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au:MONTEIRO, DANIEL S.

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Unraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosa
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Barros, Elcio Daniel S.

; Monção Filho, Evaldo S.

; Fonseca, Mariluce G.

; Alves, Patrícia S.

; Santos, Antônia Laíres S.

; Feitosa, Chistiane M.

; Silva, Dulce Helena S.

; Costa, Pedro Mikael S.

; Pessoa, Cláudia

; Campos, Carmem D. L.

; Monteiro, Cristina A.

; Chaves, Mariana Helena

; Vieira Júnior, Gerardo M.

Journal of the Brazilian Chemical Society

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oct 2023, Volume 34 N. 10 Pages 1398 - 1409

Abstract: En | Text: En | PDF: En

Toads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piauí state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 µg mL-1) and prostate (IC50 = 1.6 µg mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 µg mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.

https://doi.org/10.21577/0103-5053.20230052

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency
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Andrade, Bruna M. R. de

; Valença, Eugenia H. O.

; Salvatori, Roberto

; Oliveira Neto, Luiz A.

; Souza, Anita H. O.

; Oliveira, Alaíde H. A.

; Oliveira, Mario C.P.

; Melo, Enaldo V.

; Carvalho, Susana de

; Sales, Neuza J

; Monteiro, Gisane C.

; Lima, José Marcel de

; Annunziato, Marcos Felipe Harder

; Mannis, Guilherme Daniel Breternitz

; Souza, Lucas E. de A.

; Goes, Yasmin D.

; Carvalho, Thayza S.

; Farias, Celiane de

; Santos, Michela P. dos

; Cardoso, Gabriela P. F.

; Sousa, Carla S. Pereira

; Santana, Julia Rodrigues

; Sales, Ester Almeida

; d’Avila, Jeferson Sampaio

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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apr 2022, Volume 66 N. 2 Pages 198 - 205

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: Currently, not much is known about the interactions between voice and growth hormone (GH). We have described large kindred with isolated GH deficiency (IGHD) due to a GHRH receptor mutation, resulting in severe short stature and high-pitched voice. These IGHD individuals have little interest in GH treatment, as they consider themselves “short long-lived people”, rather than patients. Interestingly, they report normal general quality of life, but they rate their Voice-Related Quality of Life (V-RQOL) as low. Here, we assessed the social and auditory-perceptual impacts of artistic-intervention voice therapy with semioccluded vocal tract exercises (SOVTE) and choral singing, on their voices. Material and methods: Seventeen GH-naïve adult IGHD individuals were enrolled in a single-arm interventional pre-post study with 13 weekly sessions of choir singing over 90 days. Outcome measures were V-RQOL scores, self-assessment of voice, and auditory-perceptual analysis (GRBAS scale, G: grade of the severity of dysphonia; R: roughness; B: breathiness; A: asthenia; and S: strain). Results: Marked improvements in total (p = 0.0001), physical (p = 0.0002), and socioemotional (p = 0.0001) V-RQOL scores and in self-assessment of voice (p = 0.004) were found. The general grades of vocal deviation (p = 0.0001), roughness (p = 0.0001), breathiness (p = 0.0001) and strain (p = 0.0001) exhibited accentuated reductions. Conclusions: Voice therapy with semioccluded vocal tract exercises and choral training improved social impact and perceptual voice assessments in IGHD subjects and markedly improved their voice-related quality of life. This is particularly important in a setting where GH replacement therapy is not widely accepted.

https://doi.org/10.20945/2359-3997000000449

Prevalence of dementia in long-term care institutions: a meta-analysis
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Fagundes, Daniel Ferreira

; Costa, Marcos Túlio

; Alves, Bárbara Bispo da Silva

; Benício, Maria Madalena Soares

; Vieira, Lanna Pinheiro

; Carneiro, Lara S. F.

