Introdução : Meduloblastoma é um tumor maligno, altamente agressivo e de rápido crescimento que surge no cerebelo ou no assoalho do quarto ventrículo e tronco cerebral, especialmente em crianças. Mesmo com os avanços na terapia, a morbimortalidade permanece um grande desafio. Por isso, novos tratamentos são necessários para reduzir esses estágios. Objetivo : Revisar a relação NRP1 (neuropilina 1) e meduloblastoma como potencial alvo terapêutico e, também, com sobrevida global. Método : Trata-se de revisão narrativa realizada nas bases de dados PubMed e Scielo. A busca utilizou as seguintes palavras-chave: “ neuropilinas, meduloblastoma, tumores malignos, pediatria ”. Os critérios de inclusão foram artigos de revisão, estudos experimentais, pesquisas pré-clínicas e clínicas, em inglês e português, e disponíveis em texto completo. Os artigos selecionados foram analisados ​​com base nas tecnologias abordadas, perspectivas futuras e desafios conceituais, doenças referidas e ideia central do artigo. Resultado : Foram incluídos 30 artigos Conclusão : Os meduloblastomas possuem altos níveis transcricionais de neuropilina (NRP1) e seus baixos níveis relacionados com a menor sobrevida global, especialmente nos SHH. Nesse sentido, o NRP1 e seu complexo sistema de atuação aparecem como alvo potencial de terapias oncológicas para tumores específicos.

Introdução : O meduloblastoma é um tumor maligno, altamente agressivo e de rápido crescimento que surge no cerebelo ou no assoalho do quarto ventrículo e tronco encefálico, principalmente em crianças. Mesmo com os avanços na terapia, a morbidade e a mortalidade continuam sendo um grande desafio. Portanto, novos tratamentos são necessários para reduzir esses resultados. Objetivo : Revisar a relação NRP1 (neuropilina 1) e meduloblastoma como potencial alvo terapêutico e, também, com sobrevida global. Method: This is a narrative review carried out in the PubMed and Scielo databases. The search used the following keywords: “neuropilins, medulloblastoma, brain tumors, pediatrics”. The inclusion criteria were review articles, experimental studies, pre-clinical and clinical research, in English and Portuguese, and available in full text. The selected articles were analyzed based on the technologies covered, future perspectives and challenges mentioned, diseases mentioned and the central idea of the article. Result: 30 articles were included. Conclusion: Medulloblastomas have high transcriptional levels of neuropilin (NRP1) and their low levels are related to lower overall survival, especially in SHH. In this sense, NRP1 and its complex action system appear as a potential target for oncological therapies for brain tumors.

Introdução: O L-PRF é concentrado de plaquetas e leucócitos em rede de fibrina, obtido pela centrifugação autóloga coletada no momento da cirurgia. Faz parte da segunda geração de concentrados plaquetários, sendo de baixo custo, fácil preparo, simples obtenção e tem a capacidade de acelerar a cicatrização de tecidos moles e duros. Objetivo: Revisar o reparo ósseo de defeitos não críticos em calvária utilizando o L-PRF isoladamente e em associação com osso autógeno particulado. Método: Revisão integrativa da literatura retirada das plataformas SciELO, Pubmed e Scopus em inglês e português utilizando os seguintes descritores: “L-PRF, cicatrização óssea, defeitos em calvária. Coelhos” em AND ou OR pelo título ou resumo. Após a seleção apenas os artigos cosiderados pertinentes foram lidos na íntegra. Resultados: Foram incluídos 39 artigos. Conclusão: O L-PRF isoladamente teve efeito positivo na formação óssea no decorrer das semanas.

Introduction: L-PRF is a concentrate of platelets and leukocytes in a fibrin network, obtained by autologous centrifugation collected at the time of surgery. It is part of the second generation of platelet concentrates, being low cost, easy to prepare, simple to obtain and has the ability to accelerate the healing of soft and hard tissues. Objective: To review bone repair of non-critical calvarial defects using L-PRF alone and in association with particulated autogenous bone. Method: Integrative review of literature taken from the SciELO, Pubmed and Scopus platforms in English and Portuguese using the following descriptors: “L-PRF, bone healing, calvarial defects, rabbit” in AND or OR by the title or summary. After selection, only articles considered relevant were read in full. Results: 39 articles were included. Conclusion: L-PRF alone had a positive effect on bone formation over the weeks.

