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Risk Factors for Symptomatic Cyclops Lesion Formation after Anterior Cruciate Ligament Reconstruction
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Helito, Camilo Partezani

; Silva, Andre Giardino Moreira da

; Giglio, Pedro Nogueira

; Pádua, Vitor Barion Castro de

; Pécora, José Ricardo

; Gobbi, Riccardo Gomes

Revista Brasileira de Ortopedia

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sep 2023, Volume 58 N. 5 Pages 760 - 765

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective To evaluate the incidence of symptomatic cyclops lesions requiring surgical treatment after anterior cruciate ligament (ACL) reconstruction and to establish possible intraoperative risk factors related to it. Methods Three hundred and eighty-nine patients aged between 18 and 50 years who underwent primary ACL reconstruction were retrospectively evaluated. Patients were divided into groups according to the presence or absence of symptomatic cyclops lesions, and their characteristics were compared. Patients with associated lesions that required additional surgical procedures (except anterolateral extra-articular procedures) were not included. The rate of symptomatic cyclops lesions was recorded and the following parameters were evaluated: age, gender, time from injury to surgery, graft type and diameter, femoral tunnel perforation technique, fixation type, presence of knee hyperextension, preservation of the ACL remnant, associated anterolateral extra-articular procedure, associated meniscal injury and participation in sports. Results 389 patients were evaluated and 26 (6.7%) patients developed cyclops. The patients with and without cyclops lesions did not differ in age, time from injury to surgery, graft type or diameter, surgical technique, femoral fixation method, presence of knee hyperextension, remnant preservation and associated meniscal injury. The group with cyclops lesion had a higher proportion of females (10 (38.4%) vs 68 (18.7%); OR = 2.7; p= 0.015), higher proportion of extra-articular reconstruction (18 (11.8%) vs 8 (3.4%); OR = 3.8; p= 0.001) and higher proportion of sports practice (23 (8.6%) vs 3 (2.5%); OR = 3.6; p= 0.026). Conclusion In our series, 6.7% of the patients required arthroscopic removal of cyclops lesions. Female gender, associated extra-articular reconstruction and sports practice were factors related to this lesion. Remnant preservation had no relationship with cyclops lesion formation.

Resumo Objetivo Avaliar a incidência de lesões cyclops sintomáticas que precisam de tratamento cirúrgico após a reconstrução do ligamento cruzado anterior (LCA) e estabelecer os possíveis fatores de risco intraoperatórios relacionados a elas. Métodos Trezentos e oitenta e nove pacientes com idades entre 18 e 50 anos submetidos à reconstrução primária do LCA foram avaliados de forma retrospectiva. Os pacientes foram divididos em grupos de acordo com a presença ou ausência de lesões cyclops sintomáticas e suas características foram comparadas. Não foram incluídos pacientes com lesões associadas que necessitassem de outros procedimentos cirúrgicos (à exceção de procedimentos extra-articulares ântero-laterais). A taxa de lesões cyclops sintomáticas foi registrada e os seguintes parâmetros foram avaliados: idade, sexo, tempo da lesão à cirurgia, tipo e diâmetro do enxerto, técnica de perfuração do túnel femoral, tipo de fixação, presença de hiperextensão do joelho, preservação do LCA remanescente, associação a procedimento extra-articular ântero-lateral, lesão de menisco associada e participação em esportes. Resultados Dos 389 pacientes avaliados, 26 (6,7%) desenvolveram lesão cyclops. Os pacientes com e sem lesão cyclops não diferiram quanto à idade, tempo da lesão à cirurgia, tipo ou diâmetro do enxerto, técnica cirúrgica, método de fixação femoral, presença de hiperextensão do joelho, preservação do LCA remanescente e lesão de menisco associada. O grupo com lesão cyclops apresentou mais mulheres (10 [38,4%] vs. 68 [18,7%]; razão de probabilidades [OR] = 2,7; p= 0,015), maior proporção de reconstrução extra-articular (18 [11,8%] vs. 8 [3,4 %]; OR = 3,8; p= 0,001) e maior proporção de prática esportiva (23 [8,6%] vs. 3 [2,5%]; OR = 3,6; p= 0,026). Conclusão Em nossa série, 6,7% dos pacientes necessitaram de remoção artroscópica das lesões cyclops. O sexo feminino, a reconstrução extra-articular associada e a prática esportiva foram fatores relacionados a essa lesão. A preservação do menisco remanescente não foi associada à formação de lesões cyclops.

https://doi.org/10.1055/s-0043-1776138

Prevalence and interference of neuropathic pain in the quality of life in patients with knee osteoarthritis
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Helito, Camilo Partezani

; Moreira, Fernando Sant’Anna

; Santiago, Matheus Augusto Maciel

; Medeiros, Lucas de Faria Barros

; Giglio, Pedro Nogueira

; Silva, Andre Giardino Moreira da

; Gobbi, Riccardo Gomes

; Pecora, Jose Ricardo

Clinics

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2023, Volume 78 elocation 100287