; Nascimento, Osvaldo José Moreira

; Monteiro Junior, Renato Sobral

Jornal Brasileiro de Psiquiatria

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mar 2021, Volume 70 N. 1 Pages 59 - 67

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Esta revisão sistemática e metanálise objetiva estimar a prevalência de demência em instituições de longa permanência para idosos (ILPIs). Métodos: Utilizou-se o Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Artigos originais transversais e longitudinais publicados até julho de 2020 foram elegíveis para esta revisão. As buscas foram conduzidas por meio das bases de dados do PubMed/MedLine, Web of Science, Scopus e Science Direct. A prevalência geral e o intervalo de confiança foram estimados. A heterogeneidade foi calculada de acordo com o índice de heterogeneidade (I2). Resultados: Cento e setenta e cinco estudos foram encontrados em todas as bases de dados e 19 estudos foram analisados, resultando em uma prevalência geral de idosos com demência de 53% (IC 46-59%; p < 0,01) que habitam em ILPIs. Conclusão: A prevalência de demência é maior em idosos moradores de ILPIs que em idosos da população geral. Tal dado mostra uma realidade preocupante e que precisa ser modificada. Há necessidade de melhor entendimento dos elementos que causam esse aumento de demência nas ILPIs para direcionar ações para melhorar a qualidade de vida e a saúde dos idosos institucionalizados.

ABSTRACT Objective: This study comprises a systematic review and meta-analysis that aimed to estimate the prevalence of dementia in long-term care institutions (LTCIs). Methods: We used the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Original transversal and longitudinal articles published until July 2020 were eligible in this review. Databases PubMed/MedLine, Web of Science, Scopus and ScienceDirect were searched. Overall prevalence and confidence intervals were estimated. Heterogeneity was calculated according to the index of heterogeneity (I2). Results: One hundred seventy-five studies were found in all databases and 19 studies were meta-analyses, resulting in an overall prevalence of 53% (CI 46-59%; p < 0.01) of demented older adults living in LTCIs. Conclusion: Prevalence of dementia is higher in older adults living in LTCIs than those living in general communities. This data shows a worrying reality that needs to be changed. There is a need for a better understanding of the elements that cause this increase in dementia in LTCFs to direct actions to improve the quality of life and health of institutionalized elderly.

https://doi.org/10.1590/0047-2085000000298 1100 downloads

Hemodynamics and cardiac autonomic modulation after an acute concurrent exercise circuit in older individuals with pre- to established hypertension
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Cordeiro, Ricardo

; Mira, Pedro Augusto

; Monteiro, Walace

; Cunha, Felipe

; Laterza, Mateus C.

; Pescatello, Linda S.

; Martinez, Daniel G.

; Farinatti, Paulo

Clinics

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2021, Volume 76 elocation e1971

Abstract: En | Text: En | PDF: En

OBJECTIVES: Few studies have investigated whether post-exercise hypotension (PEH) after concurrent exercise (CEX) is related to changes in cardiac output (Q) and systemic vascular resistance (SVR) in older individuals. We tested whether PEH after a single bout of CEX circuits performed in open-access facilities at the Third Age Academies (TAA) in Rio de Janeiro City (Brazil) would be concomitant with decreased Q and SVR in individuals aged ≥60 years with prehypertension. Moreover, we assessed autonomic modulation as a potential mechanism underlying PEH. METHODS: Fourteen individuals (age, 65.8±0.9 y; systolic/diastolic blood pressure [SBP/DBP], 132.4±12.1/72.8±10.8 mmHg; with half of the patients taking antihypertensive medications) had their blood pressure (BP), heart rate (HR), Q, SVR, HR variability (HRV), and spontaneous baroreflex sensitivity (BRS) recorded before and 50 min after CEX (40-min circuit, including seven stations of alternate aerobic/resistance exercises at 60-70% HR reserve) and non-exercise control (CONT) sessions. The study protocol was registered in a World Health Organization-accredited office (Trial registration RBR-7BWVPJ). RESULTS: SBP (Δ=−14.2±13.1 mmHg, p=0.0001), DBP (Δ=−5.2±8.2 mmHg, p= 0.04), Q (Δ=−2.2±1.5 L/min, p=0.0001), and BRS (Δ=−3.5±2.6 ms/mmHg; p=0.05) decreased after CEX as compared with the CONT session. By contrast, the HR increased (Δ=9.4±7.2 bpm, p<0.0001), and SVR remained stable throughout the postexercise period as compared with the CONT session (Δ=0.10±0.22 AU, p=0.14). We found no significant difference between the CEX and CONT with respect to the HRV indexes reflecting autonomic modulation. CONCLUSION: CEX induced PEH in the older individuals with prehypertension status. At least in the first 50 min, PEH occurred parallel to the decreased Q and increased HR, while SVR was not different. The changes in autonomic outflow appeared to be unrelated to the acute cardiac and hemodynamic responses.

