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ABSTRACT The socio-environmental problems experienced by coastal zones have conditioned the emergence of some environmental management tools and approaches to try to provide interdisciplinary answers and solutions to them. The emergence of the Integrated Coastal Zone Management approach in the 1970s and its subsequent implementation throughout the world in the face of the challenges of sustainable development led the Cuban government to adopt it in the 1990s. One of the many ways used was the approval of a master's degree program for capacity building in this area of knowledge. This work is based on the importance of the Master's Program in Integrated Coastal Zone Management at the University of Cienfuegos "Carlos Rafael Rodríguez". This master's program seeks to train professionals whose research contributes to the understanding of the phenomena that occur in the coastal zone and its tributary basins; to identify problems related to the integrated management of coastal zones; and to recommend solutions, among other aspects. From the methodological point of view, an analysis was made of the progress of the academic program based on its theoretical, methodological and research foundations. It is concluded that coastal zones constitute a new field of research which requires the formation of interdisciplinary capacities to address the problems presented by these important complex and fragile spaces.

RESUMEN La problemática socioambiental que experimentan las zonas costeras, ha condicionado la aparición de algunas herramientas y enfoques de gestión ambiental para tratar de dar respuestas y soluciones interdisciplinares a ellas. El surgimiento del enfoque de Manejo Integrado de Zonas Costeras en la década del 70 del siglo XX y su posterior implementación por el mundo ante los desafíos del desarrollo sostenible hizo que el Estado cubano lo asumiera a partir de la década del 90. Una de tantas vías utilizadas fue la aprobación de un programa de maestría para la formación de capacidades en esta área del conocimiento. En este trabajo se fundamenta la importancia que tiene el Programa de Maestría en Manejo Integrado en Zonas Costeras que posee la Universidad de Cienfuegos “Carlos Rafael Rodríguez”. Este programa de maestría persigue la formación de profesionales cuyas investigaciones contribuyan a la comprensión de los fenómenos que ocurren en la zona costera y sus cuencas tributarias; a identificar problemas relacionados con el manejo integrado de las zonas costeras; y a recomendar soluciones, entre otros aspectos. Desde el punto de vista metodológico se realizó un análisis de los avances del programa académico a partir de sus fundamentos teóricos, metodológicos e investigativos. Se concluye que las zonas costeras constituyen un nuevo campo de investigaciones el cual requiere la formación de capacidades interdisciplinarias para el abordaje de los problemas que presentan estos importantes espacios complejos y frágiles.

Itinerários terapêuticos no cuidado em saúde em comunidades quilombolas
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Gomes, Rafael Fernandes

; Oliveira, Pâmela Scarlatt Durães

; Silva, Maria Luiza Oliveira

; Miranda, Sérgio Vinícius Cardoso de

; Sampaio, Cristina Andrade

Ciência & Saúde Coletiva

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2024, Volume 29 N. 3 elocation e01602023

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This article aimed to map therapeutic itineraries in health care within rural Quilombola communities in the north of Minas Gerais, Brazil. This is a section of a qualitative research conducted in six visited communities. The data was collected through 18 individual interviews, analyzed using the theoretical-methodological framework of Therapeutic Itineraries, and organized into three empirical themes. The narratives allowed for understanding the paths taken in health care by the Quilombola population, identifying the components of the popular subsystem (natural resources, the use of teas and home remedies), the family subsystem (transmission of knowledge and cultural heritage of care), and the professional subsystem (hospital level, medical care, primary and specialized attention). The difficulties of access are not only due to geographical distances, but also broader aspects of social determination, such as institutional racism, low availability of services, the need for payment for transportation and medical procedures. In this sense, it is necessary to have an approach and interventions from public policies to address ethnic-racial, economic, and access inequalities in health care services.