Abstract: En | Text: En | PDF: En

Abstract Objective: With the aging of the population, more patients have complained of pain due to knee Osteoarthritis (OA), and the number of arthroplasties has also increased. The objective of this study is to evaluate the prevalence of the neuropathic pain component in candidates for Total Knee Replacement and the effects of this component on their quality of life. Methods: In this cross-sectional study, patients with OA candidates for knee arthroplasty in the present institution were evaluated using the pain detection questionnaire and the Visual Analog Pain (VAS) scale to measure the pain index and the presence of associated neuropathic pain. In addition, evaluation of the quality of life and functionality using the EQ5D and SF12 questionnaires and their relationship with cases of neuropathic pain were performed. Results: One hundred twenty-six patients were evaluated, and 71.4 % were female. The age ranged from 46 to 85 years, and about 70 % of the patients had some associated clinical comorbidity. Neuropathic pain was present in 28.6 % of the patients evaluated. Patients with neuropathic pain presented worse results in the VAS evaluation, in the care, pain, and anxiety domains of the EQ5D, and in the physical and mental scores of the SF12. Conclusion: Neuropathic pain was present in 28.6 % of the patients with knee OA who are candidates for arthro-plasty. Patients with associated neuropathic pain present a higher level of pain and worse quality of life scores. Recognizing this type of pathology is extremely important in fully monitoring gonarthrosis.

https://doi.org/10.1016/j.clinsp.2023.100287

A late diagnosis of hyperhomocysteinemia with probable evolution to verrucous elephantiasis nostra and leg ulcers,
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Abdalla, Beatrice Martinez Zugaib

; de Oliveira, Renan Tironi Giglio

; Afonso, Rafaela Issa

; Criado, Paulo Ricardo

Anais Brasileiros de Dermatologia

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mar 2021, Volume 96 N. 2 Pages 253 - 255

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2020.04.014 79 downloads

Socioeconomic impact of high-cost drugs in Brazilian dermatology. Legal and financial aspects, and impact on clinical practice
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de Oliveira, Renan Tironi Giglio

; Agostinho, Giovana Larissa Prado Leite

; Granja, Rubens

; Oyafuso, Luiza Keiko M.

; Criado, Paulo Ricardo

Anais Brasileiros de Dermatologia

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mar 2021, Volume 96 N. 2 Pages 200 - 209

Abstract: En | Text: En | PDF: En

Abstract The technological advancement of the pharmaceutical industry, resulting from the techniques of molecular biology and expansion of the knowledge of immunopathogenesis, has modified the therapeutic arsenal used in dermatology. Scientific research and regulatory standards cause drug costs to rise, thus making their use impossible in most public policies. In order to make high-cost drugs viable in the public health network, the Specialized Pharmaceutical Assistance Component was created. However, despite the frequent incorporation of medications, the constant requirement of drugs through lawsuits leads to exorbitant costs to the state budget. The present work analyzed through a descriptive observational study, the current situation of the Specialized Component and the involvement of medicines used in dermatology, through legal reviews, financial analyses, and medical articles, aiming at future incorporations for the specialty. When assessing the legal demands for dermatological drugs in the state of São Paulo, the specialty still has a low participation and psoriasis is the main disease involved in requiring drugs through the judicial system in the state. New methods of access to raw materials must be created to reduce legal issues. Cost-effectiveness and public planning studies are mandatory for incorporating new dermatological therapies.

https://doi.org/10.1016/j.abd.2020.08.010 152 downloads

Registro Multicêntrico de Takotsubo (REMUTA) – Aspectos Clínicos, Desfechos Intra-Hospitalares e Mortalidade a Longo Prazo
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Almeida Junior, Gustavo Luiz Gouvêa de

; Mansur Filho, João

; Albuquerque, Denilson Campos de

; Xavier, Sergio Salles

; Pontes, Álvaro

; Gouvêa, Elias Pimentel

; Martins, Alexandre Bahia Barreiras

; Nunes, Nágela S. V.

; Carestiato, Lilian Vieira

; Petriz, João Luiz Fernandes

; Santos, Armando Márcio Gonçalves

; Bandeira, Bruno Santana

; Abufaiad, Bárbara Elaine de Jesus

; Pacheco, Luciana da Camara

; Oliveira, Maurício Sales de

; Ribeiro Filho, Paulo Eduardo Campana

; Sampaio, Pedro Paulo Nogueres

; Duque, Gustavo Salgado

; Camillis, Luiz Felipe

; Marques, André Casarsa

; Lourenço Jr, Francisco Carlos

; Palazzo, José Ricardo

; Costa, Cláudio Ramos da

; Silva, Bibiana Almeida da

; Zukowski, Cleverson Neves

; Garcia, Romulo Ribeiro

; Zonis, Fernanda de Carvalho

; Paula, Suzana Andressa Morais de

; Ferrari, Carolina Gravano Ferraz

; Rangel, Bruno Soares da Silva

; Ferreira, Roberto Muniz

; Mendes, Bárbara Ferreira da Silva

; Castro, Isabela Ribeiro Carvalho de

; Souza, Leonardo Giglio Gonçalves de

; Araújo, Luiz Henrique dos Santos

; Giani, Alexandre

Arquivos Brasileiros de Cardiologia

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aug 2020, Volume 115 N. 2 Pages 207 - 216

