostrou banda em 1050 cm-1 correspondente à deformação dos grupos fosfatos e deformações de grupos CH2 em 1485 e 1445 cm-1 da clorexidina, que apresentou morfologia porosa e cilíndrica. O biomaterial apresentou excelentes propriedades antimicrobianas frente a Streptococcus mutans, Staphylococcus aureus e Escherichia coli.

Abstract Hydroxyapatite (HAp) is present in the human body in bone and dental tissues, which of the total mass of each tissue 30 to 70% correspond to HAp, and can be applied as coatings of prostheses or replacement of small bone parts. Thus, the objective was to synthesize HAp by precipitation, to incorporate chlorhexidine (CHX) and to evaluate the microbial properties. The characterization was performed by XRD, FTIR, TG/DTG, TEM and SEM. CHX was incorporated into the HAp by adsorption, varying the amount incorporated. The XRD pattern showed peaks at 25.9º, 31.5º, 32.2ºand 32.7º (2θ) for planes (002), (211), (112) and (300) of HAp. The FTIR spectrum showed band at 1050 cm-1 corresponding to the deformation of the phosphate groups and deformations of CH2 groups at 1485 and 1445 cm-1 of chlorhexidine, which presented porous and cylindrical morphology. The biomaterial showed excellent antimicrobial properties against Streptococcus mutans, Staphylococcus aureus and Escherichia coli.

https://doi.org/10.1590/0366-69132019653732441 1398 downloads

10.

Human Heat stress risk prediction in the Brazilian semiarid Region based on the Wet-Bulb Globe Temperature
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OLIVEIRA, BEATRIZ FÁTIMA A. DE

; SILVEIRA, ISMAEL HENRIQUE

; FEITOSA, RENATO C.

; HORTA, MARCO AURÉLIO P.

; JUNGER, WASHINGTON L.

; HACON, SANDRA

Anais da Academia Brasileira de Ciências

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2019, Volume 91 N. 3 elocation e20180748

Abstract: En | Text: En | PDF: En

Abstract: Objective: the aim of this study is to map thermal stress risks for human health at the São Francisco River Basin (SFRB) in the Semiarid region, for climatic scenarios RCP 4.5 and 8.5. Methods: The heat stress conditions were defined by the Wet Bulb Globe Temperature (WBGT) indicator and by the average number of annual days in which the WBGT values exceeded the 90th percentile of the reference period. The WBGT was estimated for the climate scenarios RCP 4.5 (intermediate) and 8.5 (pessimistic) for the period 2011-2090 comparing to the period of reference (1961-2005). Results: The projections show that for the pessimistic scenario practically all municipalities of the SFRB region can reach values of WBGT that indicate a high risk for heat stress in the period 2071-2099. For this same scenario and period, the municipalities of the Lower and Under-average regions may present values of WBGT above the 90th percentile of the reference period in more than 90% of the days/year. Conclusions: These results show that, if the emission of greenhouse gases continues in the present proportions, some municipalities of the SFRB region may present a high risk for heat stress affecting the work capacity and the practice of physical exercises.

https://doi.org/10.1590/0001-3765201920180748 1366 downloads

11.

Attractive activity of plant extracts for the oviposition of Aedes aegypti L. (Diptera: Culicidae)
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Leite Alves, Antônio Carlos

; Iarley da Silva, Toshik

; Roberto de Azevedo, Francisco

; Rocha Virgulino, Renata

; Trummer Leandro Costa, Clarice Estácio

; Valmir Feitosa, José

; Pereira Lima, Estelita

; Azevedo, Raul

Idesia (Arica)

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jul 2018, Volume 36 N. 2 Pages 225 - 231

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Aedes aegypti is one of the most important culicidae species for public health, since it transmits the viruses for yellow fever, dengue fever, chikungunya and zika. With the purpose of analyzing the effect of plant extracts on the oviposition of this vector in ovitraps, 100 ovitraps were set containing an attractive plant substrate and a pressed wooden palette vertically installed on the pot for female oviposition. The traps were randomly distributed in 10 neighborhoods of Crato, Ceará, Brazil. To determine the best extract, water from the supply network, distilled water, sewage and aqueous extracts of plant leaves from guava (Psidium guajava L.), papaya (Carica papaya L), cassava (Manihot esculenta Grantz), cashew tree (Anacardium occidentale L.), sorghum (Sorghum bicolor L., Moench) and grass hay (Cynodon nlemfluensis Vanderyst) were used. The substrates were prepared at the Laboratory of Agricultural Entomology at the Center of Agricultural Sciences and Biodiversity of the Federal University of Cariri (UFCA). Leaves were collected from the plants and crushed using a blender and then mixed with water at a concentration of 50 g of each substrate per liter of water. The material was stored for seven days in a dark room to facilitate the reactions and avoid the photoinactivation of active compounds. To determinate the best concentration, guava leaves were used subject to the same treatment of the first experiment, at concentrations of 0.5, 1; 5, 10, 25, 50, and 75 g of substrate per liter of water. Traps with sewage water showed the highest attractiveness for the oviposition of A. aegypti and the extract of guava leaves showed the highest percentage of egg attractiveness for the vector mosquito. These results can be useful to guide the adoption of new entomological surveillance and control methods of A. aegypti.