ABSTRACT Copper is an essential element for beet; however, it needs to be made available in adequate quantities since this nutrient, which is a heavy metal, can cause toxicity to plants and/or humans. This study aimed to evaluate the agronomic performance of beet fertigated with copper in a semi-arid region of Brazil. Two experiments were carried out in complete randomized blocks, with five treatments (0, 1.5, 3.0, 4.0, and 6.0 kg ha-1 of copper) and four replicates. In 2019, the copper content was within the adequate range for beet. In 2021, fertigation with copper above 0.8 kg ha-1 led to contents in the phytotoxicity range, which may explain the reduction in total and tuberous root dry mass accumulation. Fertilization with copper increased marketable yield in 2019 (17.32 t ha-1 at the dose of 3.9 kg ha-1 of copper), while, in 2021, there was no fit of the equations. Copper fertilization altered the tuberous root pH but did not influence the other tuberous root quality components. Plants fertilized with copper accumulated more copper in the leaves than in the tuberous root, with a maximum accumulation of 6.0 kg ha-1 of copper in 2019 and 2021. Fertilization with 3.9 kg ha-1 suits soils with low copper content.

RESUMO O cobre é um elemento essencial à beterraba, no entanto, é necessário disponibilizá-lo em quantidade adequada uma vez que esse nutriente, que é um metal pesado, pode causar toxicidade às plantas e, ou, ao ser humano. Esta pesquisa teve como objetivo avaliar o desempenho agronômico de beterraba fertirrigada com cobre em uma região semiárida do Brasil. Foram conduzidos dois experimentos em delineados em blocos casualizados ao acaso, com cinco tratamentos (0, 1.5, 3.0, 4.5 e 6.0 kg ha-1 de cobre) e quatro repetições. Em 2019, o teor de cobre estava dentro da faixa adequada para a beterraba. Em 2021, a fertirrigação com cobre acima de 0.8 kg ha-1 proporcionou teores na faixa de fitotoxicidade, o que pode explicar a redução no acúmulo de massa seca total e de raízes tuberosas. A adubação com cobre aumentou a produtividade comercial em 2019 (17.32 t ha-1 na dose de 3.9 kg ha-1 de cobre) enquanto que, em 2021, não houve modelo ajustado. A adubação alterou o pH da raiz tuberosa, mas não influenciou nos demais atributos de qualidade pós-colheita da raiz tuberosa. Plantas adubadas com cobre acumularam mais cobre nas folhas do que na raiz tuberosa, com máxima acumulada em 2019 e em 2021, na dose 6.0 kg ha-1 de cobre. A adubação com 3.9 kg ha-1 é adequada para solos com baixo teor de cobre.

Abstract The flotation mechanism of galena with xanthate as the collector is generally explained based on the mixed potential of the pulp, in which an anodic electron transfer reaction from the collector to the mineral is combined with an O2 cathodic reduction. Sodium sulphide, often used as a mineral activator, strongly influences the pulp's mixed potential, and depending on the dosage applied, it can become a galena depressor reagent. In this way, the current study assesses galena flotability in the absence of collector, as well as in the presence of the collector potassium amyl xanthate (PAX) and sodium sulphide. The effect of an extremely cathodic potential was also studied through the addition of hydrogen peroxide. In addition, the effect of different stages in the oxidation of the galena surface on the flotability was investigated. Moreover, the zeta potential was measured and contact angle (wettability) tests were carried out. The contact angle measurements were taken for a distilled water, PAX solution and for a mixture of PAX and sodium sulphide solution on the oxidized and non-oxidized surface of galena. All the results showed that galena could be floated in all the PAX concentrations tested. It was observed that a moderate oxidation in the galena surface may contribute to an improvement of its flotation with PAX. However, extremely anodic and cathodic potentials cause flotability close to zero. The zeta potential results showed that sodium sulphide affected the interaction between PAX and galena. The measurements of the contact angle corroborated the results obtained in the microflotation tests. pulp O reduction activator pulps s applied reagent way (PAX peroxide investigated Moreover wettability (wettability out water nonoxidized non tested However zero