Resumo Este artigo teve como objetivo mapear os itinerários terapêuticos no cuidado em saúde em comunidades quilombolas rurais no norte de Minas Gerais, Brasil. Trata-se de um recorte de uma pesquisa qualitativa realizada em seis comunidades visitadas. Os dados foram produzidos por meio de 18 entrevistas individuais, analisados pelo referencial teórico-metodológico dos itinerários terapêuticos e organizados em três temas empíricos. As narrativas permitiram a compreensão dos percursos trilhados no cuidado em saúde pela população quilombola, a identificação dos componentes do subsistema popular (recursos naturais, o uso de chás e remédios caseiros), do subsistema familiar (transmissão de conhecimentos e herança cultural de cuidados), e do subsistema profissional (nível hospitalar, cuidados médicos, atenção primária e especializada). As dificuldades de acesso não decorrem apenas das distâncias geográficas, envolvem aspectos mais amplos da determinação social, como o racismo institucional, a baixa oferta de serviços, a necessidade de pagamento para deslocamentos e procedimentos médicos. Nesse sentido, fazem-se necessárias uma abordagem e intervenções das políticas públicas frente às desigualdades étnico-raciais, econômicas e de acesso aos serviços de cuidado em saúde.

https://doi.org/10.1590/1413-81232024293.01602023

Exercícios de dupla tarefa no equilíbrio, autonomia funcional e mobilidade dos idosos
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Silva, Paula Soares da

; Moreira, Evellyn de Oliveira

; Alencar, Flávia Rosa de

; Moura, Gabriel Tavares Macedo

; Barreto, Rafael de Oliveira Nogueira

; Miranda, Fábio Batista

Motricidade

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sep 2023, Volume 19 N. 3 Pages 331 - 338

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este estudo buscou verificar os efeitos dos exercícios de dupla tarefa no equilíbrio, autonomia funcional e mobilidade dos idosos. Trata-se de um estudo longitudinal, quase experimental, descritivo e quantitativo, sendo selecionados nove idosos que se enquadravam nos critérios de inclusão e exclusão, após aplicação do Mini exame do estado mental. Participaram do estudo dois idosos do sexo masculino e sete do sexo feminino, durante oito semanas, com frequência de dois dias alternados. Foram avaliadas as seguintes variáveis: teste de equilíbrio de Tinetti, Grupo de Desenvolvimento Latino-Americano para a Maturidade (GDLAM), Timed Up & Go (TUG), TUG manual 1 e 2 e TUG cognitivo 1 a 6. O valor de p< 0,05 foi adotado para a significância estatística. Não houve redução significativa no Timed Up & Go, TUG manual 1 e 2 e TUG cognitivo 1 a 6. Ocorreu aumento significativo de 1,11 pontos pós intervenção (p= 0,007) do teste de equilíbrio de Tinetti e uma diminuição significativa (6,14 segundos) os exercícios de C10m (p= 0,001), LPS (5,67 segundos) (p= 0,004) e VTC (4,79 segundos) (p= 0,003). Nota-se também uma redução significativa (8,88 pontos) (p= 0,001) do escore IG. Conclui-se através dos resultados obtidos na presente pesquisa que houve melhora significativa no desempenho do equilíbrio e autonomia funcional dos idosos. Através desses achados infere-se que os idosos da pesquisa terão uma melhor autonomia e menor risco de quedas.

ABSTRACT This study sought to verify the effects of dual-task exercises on balance, functional autonomy and mobility of the elderly. This longitudinal, quasi-experimental, descriptive and quantitative study selected 9 elderly people who met the inclusion and exclusion criteria. After applying the Mini Mental State Examination, two males and seven females participated in the study for eight weeks, with a frequency of two alternate days. The following variables were evaluated: Tinetti balance test, Latin American Development Group for Maturity (GDLAM), Timed Up & Go (TUG), manual TUG 1 and 2 and cognitive TUG 1 to 6. The p< 0.05 was adopted for statistical significance. There was no significant reduction in Timed Up & Go, manual TUG 1 and 2 and cognitive TUG 1 to 6. There was a significant increase of 1.11 points post-intervention (p= 0.007) of the Tinetti balance test and a significant decrease (6.14 seconds) in the C10m exercises (p= 0.001), LPS (5.67 seconds) (p= 0.004) and VTC (4.79 seconds) (p= 0.003). There was also a significant reduction (8.88 points) (p= 0.001) in the IG score. It is concluded through the results obtained in this research that there was a significant improvement in the performance of balance and functional autonomy of the elderly. These findings show that the elderly in the present research will have better autonomy and a lower risk of falls.