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A síndrome de takotsubo (takotsubo) é uma forma de cardiomiopatia adquirida. Dados nacionais sobre essa condição são escassos. O Registro REMUTA é o primeiro a incluir dados multicêntricos dessa condição no nosso país. Objetivo Descrever as características clínicas, prognóstico, tratamento intra-hospitalar e mortalidade hospitalar e em 1 ano de seguimento. Métodos Estudo observacional, retrospectivo, tipo registro. Incluídos pacientes internados com diagnóstico de takotsubo ou que desenvolveram esta condição durante internação por outra causa. Os desfechos avaliados incluíram fator desencadeador, análise dos exames, uso de medicações, complicações e óbito intra-hospitalar e em 1 ano de seguimento. O nível de significância adotado foi de 5%. Resultados Foram incluídos 169 pacientes, em 12 centros no Estado do Rio de Janeiro. A idade média foi de 70,9 ± 14,1 anos e 90,5% eram do sexo feminino; 63% dos casos foram de takotsubo primário e 37% secundário. Troponina I foi positiva em 92,5% dos pacientes e a mediana de BNP foi de 395 (176,5; 1725). Supradesnivelamento do segmento ST esteve presente em 28% dos pacientes. A fração de ejeção do ventrículo esquerdo teve mediana de 40 (35; 48)%. Observamos taxa de 25,7% de ventilação mecânica invasiva e 17,4% de choque. Suporte circulatório mecânico foi utilizado em 7,7%. A mortalidade intra-hospitalar foi de 10,6% e a mortalidade ao final de 1 ano foi de 16,5%. Takotsubo secundário e choque cardiogênico foram preditores independentes de mortalidade. Conclusão Os resultados do REMUTA mostram que takotsubo não se trata de patologia benigna como se pensava, especialmente no grupo de takotsubo secundário que acarreta elevada taxa de complicações e de mortalidade. (Arq Bras Cardiol. 2020; 115(2):207-216)

Abstract Background Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil. Objective To describe the clinical characteristics, prognosis, in-hospital treatment, in-hospital mortality, and mortality during 1 year of follow-up. Methods This is an observational, retrospective registry study including patients admitted to the hospital with diagnosis of TTS and patients admitted for other reasons who developed this condition. Evaluated outcomes included triggering factor, analysis of exams, use of medications, complications, in-hospital mortality, and mortality during 1 year of follow-up. A significance level of 5% was adopted. Results The registry included 169 patients from 12 centers in the state of Rio de Janeiro, Brazil. Mean age was 70.9 ± 14.1 years, and 90.5% of patients were female; 63% of cases were primary TTS, and 37% were secondary. Troponin I was positive in 92.5% of patients, and median BNP was 395 (176.5; 1725). ST-segment elevation was present in 28% of patients. Median left ventricular ejection fraction was 40 (35; 48)%. We observed invasive mechanical ventilation in 25.7% of cases and shock in 17.4%. Mechanical circulatory support was used in 7.7%. In-hospital mortality was 10.6%, and mortality at 1 year of follow-up was 16.5%. Secondary TTS and cardiogenic shock were independent predictors of mortality. Conclusion The results of the REMUTA show that TTS is not a benign pathology, as was once thought, especially regarding the secondary TTS group, which has a high rate of complications and mortality. (Arq Bras Cardiol. 2020; 115(2):207-216)

https://doi.org/10.36660/abc.20190166 1217 downloads

AUTOLOGOUS CHONDROCYTE IMPLANTATION IN BRAZIL
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GIGLIO, PEDRO NOGUEIRA

; LIZIER, NELSON FORESTO

; LEVY, DÉBORA

; SOBRADO, MARCEL FARACO

; GOBBI, RICCARDO GOMES

; PÉCORA, JOSÉ RICARDO

; BYDLOWSKI, SERGIO PAULO

; DEMANGE, MARCO KAWAMURA

Acta Ortopédica Brasileira

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jun 2020, Volume 28 N. 3 Pages 131 - 136

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever a primeira série de casos de transplante autólogo de condrócitos (TAC) em membrana de colágeno realizada no Brasil. Métodos: Doze joelhos de onze pacientes, com idade de 32,1 ± 10,9 anos, com lesões de cartilagem de espessura total do joelho de tamanho de 5,3 ± 2,6 cm 2 foram submetidos ao TAC, com seguimento mínimo de seis meses. Realizamos dois procedimentos cirúrgicos: biópsia artroscópica de cartilagem para isolamento e expansão de condrócitos, que foram semeados em uma membrana de colágeno implantada no leito da lesão. Foi realizada caracterização com imunofluorescência para colágeno tipo II (COL2) de células cultivadas e implantes, viabilidade celular e microscopia eletrônica no implante. Foram avaliados a segurança clínica, os escores funcionais KOOS e IKDC e a ressonância magnética. Utilizamos teste ANOVA para medidas repetidas, com comparações post-hoc, α = 5%. Resultados: COL2 foi identificado no citoplasma da célula, viabilidade celular foi superior a 95% e houve distribuição adequada e adesão celular na membrana. O seguimento mediano foi de 10,9 meses (7 a 19). Como complicações, ocorreram dois casos de artrofibrose, um de hipertrofia do enxerto e um de infecção superficial, nenhum deles havendo comprometimento da melhora clínica. Escalas KOOS e IKDC passaram de 71,2 ± 11,44 e 50,72 ± 14,10, no pré-operatório, para 85,0 ± 4,4 e 70,5 ± 8,0, aos 6 meses (p = 0,007 e 0,005). Ressonância magnética mostrou tecido regenerado compatível com cartilagem hialina. Conclusão: TAC em membrana de colágeno foi viável e seguro em seguimento de curto prazo, apresentando formação de regenerado visualizado através de imagens de ressonância magnética e melhora de função clínica. Nível de evidência IV, Série de casos.