https://doi.org/10.6061/clinics/2021/e1971 808 downloads

SÍNTESE, CARACTERIZAÇÃO E ESTUDO DOS PARÂMETROS DE JUDD-OFELT DE COMPOSTOS β‑DICETONATOS DE Eu(III) OU Sm(III)
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Scapolan, Maria I. X.

; Oliveira, Daniel H. de

; Monteiro, Jorge H. S. K.

; Davolos, Marian R.

; Adati, Renata D.

Química Nova

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2021, Volume 44 N. 10 Pages 1261 - 1267

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The lanthanide complexes [Ln(bmdm)3(L)] where Ln(III) = Eu and Sm were synthesized successfully using the diketone (1-(4-methoxyphenyl)-3-(4-tert-butylphenyl) propane-1,3-dione) (bmdm) and (L) = 1,10-phenanthroline (phen), 2,2’-bipyridine (bipy) ligands. The coordination modes were determined as bidentate chelate by the FT-IR. The ground state geometry was determined using the Sparkle/AM1 implemented in MOPAC2016 package. Europium complexes exhibit the characteristic emission bands that arise from5D0→7FJ (J = 0-4); the presence of just one5D0→7F0 line transition means that this site is without the center of inversion. Samarium complexes display transitions at4G5/2→6HJ (J = 5/2; 7/2; 9/2 and 11/2), being the4G5/2→6H9/2 the most intense, indicating that the forced electric dipole mechanism is predominant when compared with the magnetic dipole ones. The intensity parameters Ω2 and Ω4 were calculated according to the emission spectra for Eu(III) and absorption spectra for Sm(III). The high Ω2 values demonstrated that the lanthanide ion in bipy or phen complexes is in a highly polarizable chemical environment. The emission lifetime (τ) increases compared with that of precursor aquo complexes, confirming that the non-radiative quenching is minimized. The low quantum efficiency is a result of NIR emissions and non-radiative transitions of Sm(III).

https://doi.org/10.21577/0100-4042.20170792

NDUFV1 mutations in complex I deficiency: Case reports and review of symptoms
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Zanette, Vanessa

; Valle, Daniel do

; Telles, Bruno Augusto

; Robinson, Alan J.

; Monteiro, Vaneisse

; Santos, Mara Lucia S. F.

; Souza, Ricardo Lehtonen R.

; Benincá, Cristiane

Genetics and Molecular Biology

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2021, Volume 44 N. 4 elocation e20210149

Abstract: En | Text: En | PDF: En

Abstract Mitochondrial complex I (CI) deficiency is the most common oxidative phosphorylation disorder described. It shows a wide range of phenotypes with poor correlation within genotypes. Herein we expand the clinics and genetics of CI deficiency in the brazilian population by reporting three patients with pathogenic (c.640G>A, c.1268C>T, c.1207dupG) and likely pathogenic (c.766C>T) variants in the NDUFV1 gene. We show the mutation c.766C>T associated with a childhood onset phenotype of hypotonia, muscle weakness, psychomotor regression, lethargy, dysphagia, and strabismus. Additionally, this mutation was found to be associated with headaches and exercise intolerance in adulthood. We also review reported pathogenic variants in NDUFV1 highlighting the wide phenotypic heterogeneity in CI deficiency.

https://doi.org/10.1590/1678-4685-gmb-2021-0149

The Influence of Different Ammonium Cations on the Optical Properties of Tetrakis GdIII and EuIII Complexes
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Adati, Renata D.