https://doi.org/10.6063/motricidade.31541

Cirugía de exéresis sobre la región externa de la pierna - reparos anatómicos
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Ojeda-Fiore, Hugo Antero

; Alvarenga-López, Carlos Tadeo

; González -Cárdenas, Mauricio Rafael

; Ojeda-Cueto, Miranda Marie

; Orrego-Bobadilla, Gabriela Elizabeth

Cirugía paraguaya

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aug 2023, Volume 47 N. 2 Pages 37 - 38

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT The presented case corresponds to a patient with a low-grade soft tissue tumor measuring 5 cm in the upper third of the right leg, on the lateral side. The surgical approach involved an appropriate wide resection. In relation to the study's objective of correlating the surgical approach for resecting a soft tissue tumor located on the outer side of the upper third of the leg with the anatomical compartmental and extracompartmental elements of the leg, an anatomical dissection was performed in the Descriptive Anatomy Department, focusing on the elements of the lateral compartment of the leg. During this dissection, the following structures were identified: the peroneal muscles, the lateral branch of the common peroneal nerve or external sciatic nerve, their relationships with the head of the right fibula, and their branches - the superficial and deep peroneal nerves.

Resumen El caso presentado corresponde a una paciente con un tumor de partes blandas del tercio superior de la pierna derecha, cara externa; de bajo grado de 5 cm. cuya cirugía tuvo un enfoque de resección amplia adecuada. En relación con el objetivo del trabajo de relacionar el abordaje quirúrgico de la resección de un tumor de partes blandas ubicado en la cara externa del tercio superior de la pierna con los elementos anatómicos compartimentales y extra compartimentales de la pierna, fue realizada una disección anatómica en la Cátedra de Anatomía descriptiva haciendo énfasis en los elementos del compartimiento lateral de la pierna, en donde fueron identificados: los músculos peroneos, la rama externa del nervio ciático externo o peroneo común, sus relaciones con la cabeza del peroné lado derecho y sus ramas: nervios peroneo superficial y profundo.

https://doi.org/10.18004/sopaci.2023.agosto.37

Clivaje derechas/izquierdas en los sistemas políticos centroamericanos de posguerra. Un análisis histórico comparado
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Miranda Delgado, Rafael Gustavo

Latinoamérica. Revista de estudios Latinoamericanos

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jun 2023, N. 76 Pages 173 - 200

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: el objetivo de la investigación es analizar la formación y contemporaneidad del clivaje derechas/izquierdas en los sistemas políticos centroamericanos de posguerra. La metodología a utilizar es el Análisis Histórico Comparado (AHC), La hipótesis guía del estudio es que el clivaje derechas/izquierdas, su constitución y su expresión contemporánea, es fundamental para entender la pluralidad política y la calidad democrática en general en los sistemas políticos centroamericanos de posguerra. En el artículo se afirma que en El Salvador, Guatemala y Nicaragua el clivaje derecha/izquierda ha tenido dificultades para expresarse de forma democrática. En una primera instancia se expresó en la guerra, para luego tener un balance divergente de éxitos y fracasos en la democratización de los actores.

Abstract: The aim of the research is to analyze the formation and contemporaneity of right/left cleavage in the Central American post-war political systems. The methodology to be used is the Comparative Historical Analysis (cha). The guiding hypothesis of the study is that the right/left cleavage, its constitution, and its contemporary expression, are fundamental to understanding political plurality and democratic quality in general in the postwar Central American political systems. The article states that in El Salvador, Guatemala, and Nicaragua, right/left cleavage has had difficulty expressing itself in a democratic manner. In the first instance, it was expressed in the war, to then have a divergent balance of successes and failures in the democratization of the actors.

https://doi.org/10.22201/cialc.24486914e.2023.76.57531

Poder y Relaciones Internacionales: la dimensión cooperativa
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Miranda Delgado, Rafael Gustavo

Revista Relaciones Internacionales

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jun 2023, Volume 96 N. 1 Pages 73 - 92

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El poder ha sido el motor de las relaciones internacionales, y es el concepto fundamental para su estudio. Las escuelas Realista y Neo - Realista han sido las dominantes en la disciplina de las Relaciones Internacionales y han entendido al poder de forma exclusivamente conflictual. Por ello, el objetivo de este artículo es analizar conceptual y empíricamente la dimensión cooperativa del poder. En el artículo se afirma que el orden global contemporáneo se distingue por ser uno más plural en agentes y temas, y que para poder comprender esta diversidad se necesita un concepto de poder más amplio, que incluya su dimensión cooperativa.