ABSTRACT Objective: To describe the first series of cases of autologous chondrocyte implantation (ACI) in collagen membrane performed in Brazil. Methods: ACI was performed in 12 knees of 11 patients, aged 32.1 ± 10.9 years, with 5.3 ± 2.6 cm2 full-thickness knee cartilage lesions, with a six-month minimum follow-up. Two surgical procedures were performed: arthroscopic cartilage biopsy for isolation and expansion of chondrocytes, which were seeded onto collagen membrane and implanted in the lesion site; the characterization of cultured cells and implant was performed using immunofluorescence for type II collagen (COL2) for cell viability and electron microscopy of the implant. Clinical safety, KOOS and IKDC scores and magnetic resonance imaging were evaluated. We used repeated-measures ANOVA and post-hoc comparisons at α = 5%. Results: COL2 was identified in the cellular cytoplasm, cell viability was higher than 95% and adequate distribution and cell adhesion were found in the membrane. The median follow-up was 10.9 months (7 to 19). We had two cases of arthrofibrosis, one of graft hypertrophy and one of superficial infection as complications, but none compromising clinical improvement. KOOS and IKDC ranged from 71.2 ± 11.44 and 50.72 ± 14.10, in preoperative period, to 85.0 ± 4.4 and 70.5 ± 8.0, at 6 months (p = 0.007 and 0.005). MRI showed regenerated tissue compatible with hyaline cartilage. Conclusion: ACI in collagen membrane was feasible and safe in a short-term follow-up, presenting regenerated formation visualized by magnetic resonance imaging and improved clinical function. Level of evidence IV, Case series.

https://doi.org/10.1590/1413-785220202803226503 854 downloads

Comparison of Floseal® and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study
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Helito, Camilo Partezani

; Bonadio, Marcelo Batista

; Sobrado, Marcel Faraco

; Giglio, Pedro Nogueira

; Pécora, José Ricardo

; Camanho, Gilberto Luis

; Demange, Marco Kawamura

Clinics

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2019, Volume 74 elocation e1186

Abstract: En | Text: En | PDF: En

OBJECTIVE: Tranexamic acid (TXA) and the hemostatic agent Floseal® have already been used to minimize bleeding during total knee arthroplasty (TKA). METHODS: We conducted a prospective, randomized study of 90 patients with indications for TKA. Following inclusion, the participants were randomly allocated in blocks to the following 3 groups: control, Floseal® and TXA. Bleeding parameters, including decreases in hemoglobin (Hb), drain output, number of blood transfusions and complications, were assessed. ClinicalTrials.gov: NCT02152917. RESULTS: The mean decrease in Hb was highest in the control group (4.81±1.09 g/dL), followed by the Floseal® (3.5±1.03 g/dL) and TXA (3.03±1.2 g/dL) groups. The Floseal® and TXA groups did not differ, and both performed better than the control group. The mean total drain output was 901.3±695.7 mL in the control group, 546.5±543.5 mL in the TXA group and 331.2±278.7 mL in the Floseal® group. Both TXA and Floseal® had significantly less output than the control group, and Floseal® had significantly less output than TXA. The number of blood transfusions was very small in all 3 groups. CONCLUSION: The use of TXA or Floseal® was associated with less blood loss than that of the control group among patients undergoing primary TKA, as measured both directly (intraoperative bleeding + drainage) and on the basis of a decrease in Hb, without differences in the rate of complications. TXA and Floseal® showed similar decreases in Hb and total measured blood loss, but the drain output was smaller in the Floseal® group.

https://doi.org/10.6061/clinics/2019/e1186 1101 downloads

Subchondroplasty for treating bone marrow lesions in the knee - initial experience
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Bonadio, Marcelo Batista

; Giglio, Pedro Nogueira

; Helito, Camilo Partezani

; Pécora, José Ricardo

; Camanho, Gilberto Luis

; Demange, Marco Kawamura

Revista Brasileira de Ortopedia

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jun 2017, Volume 52 N. 3 Pages 325 - 330

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO: Avaliar o uso da técnica de subcondroplastia no tratamento das lesões medulares ósseas em série inicial de cinco casos. MÉTODOS: O estudo incluiu pacientes entre 40 e 75 anos, com dor em joelho com pelo menos seis meses de duração, associada à ressonância magnética com lesão hipercaptante em ponderação de T2 na tíbia ou no fêmur. Os pacientes foram avaliados segundo a escala visual analógica de dor (EVA) e pelo Knee Injury and Osteoarthritis Outcome Score (KOOS), uma semana antes da cirurgia e uma, três, seis, 12 e 24 semanas após. A subcondroplastia foi feita com técnica desenvolvida para o preenchimento, guiado por radioscopia, da área de lesão óssea medular, com o uso de substituto ósseo em pasta à base de fosfato de cálcio. RESULTADOS: O preenchimento foi feito com sucesso em todos os casos, quatro no côndilo femoral medial e um no planalto tibial medial. A avaliação pelo KOOS apresentou uma média pré-operatória de 38,44 pontos e 62,7, 58,08, 57,92, 63,34 e 71,26 pontos com uma, três, seis, 12 e 24 semanas após a cirurgia, respectivamente. Na avaliação pela EVA, a média foi de 7,8 pontos no pré-operatório e 2,8, 3, 2,8, 1,8 e 0,6 pontos nos mesmos períodos. Todos os pacientes conseguiram deambular, sem apoio adicional, já no primeiro dia após o procedimento. Um paciente apresentou mínimo extravasamento de enxerto para partes moles, causou dor local que se resolveu completamente após uma semana. CONCLUSÃO: A técnica de subcondroplastia desenvolvida proporcionou melhorias significativas nos parâmetros de dor e capacidade funcional na avaliação de curto prazo.