; Monteiro, Jorge H. S. K.

; Cardoso, Lucas P.

; Oliveira, Daniel H. de

; Jafelicci Jr., Miguel

; Davolos, Marian R.

Journal of the Brazilian Chemical Society

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aug 2019, Volume 30 N. 8 Pages 1707 - 1716

Abstract: En | Text: En | PDF: En

A series of tetrakis-β-diketonate Q+[Ln(β-dik)4]–, where Ln = GdIII or EuIII, Q = ammonium cations and β-dik = tta (2-thenoyltrifluoracetone) or bmdm (1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione) have been synthesized and characterized. The environment surrounding the EuIII ion depends on the lateral groups of the ligand and on the alkyl chains of the counter ion Q. The shortest lifetime (τ) = 0.29 ms, and lowest quantum efficiencies (η) = 24%, were obtained for (N(C12H25)2(CH3)2)+[Eu(bmdm)4]–, while (N(C4H9)4)+[Eu(bmdm)4]– has the longest τ = 1.04 ms and η = 90%. The Judd-Ofelt intensity parameters (Ω2 and Ω4) strongly changes for tta series pointing to stronger ion-dipole interactions between the –CF3 group with the ammonium cations. The agreement between the experimental results of photoluminescence and theoretical data suggests that the geometries optimized by the Sparkle model are correct. These results point to potential candidates for building up Langmuir-Blodgett (LB) luminescent films, since it is possible to maximize the intermolecular interactions and the photoluminescent properties of tetrakis LnIII complexes.

https://doi.org/10.21577/0103-5053.20190073 267 downloads

Biotic potential and reproductive parameters of Spodoptera eridania (Stoll) (Lepidoptera, Noctuidae) in the laboratory
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Montezano, Débora Goulart

; Specht, Alexandre

; Sosa-Gómez, Daniel Ricardo

; Roque-Specht, Vânia Ferreira

; Barros, Neiva Monteiro de

Revista Brasileira de Entomologia

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sep 2013, Volume 57 N. 3 Pages 340 - 345

Abstract: En | Text: En | PDF: En

Biotic potential and reprodutcive parameters of Spodoptera eridania (Stoll) (Lepidoptera, Noctuidae) in the laboratory: This study aimed to evaluate the biotic potential and reproductive parameters of Spodoptera eridania (Stoll, 1782) under controlled conditions (25 ± 1ºC, 70 ± 10% RH and 14 hour photophase). The longevity, pre-, post- and oviposition periods, fecundity and fertility of 15 couples was evaluated. The longevity of females (10.80 days) was not significantly higher than those of males (9.27 days). The mean durations of the pre, post and oviposition periods were 2.067, 0.600 and 8.133 days, respectively. The mean fecundity per female was 1,398 eggs and the mean fertility was 1,367.50 larvae. On average, females copulated 1.133 times. A strong positive correlation was observed between the number of mating and fecundity (r = 0.881, P <0.001). However a strong negative correlation was observed between the number of copulations and the duration of the pre-oviposition period (r = -0.826, P = 0.002) and longevity (r = -0.823, P = 0.001). The biotic potential of S. eridania was estimated at 1.894 x 10(25) individuals/female/year. The net reproductive rate (Ro) was 560.531 times per generation and the mean generation time (T) was 35.807 days. The intrinsic rate of increase (rm) was 0.177, with a finite rate of increase (l) of 1.193, per week

https://doi.org/10.1590/S0085-56262013005000026 3590 downloads Cited 6 times in SciELO

Marandu palisadegrass growth under nitrogen and sulphur for replacing signal grass in degraded tropical pasture
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Bona, Fabiano Daniel De

; Monteiro, Francisco Antonio

Scientia Agricola

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oct 2010, Volume 67 N. 5 Pages 570 - 578