RESUMEN Aedes aegypti es una de las especies de culícidos más importantes para la salud pública, pues es transmisor de los virus de la fiebre amarilla, dengue, chikungunya y zika. Intentando analizar el efecto de extractos vegetales sobre la ovoposición de ese vector en trampas de ovoposición, fueron instaladas 100 trampas conteniendo en su interior sustrato atrayente de un vegetal y una paleta de madera prensada insertada en la posición vertical de la pared del vaso para que la hembra realice la postura. Las trampas fueron distribuidas, al azar, en 10 barrios de Crato-CE. Para determinar el mejor extracto fueron utilizadas agua de la red de suministro, agua destilada, desagüe y extractos acuosos de las hojas del guayabo (Psidium guajava L.), papayo (Carica papaya L.), mandioca (Manihot esculenta Crantz), anacardo (Anacardium occidentale L.), sorgo (Sorghum bicolor L., Moench) y heno de la gramínea (Cynodon nlemfluemsis Vanderyst). Los sustratos fueron preparados en el Laboratorio de Entomología Agrícola, en el Centro de Ciencias Agrarias y de Biodiversidad (CCAB), de la Universidad Federal de Cariri (UFCA). Las hojas fueron extraídas de la planta y enseguida, trituradas en una licuadora y mezcladas con agua en concentración de 50 g de cada sustrato por litro de agua. El material pasó siete días en ambiente oscuro para facilitar las reacciones y evitar la foto inactivación de los ingredientes activos. Para determinar la mejor concentración fueron utilizadas hojas del guayabo sometidas a las mismas etapas del primer experimento, aplicadas en las concentraciones de 0,5; 1; 5; 10; 25; 50 y 75 g del sustrato por litro de agua. Trampas cebadas con agua de desagüe manifiestan mayor atractividad para la ovoposición del A. aegypti y el extracto de la hoja del guayabo presenta mayor porcentaje de atractividad de huevos del mosquito vector. Estos resultados pueden ser útiles para orientar la adopción de métodos de vigilancia entomológica con ovotrampas y control del A. aegypti.

560 downloads

12.

Screening for common mental disorders using the SRQ-20 in Brazil: what are the alternative strategies for analysis?
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Barreto do Carmo, Maria B.

; Santos, Leticia M. dos

; Feitosa, Caroline A.

; Fiaccone, Rosemeire L.

; Silva, Nívea B. da

; Santos, Darci N. dos

; Barreto, Maurício L.

; Amorim, Leila D.

Brazilian Journal of Psychiatry

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jun 2018, Volume 40 N. 2 Pages 115 - 122

Abstract: En | Text: En | PDF: En

Objective: To analyze the prevalence of common mental disorders (CMD) assessed with the Self Reporting Questionnaire (SRQ-20), using the established cutoff point, and comparing it with the results of a joint correspondence factor analysis (CFA) and cluster analysis and of a latent class analysis (LCA). Methods: A cross-sectional study was carried out in an urban sample of 1,095 women aged 19 to 55 years. Joint CFA-cluster analysis and LCA were used. Results: We found a high prevalence of CMD, regardless of classification method (37.6% when using the cutoff point; 44.4% and 52% for LCA and joint CFA-cluster, respectively). The alternative analysis strategies describe the cases more efficiently when compared to the traditional cutoff method, especially regarding more severe symptoms. Both alternative strategies also provide a description of the SRQ-20 dimensions in their particularities, which may be useful for the planning and implementation of specific actions in a given population. Conclusion: The SRQ-20 cutoff point seems to underestimate the magnitude of CMD among women. The alternative methods of analysis presented herein highlight the different possibilities of using this important instrument of screening for mental health.

https://doi.org/10.1590/1516-4446-2016-2139 3910 downloads

13.