Abstract Power has been the engine of international relations and is the key concept for its study. The Realist and Neo-Realist schools have been the dominant ones in the discipline of International Relations and have understood the power in an exclusively conflictual way. Therefore, the aim of this article is to analyze the cooperative dimension of power conceptually and empirically. The article states that the contemporary Global Order is distinguished by being more plural in terms of agents and issues. Then, to understand this diversity, a broader concept of power is needed, which includes its cooperative dimension.

https://doi.org/10.15359/ri.96-1.3

Genetic Polymorphisms in COL1A2 gene and the Risk of Tendinopathy: Case-Control Study
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Lopes, Lucas Rafael

; Guimarães, João Antônio Matheus

; Amaral, Marcus Vinicius Galvão

; Pereira, Camili Gomes

; Wainchtock, Victor Soares

; Goes, Rodrigo Araujo

; Miranda, Vitor Almeida Ribeiro de

; Perini, Jamila Alessandra

Revista Brasileira de Ortopedia

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may 2023, Volume 58 N. 3 Pages 478 - 486

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective To evaluate the influence of polymorphisms on genes encoding type I collagen and the genetic susceptibility of tendinopathy. Methodology Case-control study involving 242 Brazilian athletes from different sports modalities (55 cases of tendinopathy and 187 controls). The polymorphisms COLIAI (rs1107946) and COLIA2 (rs412777, rs42524, and rs2621215) were analyzed by theTaqMansystem. Odds ratio(OR)withtheir 95% confidence intervals (CIs) were calculated using a nonconditional logistic regression model. Results The mean age was 24.0 ± 5.6 years old and 65.3% were men. Of the 55 cases of tendinopathy, 25.4% had > 1 affected tendon, the most frequent being patellar (56.3%), rotator cuff (30.9%) and elbow or hand flexors (30.9%). Age and amount of time of sports practice were associated with a higher chance of presenting tendinopathy (5 and 8 times, respectively). The frequency of variant alleles in control and case patients, respectively, was: COLIAI rs1107946 24.0 and 29.6%; COLIA2 rs412777 36.1 and 27.8%; rs42524 17.5 and 25.9%; and rs2621215 21.3 and 27.8%. After adjusting for confounding factors (age and years of sports practice), COLIA2 rs42524and rs2621215 polymorphisms were associated with increased risk of tendinopathy (OR = 5.5; 95% CI = 1.2-24.6 and OR = 3.9; IC95% = 1.1-13.5, respectively). The haplotype COLIA2 CGT was associated with low risk for disease development (OR = 0.5; 95%CI = 0.3-0.9). Conclusion Age (≥ 25 years old), time of sports practice (≥ 6years) and polymorphisms in the COLIA2 gene increased the risk of developing tendinopathy.

Resumo Objetivo Avaliar a influência de polimorfismos nos genes que codificam o colágeno tipo I e a suscetibilidade genética da tendinopatia. Metodologia Estudo caso-controle envolvendo 242 atletas brasileiros de diferentes modalidades esportivas (55 casos de tendinopatia e 187 controles). Os polimorfismos COL1A1 (rs1107946) e COL1A2 (rs412777, rs42524 e rs2621215) foram analisados pelo sistema TaqMan. As razões de chance (OR) com seus intervalos de confiança (IC) de 95% foram calculadas usando um modelo de regressão logística não-condicional. Resultados A média de idade foi de 24,0 ± 5,6 anos e 65,3% eram homens. Dos 55 casos de tendinopatia, 25,4% apresentaram mais de um tendão acometido, sendo os maisfrequentesopatelar(56,3%),omanguitorotador(30,9%)eodocotoveloou flexores das mãos (30,9%). A idade e o tempo de prática esportiva foram associados a uma maior chance de apresentar tendinopatia (5 e 8 vezes, respectivamente). A frequência dos alelos variantes nos controles e casos, respectivamente, foi: COL1A1 rs1107946 24,0 e 29,6%; COL1A2 rs412777 36,1 e 27,8%; rs42524 17,5 e 25,9%; e rs2621215 21,3 e 27,8%. Após ajuste pelos fatores de confundimento (idade e anos de práticas esportiva), os polimorfismos COL1A2 rs42524 e rs2621215 foram associados a um risco aumentado de tendinopatia (OR = 5,5; IC95% = 1,2-24,6 e OR = 3,9; IC95% = 1,1-13,5, respectivamente). O haplótipo COL1A2 CGT foi associado a um baixo risco para desenvolvimento da doença (OR = 0,5; IC95% = 0,3-0,9). Conclusão Aidade (> 25 anos), o tempo de prática esportiva (> 6 anos) e polimorfismos no gene COL1A2 aumentaram o risco de desenvolvimento da tendino-patia.