ABSTRACT OBJECTIVE: To evaluate the use of subchondroplasty in the treatment of bone marrow lesions in an initial series of five cases. METHODS: The study included patients aged between 40 and 75 years old, with pain in the knee for at least six months, associated with high-signal MRI lesion on T2 sequences, on the tibia or femur. Patients were assessed using the visual analog pain scale and the KOOS score, one week before surgery and one, three, six, 12, and 24 weeks after the procedure. Subchondroplasty was performed with a technique developed for filling the area of the bone marrow lesion with a calcium phosphate bone substitute. RESULTS: The filling was performed on the medial femoral condyle in four patients and medial tibial plateau in one case. The assessment by the KOOS score presented a preoperative average of 38.44 points and 62.7, 58.08, 57.92, 63.34, and 71.26 points with one, three, six, 12, and 24 weeks after surgery, respectively. In the evaluation by the VAS, the average was 7.8 points preoperatively and 2.8, 3, 2.8, 1.8, and 0.6 points over the same periods. All patients were able to ambulate without additional support, on the first day after the procedure. One patient had a minimal graft dislocation to the soft tissue, with local pain, which resolved completely after a week. CONCLUSION: The subchondroplasty technique provided significant improvements in the parameters of pain and functional capacity in the short-term assessment.

https://doi.org/10.1016/j.rboe.2017.04.003 3517 downloads

NEGATIVE-PRESSURE WOUND THERAPY IN THE TREATMENT OF COMPLEX INJURIES AFTER TOTAL KNEE ARTHROPLASTY
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Helito, Camilo Partezani

; Bueno, Daniel Kamura

; Giglio, Pedro Nogueira

; Bonadio, Marcelo Batista

; Pécora, José Ricardo

; Demange, Marco Kawamura

Acta Ortopédica Brasileira

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apr 2017, Volume 25 N. 2 Pages 85 - 88

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Apresentar uma experiência com a terapia com pressão negativa (TPN) no tratamento das feridas cirúrgicas de pacientes tratados por infecções em artroplastias totais do joelho (ATJ) associadas ou não à deiscência e como profilaxia nas feridas consideradas em risco de problemas de cicatrização. Métodos: Foram avaliados prospectivamente pacientes que apresentavam infecção de ATJ associada ou não à deiscência de ferida operatória e pacientes com fatores de riscos de infecção ou complicações de ferida cirúrgica tratados com dispositivo PICO(r) para TPN além do tratamento padrão da infecção ou deiscência em nossa instituição. Consideramos como desfecho favorável inicial a resolução do processo de infecção e o fechamento das deiscências de ferida operatória nos casos de tratamento e a boa evolução da ferida operatória, sem eventos complicadores, nos casos profiláticos. Resultados: Foram avaliados 10 pacientes que usaram PICO(r) em nosso serviço. Todos os pacientes apresentaram desfecho favorável de acordo com os critérios estabelecidos. Não foram identificadas quaisquer complicações com relação ao uso do dispositivo de TPN. A média de seguimento dos pacientes após o uso do dispositivo foi de 10 meses e meio. Conclusão: A TPN pode ser usada em complicações de ferida e infecção depois de ATJ de maneira segura e com resultados promissores. Estudos prospectivos randomizados prolongados devem ser realizados para comprovar sua eficácia. Nível de Evidência IV, Série de Casos.

ABSTRACT Objective: To present an experience with negative-pressure wound therapy (NPWT) in the treatment of surgical wounds in patients treated for infections after total knee arthroplasty (TKA) with or without dehiscence and prophylaxis in wounds considered at risk of healing problems. Methods: We prospectively evaluated patients with TKA infection with or without surgical wound dehiscence and patients with risk factors for infection or surgical wound complications treated with Pico(r) device for NPWT in addition to standard treatment of infection or dehiscence in our institution. We considered as an initial favorable outcome the resolution of the infectious process and the closure of the surgical wound dehiscences in the treated cases and the good progression of the wound without complicating events in the prophylactic cases. Results: We evaluated 10 patients who used Pico(r) in our service. All patients had a favorable outcome according to established criteria. No complications were identified regarding the use of the NPWT device. The mean follow-up of the patients after the use of the device was 10.5 months. Conclusion: The NPWT can be safely used in wound infections and complications following TKA with promising results. Long-term randomized prospective studies should be conducted to prove its effectiveness. Level of Evidence IV, Case Series.

https://doi.org/10.1590/1413-785220172502169053 3048 downloads

10.