Abstract Systemic Arterial Hypertension is a multifactorial clinical condition associated with severe outcomes such as stroke and death. One of the main modifiable risk factor for hypertension is an unhealthy diet, often characterized by the consumption of ultraprocessed foods such as sweetened beverages. We aimed to investigate the relationship between the consumption of sweetened beverages, both sugar-sweetened and artificially sweetened, and the prevalence of hypertension in adults. A cross-sectional, household, population-based study with 1,162 adults from two Brazilian cities were carried out. The consumption of food groups and sweetened beverages was obtained by food frequency questionnaire and other data were self-reported. Weight, height, and waist circumference were measured. The association between sweetened beverages consumption and hypertension was analyzed using Poisson regression models, expressed as Prevalence Ratio. The prevalence of hypertension was 16.7%, with no significant difference between genders. The prevalence of consumption of sweetened beverages was 70.3% in men and 54.6% in women, being significantly higher in men. Women who consumed sugar-sweetened and artificially sweetened beverages 6 to 7 days per week had 92% higher prevalence of hypertension compared to those who did not consume or consumed at a lower frequency. Furthermore, women who consumed artificially sweetened beverages at least 1 time per week had 3.36 times higher prevalence of hypertension. The habitual consumption of sweetened beverages may be an important risk factor for hypertension, especially the consumption of diet beverages, which are often marketed as healthier than sugar-sweetened beverages.

Resumen La Hipertensión Arterial Sistémica es una condición clínica multifactorial asociada a resultados graves como el ictus y la muerte. Uno de los principales factores de riesgo modificables de la hipertensión es una dieta poco saludable, a menudo caracterizada por el consumo de alimentos ultraprocesados como las bebidas endulzadas. Nuestro objetivo fue investigar la relación entre el consumo de bebidas endulzadas, tanto azucaradas como edulcoradas artificialmente, y la prevalencia de hipertensión en adultos. Se realizó un estudio transversal, domiciliario y poblacional con 1,162 adultos de dos ciudades brasileñas. El consumo de grupos de alimentos y bebidas endulzadas se obtuvo mediante cuestionario de frecuencia de alimentos y los demás datos fueron autoinformados. Se midieron el peso, la talla y el perímetro de la cintura. La asociación entre el consumo de bebidas endulzadas y la hipertensión se analizó mediante modelos de regresión de Poisson, expresados como Ratio de Prevalencia. La prevalencia de hipertensión fue del 16,7%, sin diferencias significativas entre géneros. La prevalencia de consumo de bebidas endulzadas fue del 70,3% en los hombres y del 54,6% en las mujeres, siendo significativamente mayor en los hombres. Las mujeres que consumían bebidas azucaradas y edulcoradas artificialmente entre 6 y 7 días a la semana tenían 92% mayor prevalencia de hipertensión que las que no consumían o consumían con una frecuencia menor. Además, las mujeres que consumían bebidas edulcoradas al menos 1 vez por semana tenían una prevalencia de hipertensión 3,36 veces mayor. Así pues, el consumo habitual de bebidas endulzadas puede ser un importante factor de riesgo de hipertensión, especialmente el consumo de bebidas dietéticas, que a menudo se comercializan como más saludables que las bebidas azucaradas.

Mantendo as distinções necessárias no contexto – ele foi alfabetizador no sertão brasileiro nas décadas de 60 a 80, ela foi uma intelectual europeia radicada no campo nos anos 40 –, eles cumpriram o mesmo papel na vida: educar para a liberdade e a libertação . E mostraram no além que suas obras serviram de farol para tantos que buscam na educação o vetor da transformação social e da libertação humana, numa luta árdua e sempre atual para tirar desta profissão o jugo da opressão, da ignorância e da alienação, criando assim, seja o “ser mais” freiriano, seja o cidadão weiliano crítico, emancipado e enraizado. O objetivo deste artigo é tentar um diálogo entre a pedagogia popular de Paulo Freire e a filosofia enraizada de Simone Weil.

Manteniendo las distinciones necesarias en contexto –él fue alfabetizador en el interior de Brasil en los años 60 y 80, ella era una intelectual europea arraigada en el campo en los años 40–, cumplieron el mismo papel en la vida: educar para la libertad y la liberación. Y demostraron en el más allá que sus obras sirvieron de faro para tantos que buscan en la educación el vector de transformación social y liberación humana, en una ardua y siempre actual lucha por quitar de esta profesión el yugo de la opresión, la ignorancia y la alienación. creando así, ya sea el “ser más” freiriano, o el ciudadano weiliano crítico, emancipado y arraigado. El objetivo de este artículo es intentar un diálogo entre la pedagogía popular de Paulo Freire y la arraigada filosofía de Simone Weil.