https://doi.org/10.1055/s-0042-1757959

Diseño computacional de diodos orgánicos emisores de luz (OLED) a partir de oligómeros derivados de tiazolo[5,4-d]tiazol con propiedades ópticas y electroconductoras
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Ensuncho, Adolfo E.

; Miranda, Rafael D.

; Lafont, Jennifer J.

Información tecnológica

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apr 2023, Volume 34 N. 2 Pages 1 - 10

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: En este estudio se evalúan las propiedades ópticas y electroconductoras de los oligómeros derivados del compuesto tiazolo[5,4-d]tiazol constituidos por 4, 6, 8, 10 y 20 unidades, respectivamente, mediante la teoría de los funcionales de la densidad (DFT) y funcionales de la densidad dependiente del tiempo (TD-DFT). Se calculan la brecha de energía prohibida (Eg), la afinidad electrónica (VAE), la energía de ionización (VIP), la dureza química y las propiedades ópticas como el espectro de emisión y osciladores de fuerza. Los espectros de emisión predichos muestran que la emisión del oligómero se registra con una intensidad alta dentro de la región visible correspondiente al verde en el espectro electromagnético. Se concluye que los oligómeros de tiazolo[5,4-d]tiazol son buenos candidatos para ser usados como material de transporte de carga o material emisor en el diseño de diodos orgánicos emisores de luz (OLED), debido a que muestran buenas propiedades de conducción eléctrica y de transporte de carga.

Abstract: This study assesses the optical and electroconductive properties of oligomers derived from the thiazolo[5,4-d]thiazole compound consisting of 4, 6, 8, 10, and 20 units, respectively, by applying the density functional theory (DFT) and the time-dependent density functional theory (TD-DFT). Band gap (Eg), electron affinity (VAE), ionization energy (VIP), chemical hardness, and optical properties such as emission spectrum and force oscillators are calculated. The predicted emission spectra show that the oligomer’s emission is recorded with high intensity within the green visible light region of the electromagnetic spectrum. It is concluded that thiazolo[5,4-d]thiazole oligomers are good candidates as charge transport material and as emitting material when designing organic light-emitting diodes (OLED) since they show appropriate emission properties, electrical conduction, and freight transport.

https://doi.org/10.4067/s0718-07642023000200001

Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
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Andrade, Guilherme Miranda

; Sesconetto, Lucas

; Silva, Rafael Benjamim Rosa da

; Santos, Gabriela Guimarães Rodrigues dos

; Kayano, Paulo Priante

; Baccaglini, Willy

; Bezerra, Murilo Borges

; Bianco, Bianca

; Lemos, Gustavo Caserta

; Carneiro, Arie

International braz j urol

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apr 2023, Volume 49 N. 2 Pages 233 - 242