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A degradação de pastagens formadas por plantas de Brachiaria decumbens Stapf. (capim-Braquiária) é um problema que assola os pecuaristas brasileiros. Avaliaram-se combinações de doses de nitrogênio (N) e de enxofre (S) na produção da Brachiaria brizantha (Hochst. ex A. Rich.) Stapf. cv. Marandu (capim-Marandu) em implantação em solo de área vegetada com capim-Braquiária em degradação, e as alterações nas concentrações desses elementos no tecido vegetal e no solo promovidas pela adubação com N e S. O experimento foi realizado em casa de vegetação em vasos contendo Neossolo Quartzarênico com expressivo teor de matéria orgânica. Avaliaram-se cinco doses de N (0; 100; 200; 300 e 400 mg dm-3) combinadas com cinco doses de S (0; 10; 20; 30 e 40 mg dm-3), em um fatorial 5² fracionado. Realizaram-se três cortes das plantas de capim-Marandu. A interação doses de N × doses de S na adubação foi significativa para as variáveis área foliar total, número de perfilhos, massa seca da parte aérea, concentração de N e relação N:S na planta, e teores de N total e enxofresulfato do solo em pelo menos um dos três crescimentos do capim-Marandu. A relação N:S no fertilizante em aproximadamente 10:1 propiciou elevada produção de massa seca, com concentrações de N e de S adequadas para o metabolismo da planta e produção de forragem, bem como manteve e/ou incrementou a fertilidade do solo em relação aos referidos nutrientes.

The degradation of Brachiaria decumbens Stapf. (Signal grass) pastures has resulted in a big problem for the Brazilian cattlemen. The objective of this study was to assess fertilization with nitrogen (N) and sulphur (S) rates on yield of Brachiaria brizantha (Hochst. ex A. Rich.) Stapf. cv. Marandu (Marandu palisadegrass) under establishment in a soil supporting degrading pasture of Brachiaria decumbens Stapf. Additionally, the N and S concentrations in plant tissue and soil according to the rates of these nutrients were evaluated. The study was carried out in a greenhouse in pots filled with an Entisol with high organic matter content. Five rates of N (0; 100; 200; 300 and 400 mg dm-3) and five rates of S (0; 10; 20; 30 and 40 mg dm-3) were tested in a 5² fractionated factorial. Plants were harvest three times. The interaction N rates × S rates was significant for the variables leaf area, tiller number, shoot dry matter, N concentration and N:S ratio in plants, and total N and sulphur-sulphate in the soil in at least one of the three growth periods of Marandu palisadegrass in establishment. The supply of both S and N to reach the N:S ratio about 10:1 in the fertilization promoted high yield, adequate N and S concentrations for plant metabolism and forage production, as well as kept and/or raised the soil fertility in relation to these nutrients.

3019 downloads Cited 1 time in SciELO

10.

Estrutura e celularidade de meniscos frescos de coelhos (Oryctolagus cuniculus) preservados em glicerina
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Vilela, Liana M.

; Del Carlo, Ricardo J.

; Silva, João Carlos P. da

; Da Matta, Sérgio Luís P.

; Rodrigues, Mauricio Correia D.

; Monteiro, Betânia S.

; Martinez, Mastoby Miguel M.

; Reis, Amanda Maria S.

; Machado, Daniel P. Dias

; Lopes, Liliane R.

Pesquisa Veterinária Brasileira

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apr 2010, Volume 30 N. 4 Pages 295 - 300

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

No presente estudo foi avaliada a arquitetura tecidual, a população celular, assim como a integridade e a distribuição dos tipos celulares em meniscos frescos de coelhos e preservados em glicerina 98%. Foram analisados meniscos mediais de coelhos recém abatidos, que foram distribuídos em três grupos: o grupo MF (n=7), composto por meniscos frescos, correspondeu ao grupo controle; o grupo MG (n=7), composto por meniscos preservados em glicerina 98%, por 30 dias, e o grupo MR (n=7), por meniscos preservados em glicerina 98% e reidratados em NaCl 0,9%, por 12 horas. Em todos os meniscos foram identificados e quantificados os diferentes tipos celulares: fibroblastos/fibrócitos e condrócitos. A população celular foi estatisticamente semelhante nos três grupos de meniscos, sendo que os meniscos preservados, grupos MG e MR, apresentaram menor intensidade de coloração e retração das fibras colágenas, diminuição de volume e maior intensidade de coloração dos núcleos (condensação da cromatina), em relação aos meniscos frescos (MF), caracterizando o fenômeno de lise celular. A matriz fibrocartilaginosa dos meniscos preservados revelou- se bem preservada mantendo a arquitetura tecidual dos meniscos. Conclui-se que a glicerina 98% é uma opção de meio de preservação para meniscos objetivando aloenxerto, com matriz colágena desvitalizada.