Guardadas as devidas distinções de contexto – ele alfabetizador no chão do sertão brasileiro nas décadas de 60 a 80, ela intelectual europeia enraizada no campo na década de 40 –, cumpriram em vida o mesmo papel: educar para a liberdade e a libertação. E mostraram pós-vida que seus trabalhos serviram de farol para tantos quantos buscam na educação o vetor de transformação social e libertação humana, numa luta árdua e sempre atual de retirar deste ofício o jugo da opressão, da ignorância e da alienação, criando assim, seja o “ser mais” freiriano, seja o cidadão crítico, emancipado e enraizado weiliano. O objetivo deste artigo é tentar um diálogo entre a pedagogia popular de Paulo Freire e a filosofia enraizada de Simone Weil.

Abstract Objective Evaluate autonomic function and low-grade inflammation and characterize the correlation between these variables in schoolchildren with obesity living in the Brazilian northeast region. Methods 84 children with obesity and 41 with normal weight were included in this cross-sectional study. Anthropometry, body composition, blood pressure (BP), inflammatory biomarkers, and heart rate variability (HRV) indexes were analyzed in children aged 7 to 11 years. Results children with obesity had increased systolic (p= 0.0017) and diastolic (p= 0.0131) BP and heart rate (p= 0.0022). The children with obesity displayed significantly lower SDNN, RMSSD, NN50, HF (ms), HF (nu), SD1, SD2, and higher LF (ms), LF (nu), LF/HF, SD1/SD2, DFA-α1, and DFA-α2, compared to normal weight. A lower and higher capacity for producing IL-10 (p= 0.039) and IL-2 (p= 0.009), respectively, were found in children with obesity compared to children with normal weight. Although IL-2, IL-4 and IL17A did not correlate with HRV parameters, IL-6 was positively correlated with SDNN, LF (ms) and SD2, TNF-α was positively correlated with LF/HF and SD1/SD2 ratio, and IFN-γ was positively correlated with SDNN, RMMSSD, NN50, LF (ms), HF (ms), SD1, and SD2. Conclusions The findings suggest that children with obesity have impaired autonomic function and systemic low-grade inflammation compared to children within the normal weight range, the inflammatory biomarkers were correlated with HRV parameters in schoolchildren living in the northeastern region of Brazil.

ABSTRACT The global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose.

RESUMO OBJETIVO Descrever e analisar a saudabilidade dos estabelecimentos com venda formal e informal de alimentos em terminais rodoviários da região metropolitana do Rio de Janeiro. MÉTODOS Realizou-se auditoria em 156 estabelecimentos formais e 127 pontos informais de venda de alimentos localizados em 14 terminais rodoviários das cinco cidades mais populosas da região metropolitana do Rio de Janeiro. Foram calculadas proporções de tipos de estabelecimentos e médias (IC95%) de indicadores de disponibilidade de alimentos nos ambientes formal e informal. Para o ambiente formal, foram descritos preços, proporções das formas de pagamento aceitas, dias e horários de funcionamento e categorias de alimentos com propaganda exposta. RESULTADOS A saudabilidade dos pontos de venda de alimentos nos terminais rodoviários era baixa (inferior a 36%). Em média, estavam disponíveis para compra 250% mais subgrupos de alimentos ultraprocessados do que in natura ou minimamente processados. Adquirir comida nesses locais era conveniente porque diversas formas de pagamento estavam disponíveis e os horários de funcionamento dos estabelecimentos acompanhavam os picos de movimentação. Além disso, 73,3% das propagandas se referiam a bebidas ultraprocessadas e o custo-benefício da compra de alimentos ultraprocessados era melhor que o de alimentos in natura ou minimamente processados. CONCLUSÃO O ambiente alimentar dos terminais rodoviários da região metropolitana do Rio de Janeiro promove uma alimentação não saudável. Políticas públicas de regulação devem se concentrar em iniciativas que limitem a ampla disponibilidade e publicidade de alimentos ultraprocessados nesses espaços de grande circulação de pessoas.

ABSTRACT PURPOSE To describe and analyze the healthiness of formal and informal food establishments in bus terminals of the metropolitan region of the state of Rio de Janeiro. METHOD An audit was conducted in 156 formal and 127 informal food establishments located in 14 bus terminals of the five most populous cities of the metropolitan region of Rio de Janeiro. Proportions of types of establishments and means (95%CI) of food availability indicators in formal and informal settings were calculated. For the formal setting, prices, proportions of accepted payment methods, days and hours of operation, and food categories with displayed advertising were described. RESULTS The healthiness of food establishments in bus terminals was low (less than 36%). On average, ultra-processed food subgroups were 250% more available for purchase than fresh or minimally processed food. Purchasing food at these places was convenient because several forms of payment were available, and the opening hours of the establishments followed the peaks of movement. In addition, 73.3% of the advertising referred to ultra-processed drinks, and the cost-benefit of buying ultra-processed food was better than fresh or minimally processed food. CONCLUSION The food environment of bus terminals in the metropolitan region of Rio de Janeiro promotes unhealthy eating. Regulatory public policies should focus on initiatives to limit the wide availability and advertising of ultra-processed food in spaces of great circulation of people.