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative complications. Materials and methods This retrospective study included patients who underwent radical prostatectomy. The time between biopsy and surgery, staging tests, final histopathological evaluation after surgery, lymphadenectomy rate, postoperative complications, and prostatic specific antigen (PSA) levels (initial and 30 days after surgery) were analyzed and compared in a group of patients before and during the pandemic period. Results We included 226 patients: 88 in the pre-pandemic period and 138 during the pandemic period. There was no statistically significant difference in mean age, body mass index, ASA, pathological locally advanced disease, the proportion of patients who underwent lymphadenectomy, and ISUP grade in the biopsy between the groups. Positive surgical margins, prostatic extracapsular extension, and PSA levels at 30 days were also similar between the groups. The mean time between medical consultation and surgery was longer in the pandemic period than in the pre-pandemic (124 vs. 107 days, p<0.001), and the mean time between biopsy and medical consultation (69.5 days vs. 114 days, p<0.001) and between biopsy and surgery (198.5 days vs. 228 days, p=0.013) was shorter during the pandemic. The incidence of severe early and late perioperative complications was similar between the periods. Conclusions There was no delay between diagnosis and treatment at our institution during the COVID-19 pandemic period. No worsening of the prostate cancer features was observed.

https://doi.org/10.1590/s1677-5538.ibju.2022.0393

10.

Utopia interditada: APS como antídoto contra a desdemocratização e a necropolítica neoliberal
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Agostini, Rafael

; Castro, Adriana Miranda de

Saúde em Debate

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mar 2023, Volume 47 N. 136 Pages 227 - 241

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este ensaio reflete sobre o desmonte de uma Atenção Primária à Saúde (APS) abrangente como etapa fundamental à desdemocratização que avança a passos largos no Brasil e no mundo nos últimos anos, sendo condição de possibilidade da consolidação de uma necropolítica neoliberal que busca se institucionalizar e silenciar quaisquer potências de vida. Ao mesmo tempo, este texto reafirma também que é por meio mesmo da APS que se pode inflexionar o timão – alterando a rota da barbárie para a qual se navega – em direção à utopia inspiradora do Sistema Único de Saúde e ao seu projeto civilizatório solidário e cidadão. Considerados os atributos e as diretrizes que fundam e organizam a APS brasileira e a concertação de vozes que enseja, esta reflexão propõe, por fim, que seja ali uma trincheira estratégica na luta para investir em uma sociedade efetivamente democrática, em que todos se reconheçam e afirmem como sujeitos políticos e de direitos em defesa da vida.

ABSTRACT This essay reflects on the dismantling of a comprehensive Primary Health Care (PHC) as a fundamental step in the de-democratization that has advanced in large steps both in Brazil and in the world in recent years. It asserts that this process is one of the conditions for the consolidation of a neoliberal necropolitics that seeks to institutionalize and silence any life potencies. At the same time, this text also reaffirms that it is through PHC itself that the helm can be inflected – altering the barbarism route to which we navigate – towards the inspiring utopia of the Unified Health System (SUS) and its solidary and citizen civilization project. Considering the attributes and guidelines that found and organize the Brazilian PHC and the concertation of voices that it entails, this reflection proposes, lastly, that PHC can be a strategic trench in the struggle to invest in an effectively democratic society, in which everyone recognizes and affirms themselves as political subjects, subjects who have rights, in defense of life.

https://doi.org/10.1590/0103-1104202313615

11.

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad limitada
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Cabrera-Miranda, Luis A.

; Lozano-Ruiz, Francisco J.

; Blake-Cerda, Mónika

; Corona-Cruz, José F.

; Sánchez-Reyes, Roberto

; Pérez-Álvarez, Sandra I.

; Díaz-García, Diego A.

; Álvarez-Bojórquez, Mario E.

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Bolaño-Guerra, Laura M.

; Maldonado-Magos, Federico

; Aldaco-Sarvide, Fernando

; Alvarado-Zermeño, Adriana

; Barajas-Figueroa, Luis J.

; Bautista-Aragón, Yolanda

; Bolaños-Morales, Francina V.

; Castillo-Ortega, Graciano

; Félix-Leyva, Jesús A.

; Gerson-Cwilich, Raquel

; Guzmán-de Alba, Enrique

; López-Galindo, Ángel A.