Impacto de una intervención educativa para mejorar la adherencia a las recomendaciones sobre sueño seguro del lactante
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Rocca Rivarola, Manuel

; Reyes, Pablo

; Henson, Caterina

; Bosch, Juan

; Atchabahian, Pablo

; Franzosi, Ricardo

; Di Pietro, Carla

; Balboni, Constanza

; Giglio, Norberto

Archivos argentinos de pediatría

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jun 2016, Volume 114 N. 3 Pages 223 - 231

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction. In developed countries, public campaigns promoting recommendations on safe infant sleep increased adherence to the supine sleeping position to more than 70% and, at the same time, reduced the incidence of sudden infant death syndrome by 53%. Objective. To determine the impact, at 60 days of life, of an educational intervention conducted in maternity centers aimed at improving adherence to the recommendations on safe infant sleep. Population, material and methods. Intervention study with historical control conducted between February 1st and September 30th of 2014 at the Maternity Center of Hospital Meisner and Hospital Universitario Austral. The intervention was called "crib card" and consisted in training health care team members and providing families with information on safe infant sleep by means of lessons, written material and using stickers on cribs. Results. Five hundred and fifty newborn infants were included. After the intervention, a 35% increase in the supine sleeping position (p < 0.0001) was observed; exclusive breastfeeding increased by 11% (p= 0.01); and co-sleeping decreased from 31% to 18% (p < 0.0005). No differences were observed in relation to bedroom sharing, living with tobacco users, or pacifier use at 60 days of life. Conclusions. The educational intervention was useful to improve adherence to the recommendations on safe sleep at 60 days of life: using the supine position and breastfeeding improved, and the rate of co-sleeping decreased. No changes were observed in the number of household members who smoke, bedroom sharing, and pacifier use.

Introducción. Las campanas públicas en países desarrollados con recomendaciones para el sueño seguro del lactante lograron aumentar la adherencia a la posición supina para dormir a más del 70% y generaron, simultáneamente, una reducción del 53% en la incidencia del síndrome de muerte súbita del lactante. Objetivo. Valorar el impacto a los 60 días de vida de una intervención educativa realizada en las maternidades para mejorar la adherencia a las recomendaciones sobre sueño seguro del lactante. Población, material y métodos. Estudio de intervención con control histórico entre el 1/2 y el 30/9 de 2014, realizado en la Maternidad Meisner y el Hospital Universitario Austral. Dicha intervención se denominó "tapeta cuna" y consistió en capacitar al equipo de salud y brindar información a las familias sobre sueño seguro a través de clases, adhesivos en las cunas y material escrito. Resultados. Fueron incluidos 550recién nacidos. Se observó un incremento del 35% en la posición supina al dormir tras la intervención (p < 0,0001); la lactancia materna exclusiva se incrementó un 11% (p= 0,01); se redujo el colecho de un 31% a un 18% (p < 0,0005). No se encontraron diferencias en la cohabitación, entre convivientes fumadores ni en la utilización del chupete a los 60 días. Conclusiones. La intervención educativa resultó útil para mejorar la adherencia a las recomendaciones sobre sueño seguro a los 60 días de vida: se evidenció una mejora en la posición supina, la lactancia materna y la reducción del colecho. No existieron cambios en la proporción de convivientes fumadores, la cohabitación y el uso del chupete.

https://doi.org/10.5546/aap.2016.223 1051 downloads

11.

Formas de aprendizagem e graus de inovação de produto no Brasil: uma análise exploratória dos padrões setoriais de aprendizagem
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Bittencourt, Pablo Felipe

; Britto, Jorge Nogueira de Paiva

; Giglio, Ricardo

Nova Economia

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apr 2016, Volume 26 N. 1 Pages 263 - 300

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo do artigo é ampliar a compreensão da dinâmica da inovação das firmas brasileiras. Para isso, indicadores de tipos de aprendizagem e graus de inovação foram construídos, e suas relações testadas econometricamente. Dentre os resultados, além de diferenças setoriais significativas, destacamos: (i) que inovações de maior grau decorrem de formas de aprendizagem que combinam conhecimentos codificados (como os advindos das fontes avançadas de C&T) com tácitos (frutos de interação com clientes, por exemplo); (ii) que as inovações de menor grau derivam, quase que exclusivamente, da aprendizagem de conhecimentos tácitos e, que, (iii) os clientes são sempre fontes importantes aos processos de inovação. Desta última constatação, levantamos a hipótese de que a limitada dinâmica inovadora das firmas brasileiras pode ser explicada por um aprisionamento à qualidade das demandas de seus clientes. O estímulo às exportações é a principal recomendação de política derivada, por admitir-se que clientes mais sofisticados poderão induzir trajetórias tecnológicas mais promissoras.

Abstract: This paper aims to broaden the understanding of innovation dynamics in Brazilian firms. For doing so, we constructed indicators of 'types of learning' and 'degrees of innovation' and their relationships were econometrically tested. Significant sectoral differences were found. It was also found that: (i) 'higher degree' innovations arise from forms of learning that combine both codified knowledge (such as knowledge arising from advanced S&T sources) and tacit knowledge (resulting from customer interactions, for example); (ii) 'lesser degree' innovations derive almost exclusively from forms of learning that consider only tacit knowledge; and (iii) customers are always important sources for innovation processes. From the latter finding, we hypothesized that the limited dynamic innovation found in Brazilian firms can be explained by a type of 'lock-in effect' related to customers' demands for quality. The stimulus to exports is the main policy recommendation derived from this analysis, by admitting that more sophisticated customers may induce the most promising technological trajectories.

https://doi.org/10.1590/0103-6351/1979 1637 downloads

12.