Recommendations of the Brazilian Society of Rheumatology for the diagnosis and treatment of chikungunya fever. Part 2 - Treatment
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Marques, Claudia Diniz Lopes

; Duarte, Angela Luzia Branco Pinto

; Ranzolin, Aline

; Dantas, Andrea Tavares

; Cavalcanti, Nara Gualberto

; Gonçalves, Rafaela Silva Guimarães

; Rocha Junior, Laurindo Ferreira da

; Valadares, Lilian David de Azevedo

; Melo, Ana Karla Guedes de

; Freire, Eutilia Andrade Medeiros

; Teixeira, Roberto

; Neto, Francisco Alves Bezerra

; Medeiros, Marta Maria das Chagas

; Carvalho, Jozélio Freire de

; Santos, Mario Sergio F.

; Océa, Regina Adalva de L. Couto

; Levy, Roger A.

; Andrade, Carlos Augusto Ferreira de

; Pinheiro, Geraldo da Rocha Castelar

; Abreu, Mirhelen Mendes

; Verztman, José Fernando

; Merenlender, Selma

; Ribeiro, Sandra Lucia Euzebio

; Costa, Izaias Pereira da

; Pileggi, Gecilmara

; Trevisani, Virginia Fernandes Moça

; Lopes, Max Igor Banks

; Brito, Carlos

; Figueiredo, Eduardo

; Queiroga, Fabio

; Feitosa, Tiago

; Tenório, Angélica da Silva

; Siqueira, Gisela Rocha de

; Paiva, Renata

; Vasconcelos, José Tupinambá Sousa

; Christopoulos, Georges

Revista Brasileira de Reumatologia

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2017, Volume 57 Suppl. 2 Pages s438 - s451

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A febre chikungunya tem se tornado um importante problema de saúde pública nos países onde ocorrem as epidemias, visto que metade dos casos evolui com artrite crônica, persistente e incapacitante. Os dados na literatura sobre terapêuticas específicas nas diversas fases da artropatia ocasionada pela infecção pelo vírus chikungunya (CHIKV) são limitados, não existem estudos randomizados de qualidade que avaliem a eficácia das diferentes terapias. Há algumas poucas publicações sobre o tratamento das manifestações musculoesqueléticas da febre chikungunya, porém com importantes limitações metodológicas. Os dados atualmente disponíveis não permitem conclusões favoráveis ou contrárias a terapêuticas específicas, bem como uma adequada avaliação quanto à superioridade entre as diferentes medicações empregadas. O objetivo deste trabalho foi elaborar recomendações para o tratamento da febre chikungunya no Brasil. Foi feita uma revisão da literatura com seleção de artigos baseados em evidência, nas bases de dados Medline, SciELO, PubMed e Embase e de resumos de anais de congressos, além da opinião dos especialistas para dar apoio às decisões tomadas para definir as recomendações. Para a definição do grau de concordância foi feita uma metodologia Delphi, em duas reuniões presenciais e várias rodadas de votação on line. Este artigo refere-se à parte 2 das Recomendações da Sociedade Brasileira de Reumatologia para Diagnóstico e Tratamento da Febre Chikungunya, que trata especificamente do tratamento.

Abstract Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations. The data currently available preclude conclusions favorable or contrary to specific therapies, or an adequate comparison between the different drugs used. The objective of this study was to develop recommendations for the treatment of chikungunya fever in Brazil. A literature review was performed via evidence-based selection of articles in the databases Medline, SciELO, PubMed and Embase and conference proceedings abstracts, in addition to expert opinions to support decision-making in defining recommendations. The Delphi method was used to define the degrees of agreement in 2 face-to-face meetings and several online voting rounds. This study is part 2 of the Recommendations of the Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia - SBR) for the Diagnosis and Treatment of chikungunya fever and specifically addresses treatment.

https://doi.org/10.1016/j.rbre.2017.06.004 38509 downloads

14.

Recommendations of the Brazilian Society of Rheumatology for diagnosis and treatment of Chikungunya fever. Part 1 - Diagnosis and special situations
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Marques, Claudia Diniz Lopes

; Duarte, Angela Luzia Branco Pinto

; Ranzolin, Aline

; Dantas, Andrea Tavares

; Cavalcanti, Nara Gualberto

; Gonçalves, Rafaela Silva Guimarães

; Rocha Junior, Laurindo Ferreira da

; Valadares, Lilian David de Azevedo

; Melo, Ana Karla Guedes de

; Freire, Eutilia Andrade Medeiros

; Teixeira, Roberto

; Bezerra Neto, Francisco Alves

; Medeiros, Marta Maria das Chagas

; Carvalho, Jozélio Freire de

; Santos, Mario Sergio F.

; Océa, Regina Adalva de L. Couto

; Levy, Roger A.