; Mariscal-Ramírez, Carlos

; Piñeiro-Retif, Rafael

; Ramos-Prudencio, Rubí

; Rodríguez-Cid, Jerónimo

; Silva-Bravo, Fernando

; Arrieta, Óscar

Gaceta mexicana de oncología

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mar 2023, Volume 22 N. 1 Pages 3 - 23

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP, enfermedad limitada, en México, basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración entre el Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensuaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad limitada, producto de las preguntas de trabajo. Se identificó y evaluó críticamente la evidencia científica que responde a cada una de dichas preguntas clínicas, antes de incorporarla a la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad limitada del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica en estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by rapid growth rate and development of distant metastases. Objectives: To guide and standardize the treatment of limited disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: Consensus recommendations were reached, both by the Delphi method and in remote meetings, for limited SCLC disease resulting from the same number of work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the guide. Conclusion: This guide provides clinical recommendations for the management of limited disease SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000121

12.

Utopia interditada: APS como antídoto contra a desdemocratização e a necropolítica neoliberal
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Agostini, Rafael

; Castro, Adriana Miranda de

Saúde em Debate

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mar 2023, Volume 47 N. 136 Pages 227 - 241

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/0103-1104202313615

13.

AS PAISAGENS DE MORTE E A COVID-19 NAS AMÉRICAS: AS RESPOSTAS NORMATIVAS DA COMISSÃO INTERAMERICANA DE DIREITOS HUMANOS EM TORNO DA VULNERABILIDADE-MORTE
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Marconi, Claudia

; Miranda, Rafael de Souza Nascimento

; Santos, Isabela Agostinelli dos

Lua Nova: Revista de Cultura e Política

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jan 2023, N. 118 Pages 167 - 194

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The article engages with the death landscapes of the Americas’ two largest democracies - Brazil and the United States - during the Covid-19 crisis, offering a conceptual tool entitled vulnerability-death binomial to consider the extent to which a politics of tragedy is a turning point in the ways institutional politics addresses vulnerability and death, emphasizing the work of the Inter-American Commission on Human Rights (IACHR). When analyzing the normative responses of IACHR, no articulation was found between vulnerability and death but, instead, a bifurcation of each. Although it reveals that there is not a normative interplay between vulnerability and death, the bifurcation does not mean a choice between binary paths. While the two democracies have raised institutional challenges, the IACHR deepened certain senses of vulnerability and a normative movement towards death: issues historically absent from the international basic structure and capable of challenging the international justice theory.

Resumo O artigo parte das paisagens de morte das duas maiores democracias das Américas - Brasil e Estados Unidos - na crise de covid-19, oferecendo uma engrenagem conceitual denominada binômio vulnerabilidade-morte para ponderar em que medida a política da tragédia é um ponto de inflexão no tratamento das vulnerabilidades e da morte na política institucional, enfatizando o trabalho da Comissão Interamericana de Direitos Humanos (CIDH). Analisando as respostas normativas da CIDH, percebeu-se não a articulação, mas a bifurcação da vulnerabilidade e da morte. Embora revele um não entrelaçamento normativo, a bifurcação não significa uma escolha entre caminhos binários. Ainda que as duas democracias das Américas tenham suscitado desafios institucionais, a CIDH revelou um aprofundamento do sentido da vulnerabilidade e empreendeu normativamente em torno da morte: questões historicamente ausentes da estrutura básica internacional e capazes de lançar um desafio produtivo para a teoria da justiça internacional.

https://doi.org/10.1590/0102-167194/118

14.

Nutritional, physiological, hematological, and biochemical responses of lambs fed increasing levels of Pornunça silage
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Amorim, Jaíne Santos

; Gois, Glayciane Costa

; Silva, Altiery Felix e

; Santos, Milenna Alves dos

; Figuêiredo, Priscila Izidro de

; Miranda, Juliana Oliveira de

; Rodrigues, Rafael Torres de Souza

; Araújo, Gherman Garcia Leal de

; Voltolini, Tadeu Vinhas

Scientia Agricola

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2023, Volume 80 elocation e20210037