Advances in treating exposed fractures
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Giglio, Pedro Nogueira

; Cristante, Alexandre Fogaça

; Pécora, José Ricardo

; Helito, Camilo Partezani

; Lima, Ana Lucia Lei Munhoz

; Silva, Jorge dos Santos

Revista Brasileira de Ortopedia

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apr 2015, Volume 50 N. 2 Pages 125 - 130

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O manejo das fraturas expostas é discutido desde a antiguidade e permanece de grande interesse da ortopedia e da traumatologia modernas. São lesões ainda desafiadoras. Infecção e não união são complicações temidas. Aspectos no diagnóstico, classificação e manejo inicial são discutidos. São essenciais a administração precoce de antibióticos, a limpeza cirúrgica e o debridamento meticuloso. Devem ser levadas em consideração as condições sistêmicas do paciente politraumatizado e as condições locais do membro acometido. A estabilização esquelética precoce é necessária. A fixação definitiva deve ser considerada quando possível e métodos de fixação provisória devem ser usados quando necessário. O fechamento precoce deve ser almejado e pode-se fazer uso de retalhos para esse fim.

The management of exposed fractures has been discussed since ancient times and remains of great interest to present-day orthopedics and traumatology. These injuries are still a challenge. Infection and nonunion are feared complications. Aspects of the diagnosis, classification and initial management are discussed here. Early administration of antibiotics, surgical cleaning and meticulous debridement are essential. The systemic conditions of patients with multiple trauma and the local conditions of the limb affected need to be taken into consideration. Early skeletal stabilization is necessary. Definitive fixation should be considered when possible and provisional fixation methods should be used when necessary. Early closure should be the aim, and flaps can be used for this purpose.

https://doi.org/10.1016/j.rboe.2015.02.009 48445 downloads

13.

Oficinas educativas como estratégia de promoção da saúde auditiva do adolescente: estudo exploratório
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Lacerda, Adriana Bender Moreira de

; Soares, Vânia Muniz Néquer

; Goncalves, Cláudia Giglio de Oliveira

; Lopes, Flávia Conceição

; Testoni, Ricardo

Audiology - Communication Research

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jun 2013, Volume 18 N. 2 Pages 85 - 92

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Desenvolver e avaliar oficinas educativas sobre saúde auditiva e exposição a ruídos de adolescentes escolares da rede pública de ensino médio. MÉTODOS: Estudo de intervenção, com a participação de 91 adolescentes. Foi realizada ação educativa, tendo como base a pedagogia problematizadora e, como recurso metodológico, o trabalho em grupo na forma de oficinas, nas quais os jovens foram convidados a refletir sobre a saúde auditiva e exposição a ruídos nas atividades culturais (lazer), escolares e ambientais. Foram utilizadas diferentes estratégias lúdicas e dialógicas, como teatro, música, roda de conversa, confecção de mural. Para avaliação das oficinas foram aplicados dois questionários: um questionário antes e outro depois das oficinas, visando identificar a mudança na compreensão dos jovens frente ao ruído, e outro sobre a dinâmica das oficinas. RESULTADOS: Após as oficinas, foram observadas mudanças na compreensão dos jovens, que passaram a considerar o ruído como algo ruim e danoso à saúde. Diferença significativa foi observada com relação aos cuidados necessários com a audição nas atividades culturais. A percepção dos alunos relacionada à dinâmica utilizada nas oficinas foi muito boa ou boa em mais de 80% das avaliações. CONCLUSÃO: As oficinas educativas demonstraram-se apropriadas para educação em saúde auditiva de escolares. Foram observadas mudanças na compreensão dos jovens, sobretudo quanto ao efeito do ruído nas atividades culturais. As estratégias lúdicas e dialógicas propostas nas oficinas foram aceitas e apreciadas pelos adolescentes.

PURPOSE: Develop and evaluate educational workshop on hearing health and noise exposure adolescents, students of public school. METHODS: Intervention study involving 91 adolescents. Educational activity was conduce based on the problem-posing education and as a methodological resource group work in the form of workshops in which young people were invited to reflect on the hearing health and noise exposure in cultural activities (leisure),and environmental education. Was used differents strategies playful and dialogical as: theater, music, conversation wheel, making mural. For evaluation of the workshop were applied two questionnaires, one questionnaire before and another after the workshop aimed at identifying and understandingc an change attitudes of young people against the noise, and the other on the development of the workshop. RESULTS: After the workshops, was observed changes in the understanding of young people, considering the noise as something bad and harmfulto health, however significant differences were observed, the necessary care with hearing related to cultural activities. The students' perceptions related to the dynamics used in the workshops was very good or goodby more than 80% of the evaluations. CONCLUSION: The educational workshops showed to be appropriate for health education of hearing students. Changes were observed in the understanding of teenagers, especially the effect of noise on cultural activities. The playful and dialogical strategies proposed in the workshop were accepted and appreciated by adolescents.

16630 downloads Cited 1 time in SciELO

14.