; Andrade, Carlos Augusto Ferreira de

; Pinheiro, Geraldo da Rocha Castelar

; Abreu, Mirhelen Mendes

; Verztman, José Fernando

; Merenlender, Selma

; Ribeiro, Sandra Lucia Euzebio

; Costa, Izaias Pereira da

; Pileggi, Gecilmara

; Trevisani, Virginia Fernandes Moça

; Lopes, Max Igor Banks

; Brito, Carlos

; Figueiredo, Eduardo

; Queiroga, Fabio

; Feitosa, Tiago

; Tenório, Angélica da Silva

; Siqueira, Gisela Rocha de

; Paiva, Renata

; Vasconcelos, José Tupinambá Sousa

; Christopoulos, Georges

Revista Brasileira de Reumatologia

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2017, Volume 57 Suppl. 2 Pages s421 - s437

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A febre chikungunya tem se tornado um importante problema de saúde pública nos países onde ocorrem as epidemias. Até 2013, as Américas haviam registrado apenas casos importados quando, em outubro desse mesmo ano, foram notificados os primeiros casos na Ilha de Saint Martin, no Caribe. No Brasil, os primeiros relatos autóctones foram confirmados em setembro de 2014 e até a semana epidemiológica 37 de 2016 já haviam sido registrados 236.287 casos prováveis de infecção pelo chikungunya vírus (CHIKV), 116.523 confirmados sorologicamente. As mudanças ambientais causadas pelo homem, o crescimento urbano desordenado e o número cada vez maior de viagens internacionais têm sido apontados como os fatores responsáveis pela reemergência de epidemias em grande escala. Caracterizada clinicamente por febre e dor articular na fase aguda, em cerca de metade dos casos existe evolução para a fase crônica (além de três meses), com dor persistente e incapacitante. O objetivo deste trabalho foi elaborar recomendações para diagnóstico e tratamento da febre chikungunya no Brasil. Para isso, foi feita revisão da literatura nas bases de dados Medline, SciELO e PubMed, para dar apoio às decisões tomadas para definir as recomendações. Para a definição do grau de concordância foi feita uma metodologia Delphi, em duas reuniões presenciais e várias rodadas de votação on line. Foram geradas 25 recomendações, divididas em três grupos temáticos: (1) diagnóstico clínico, laboratorial e por imagem; (2) situações especiais e (3) tratamento. Na primeira parte estão os dois primeiros temas e o tratamento na segunda.

Abstract Chikungunya fever has become a relevant public health problem in countries where epidemics occur. Until 2013, only imported cases occurred in the Americas, but in October of that year, the first cases were reported in Saint Marin island in the Caribbean. The first autochthonous cases were confirmed in Brazil in September 2014; until epidemiological week 37 of 2016, 236,287 probable cases of infection with Chikungunya virus had been registered, 116,523 of which had serological confirmation. Environmental changes caused by humans, disorderly urban growth and an ever-increasing number of international travelers were described as the factors responsible for the emergence of large-scale epidemics. Clinically characterized by fever and joint pain in the acute stage, approximately half of patients progress to the chronic stage (beyond 3 months), which is accompanied by persistent and disabling pain. The aim of the present study was to formulate recommendations for the diagnosis and treatment of Chikungunya fever in Brazil. A literature review was performed in the MEDLINE, SciELO and PubMed databases to ground the decisions for recommendations. The degree of concordance among experts was established through the Delphi method, involving 2 in-person meetings and several online voting rounds. In total, 25 recommendations were formulated and divided into 3 thematic groups: (1) clinical, laboratory and imaging diagnosis; (2) special situations; and (3) treatment. The first 2 themes are presented in part 1, and treatment is presented in part 2.

https://doi.org/10.1016/j.rbre.2017.05.006 37996 downloads

15.

Annularins I and J: New Metabolites Isolated from Endophytic Fungus Exserohilum rostratum
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Pinheiro, Eduardo A. A.

; Borges, Fabio C.

; Pina, Jeferson R. S.

; Ferreira, Leila R. S.

; Cordeiro, Jorgeffson S.

; Carvalho, Josiwander M.

; Feitosa, André O.

; Campos, Francinete R.

; Barison, Andersson

; Souza, Afonso D. L.

; Marinho, Patrícia S. B.

; Marinho, Andrey M. R.

Journal of the Brazilian Chemical Society

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aug 2016, Volume 27 N. 8 Pages 1432 - 1436

Abstract: En | Text: En | PDF: En

The paper describes the isolation of ergosterol peroxide, monocerin, annularin I and annularin J compounds of Exserohilum rostratum biomass extracts. Compounds were isolated by silica gel column chromatography in polarity gradient and the structures were determined by nuclear magnetic resonance (NMR) and mass spectrometry (MS) methods. Monocerin, annularin I and annularin J compounds were tested against Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis bacteria and showed moderate activity. Annularin I and annularin J compounds are new natural products.

https://doi.org/10.5935/0103-5053.20160140 931 downloads

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