In the present study was evaluated the tissue architecture, the percentage of cellular population, as well as viability and distribution of cells in fresh menisci of rabbits and preserved in 98% glycerin. Were analyzed medial menisci of rabbits freshly slaughtered, which were distributed into three groups: the MF group (n=7), composed of fresh menisci, corresponded to the control group; the MG group (n=7), composed by menisci preserved in 98% glycerin, for 30 days, and the MR group (n=7) by menisci preserved in 98% glycerin and rehydrated in NaCl 0.9% for 12 hours. In all menisci were identified and quantified the different cell types: fibroblasts/fibrocytes and condrocytes. The cell population percentage was statistically similar in all groups. All menisci preserved in the MG and MR groups showed a lower intensity of color and shrinkage of collagen fibers, reduced volume and higher intensity of staining of nucleus (chromatin condensation), as compared to fresh menisci (MF), featuring the phenomenon of cell lysis. The cartilaginous matrix of preserved menisci proved to be well preserved because the tissue architecture was maintained. It was concluded that 98% glycerin is an optional preservation mean for meniscal allografts with a devitalized collagenous matrix.

2077 downloads

11.

Ocular metastasis as first presentation of renal cell carcinoma: report of 2 cases
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Pompeu, Antonio Carlos Lima

; Arap, Sami

; Silva, Matheus Neves R.

; Monteiro, Daniel S.

Clinics

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feb 2005, Volume 60 N. 1 Pages 75 - 78

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os autores apresentam dois casos de metástase ocular como o primeiro sinal que levou ao diagnóstico de carcinoma renal, uma apresentação incomum desta neoplasia. O primeiro paciente era um homem de 59 anos com uma massa no olho direito. O perfil histológico e imunohistoquimico demonstraram um provável carcinoma de células renais. A tomografia computadorizada revelou uma massa sólida no rim esquerdo, e o paciente foi submetido a nefrectomia radical esquerda, apresentando uma evolução sem complicações. O segundo paciente era um homem com 72 anos portador de uma lesão ulcerada na conjuntiva tarsal inferior direita. Uma biopsia excisional da lesão demonstrou um padrão histológico e imunohistoquimico de carcinoma de células renais. A tomografia de abdômen demonstrou um tumor periférico em rim direito, sendo o paciente submetido a nefrectomia radical. O carcinoma de células renais pode se apresentar atipicamente com metástases para órgãos incomuns. Nefrectomia pode ser útil em casos selecionados. As metástases oculares geralmente são excisadas por razoes estéticas e funcionais.

Authors report the cases of 2 patients who had an ocular lesion as the first sign leading to diagnosis of renal cell carcinoma, an uncommon presentation of this neoplasm. The first patient was a 59-year-old man presented with a mass in the right eye. The histological and immunohistochemical profile of the biopsy showed a probable renal cell carcinoma. A CT scan showed a solid mass in the left kidney. The patient underwent radical nephrectomy and excision of the ocular lesion and had an uneventful evolution. The second patient was a 72-year-old man presenting with an ulcerated lesion on the right inferior tarsal conjunctiva. An excisional biopsy of the lesion showed histological and immunohistochemical patterns of a clear cell carcinoma. Abdominal tomography disclosed a right peripheral renal tumor. A right radical nephrectomy was performed. Renal cell carcinoma may present atypically with metastases to quite uncommon organs. Nephrectomy may be of value in selected cases; the ocular metastases are usually excised for aesthetic and functional reasons.

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