Abstract: En | Text: En | PDF: En

ABSTRACT: Pornunça (Manihot sp.) is a potential forage to feed ruminants in drylands worldwide; however, evaluations of animal diets are necessary. This study assessed intake and digestibility of dry matter and nutrients, physiological responses, ingestive behavior, water intake, as well as hematological and biochemical responses of lambs fed diets containing increasing levels of Pornunça silage (PS) replacing Tifton-85 bermudagrass hay (Cynodon spp.). Treatments consisted of 0, 33, 66, and 100 % PS considering the roughage portion of the diet (% dry matter – DM). The experimental design was completely randomized with six replicates. Cyanide acid (HCN) levels in fresh Pornunça leaves were 207.7 mg kg−1 DM and 76.78 mg kg−1 DM in PS. Intake of DM and crude protein (CP), and neutral detergent fiber corrected for ash and protein (NDFap) increased linearly with increasing levels of PS in the diet. Digestibility of DM, NDF, and CP were higher with increasing levels of PS. Idle time decreased linearly, while water balance, water intake via food, and total water in feces increased with PS. Nitrogen balance, physiological, and hematological responses were not influenced by treatments, while the final alanine aminotransferase increased for lambs fed all diets evaluated. The PS up to 100 % of the roughage portion increased DM and nutrient intake and digestibility without altering physiological responses and the hematological and biochemical parameters, resulting in greater water intake via food.

https://doi.org/10.1590/1678-992x-2021-0037

15.

Performance and meat quality of Label Rouge chickens at different slaughter ages
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Faria, Peter Bitencourt

; Geraldo, Adriano

; Oliveira, Giulia Piva

; Marçal, Joanna Oliveira

; Miranda, José Rafael

; Moreira, Larissa Faria Silveira

; Almeida, Alexander Alexandre de

; Camargos, Rosiane de Souza

Ciência Rural

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2023, Volume 53 N. 4 elocation e20210616

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar os parâmetros de desempenho e as características de carcaça e qualidade da carne de frangos Label Rouge criados em sistema alternativo em função do aumento da idade de abate. O delineamento foi inteiramente casualizado (DIC) disposto em esquema fatorial (2x5), sendo dois sexos (macho e fêmea) e cinco idades de abate (70, 90, 120, 150 e 180 dias). Foram utilizadas 240 aves (Pescoço Pelado), sendo 120 fêmeas e 120 machos, sendo avaliados os parâmetros de desempenho, carcaça, físico-químicos, composição centesimal e fibra muscular. Com o aumento no tempo de produção houve efeitos dos períodos de produção e sexo em relação a variáveis de desempenho, com melhores resultados para os machos. Para os parâmetros de carcaça e físico-químicos, houve interação entre sexo e idade de abate, revelando comportamento diferenciado para machos e fêmeas com aumento da idade de abate. Para a composição centesimal e análise das fibras musculares, somente para extrato etéreo no peito foi verificado interação entre os fatores estudados. O aumento da idade proporcionou a obtenção de frangos com maiores pesos vivos e de carcaça ao abate com consequente redução dos índices de desempenho, além de menor rendimento de carcaça e maior deposição de gordura abdominal nas fêmeas. As fêmeas apresentam menor maciez na coxa e os machos no peito com aumento da idade de abate e, em ambos os cortes, ocorreu maior intensificação da cor, índice de vermelho e redução do brilho a partir de 90 dias ou em maiores idades de abate.

ABSTRACT: This study evaluated the performance parameters, carcass characteristics, and meat quality of Label Rouge chickens raised under an alternative system as a function of age at slaughter. The design was completely randomized with a 5×2 factorial arrangement, with slaughtering at five ages (70, 90, 120, 150, and 180 days) and two sexes. A total of 240 birds (Pescoço Pelado strain) were used, including 120 females and 120 males. Performance, carcass, physicochemical, proximate composition, and muscle fiber traits were evaluated. Rearing time and sex had significant effects on performance-related traits, with better results for males. The interaction between slaughter age and sex had a significant effect on the carcass and physicochemical parameters, which cause different responses in males and females with increasing slaughter age. For the proximate composition and muscle fiber analysis, the interaction between the parameters studied only had a significant effect on ether extract in the breast. The increase in age resulted in chickens with higher live and carcass weight at slaughter but lower performance indices. Females had lower carcass yield and greater deposition of abdominal fat. Females had lower tenderness in the drumstick and males in the breast with increasing slaughter age, and both cuts had more intense color and redness and reduced lightness starting at the slaughter age of 90 days.

https://doi.org/10.1590/0103-8478cr20210616

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