Epidemia de infuenza del año 2009 en un hospital pediátrico y costos médicos directos en menores de 5 años comparados con el período 2006-2008
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Giglio, Norberto D

; Castellano, Vanesa E

; Rüttimann, Ricardo W

; Vidal, Gabriela I

; Gentile, Ángela

Archivos argentinos de pediatría

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feb 2012, Volume 110 N. 1 Pages 19 - 26

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction. Epidemic outbreaks of infuenza occur every year and healthcare systems must amplify their response in accordance with available medical resources. This situation generates cost increases. During the recent infuenza A pandemic, costs were likely to have been greater than in previous years. Objective. To estimate direct health costs of infuenza-related illness during 2009 compared to costs expended in the previous 3-year period at Ricardo Gutiérrez Children's Hospital, City of Buenos Aires, Argentina. Materials and methods. We conducted a cross-sectional epidemiological study with retrospective control group to estimate infuenza-related costs for the years 2006 to 2009 using data from outpatient consultations and hospital admissions for Acute Respiratory Infections attributable to Infuenza virus in children under 5 years old. Incremental costs were estimated for the year 2009 compared to average costs for the period 2006-2008. Results. Total incremental cost of hospital admissions and outpatient consultations for infuenza was US$ 91512 for the year 2009 compared to average cost for 2006-2008 period (incremental cost of US$ 147560 for hospital admissions and US$ -56048 for outpatient consultations). Conclusions. Infuenza-related costs were greater in 2009 than in previous years due to higher number of hospital admissions attributable to infuenza A H1N1.

Introducción. Anualmente se producen brotes epidémicos de variada intensidad atribuibles a Infuenza y las instituciones de salud multiplican su capacidad de respuesta en términos de recursos médicos. Este cuadro genera un incremento en los costos institucionales durante la circulación del virus y, con la aparición del nuevo virus pandémico Infuenza A (pH1N1), los costos podrían haber aumentado en relación a los años anteriores. Objetivo. Valorar los costos directos en salud atribuibles a infuenza durante el año 2009 y compararlo con años previos en el Hospital de Niños Ricardo Gutiérrez (HNRG) de la Ciudad de Buenos Aires, Argentina. Material y métodos. Con datos de las consultas ambulatorias e internaciones por Infección Respiratoria Aguda atribuibles a Infuenza de los años 2006 a 2009 se realizó un estudio epidemiológico de corte transversal, con control retrospectivo, para valorar costos en niños menores de 5 años. Con los costos obtenidos para cada año, se realizó el cálculo del costo incremental del período de estudio 2009 en relación al costo promedio de los períodos 2006-2008. Resultados. El costo incremental total (hospitalizaciones y consultas ambulatorias por infuenza) del período de estudio 2009 en relación al costo promedio del período 2006-2007-2008 fue US$ 91 512. Para las hospitalizaciones, el costo incremental del período de estudio 2009 en relación al costo promedio del período 2006-2007-2008 fue de US$ 147 560 y de la consulta ambulatoria de US$ -56 048. Conclusiones. El período de estudio 2009 generó un costo mayor en relación al promedio de los años 2006-2007-2008, asociado al número de hospitalizaciones atribuibles a Infuenza A (pH1N1).

https://doi.org/10.5546/aap.2012.19 232 downloads

15.

Exposição ocupacional ao ruído e acidentes do trabalho
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Dias, Adriano

; Cordeiro, Ricardo

; Gonçalves, Cláudia Giglio de Oliveira

Cadernos de Saúde Pública

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oct 2006, Volume 22 N. 10 Pages 2125 - 2130

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo foi verificar se a exposição ocupacional ao ruído é um fator de risco relevante para acidentes do trabalho na cidade de Piracicaba, São Paulo, Brasil. Foi realizado um estudo caso-controle de base hospitalar. Os casos foram 600 trabalhadores entre 15 e 60 anos que sofreram acidentes ocupacionais típicos entre maio e outubro de 2004, atendidos na Central de Ortopedia e Traumatologia de Piracicaba. Os controles foram 822 trabalhadores entre 15 e 60 anos que sofreram acidente não ocupacional e receberam o primeiro atendimento no serviço ou foram trabalhadores acompanhantes dos acidentados. Foi ajustado um modelo de regressão logística múltipla, tendo como variável independente o acidente do trabalho, controlada por co-variáveis de interesse, entre elas a exposição ao ruído. Estimou-se que o risco de sofrer acidente do trabalho é cerca de duas vezes maior entre trabalhadores expostos ao ruído, controlado para diversas co-variáveis. A exposição ocupacional ao ruído não só deteriora a saúde auditiva do trabalhador, mas também se constitui em fator de risco para acidentes do trabalho.

The purpose of this study was to verify whether occupational noise exposure is a significant risk factor for work accidents in the city of Piracicaba, São Paulo State, Brazil. This hospital-based case-control study included 600 workers aged 15-60 who suffered typical occupational accidents between May and October 2004 and were seen at the Piracicaba Orthopedics and Trauma Center. The control group comprised 822 workers, aged 15-60, who were also seen at the Center, and either had a non-occupational accident or were accompanying someone who had suffered an accident. A multiple logistic regression model was adjusted with work accident as an independent variable, controlled by covariables of interest such as noise exposure. The risk of having a work accident was about twice as high among workers exposed to noise, after controlling for several covariables. Occupational noise exposure not only affected auditory health status but was also a risk factor for work accidents.

8373 downloads Cited 9 times in SciELO

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