RESUMEN Objetivo. Estimar la prevalencia del tracoma en poblaciones indígenas y no indígenas en determinadas zonas del estado de Maranhão, en el nordeste de Brasil. Métodos. Se trató de una encuesta de ámbito poblacional con muestreo probabilístico. Para el diagnóstico del tracoma, se realizó un examen ocular externo con una lupa frontal de 2,5X aumentos. Se estimó la prevalencia de la inflamación tracomatosa folicular (TF) en la población infantil de 1 a 9 años y la prevalencia de la triquiasis tracomatosa (TT) en la población de 15 años o más. Se obtuvieron las frecuencias relativas de las características sociodemográficas y ambientales. Resultados. En el estudio participaron 7 971 personas, 3 429 de poblaciones no indígenas y 4 542 de poblaciones indígenas. La prevalencia de la TF en las poblaciones no indígenas e indígenas fue de 0,1% y 2,9%, respectivamente, en tanto que la de la TT en las poblaciones indígenas fue de 0,1%. Conclusiones. La prevalencia de la TF y la TT en las dos unidades de evaluación del estado de Maranhão estuvo dentro de los límites recomendados para la eliminación del tracoma como problema de salud pública. Sin embargo, la prevalencia de la TF fue mayor en la unidad de evaluación indígena, lo que indica una mayor vulnerabilidad de esta población a la enfermedad. La prevalencia de la TF inferior al 5,0% implica una reducción de la transmisión, que puede haber sido consecuencia tanto de la mejora de las condiciones socioeconómicas como de la aplicación de la estrategia SAFE de la Organización Mundial de la Salud.

ABSTRACT Objective. To estimate the prevalence of trachoma in indigenous and non-indigenous populations in selected areas of the state of Maranhão, in northeastern Brazil. Methods. This was a population-based survey with probabilistic sampling. For the diagnosis of trachoma, external ocular examination was performed using head magnifying loupes, at 2.5X magnification. The prevalence of trachomatous inflammation – follicular (TF) in children aged 1–9 years and the prevalence of trachomatous trichiasis (TT) in the population aged ≥15 years were estimated. Relative frequencies of sociodemographic and environmental characteristics were obtained. Results. The study included 7 971 individuals, 3 429 from non-indigenous populations and 4 542 from indigenous populations. The prevalence of TF in non-indigenous and indigenous populations was 0.1% and 2.9%, respectively, and the prevalence of TT among indigenous populations was 0.1%. Conclusions. The prevalence of TF and TT in the two evaluation units in the state of Maranhão were within the limits recommended for the elimination of trachoma as a public health problem. However, the prevalence of TF was higher in the indigenous evaluation unit, indicating a greater vulnerability of this population to the disease. The prevalence of TF of below 5.0% implies a reduction in transmission, which may have resulted from improved socioeconomic conditions and/or the implementation of the World Health Organization SAFE strategy.

RESUMO Objetivo. Estimar a prevalência do tracoma em populações indígenas e não indígenas em áreas selecionadas do estado do Maranhão, na região Nordeste do Brasil. Métodos. Inquérito de base populacional com amostragem probabilística. Para o diagnóstico de tracoma, foi realizado exame ocular externo com o auxílio de lupas binoculares com ampliação de 2,5×. Foram estimadas a prevalência de inflamação tracomatosa folicular (TF) em crianças de 1 a 9 anos de idade e a prevalência de triquíase tracomatosa (TT) na população com idade ≥15 anos. Foram obtidas as frequências relativas das características sociodemográficas e ambientais. Resultados. O estudo incluiu 7 971 indivíduos (3 429 de populações não indígenas e 4 542 de populações indígenas). A prevalência de TF nas populações não indígenas e indígenas foi de 0,1% e 2,9%, respectivamente, e a prevalência de TT entre as populações indígenas foi de 0,1%. Conclusões. A prevalência de TF e TT nas duas unidades de avaliação no estado do Maranhão ficou dentro dos limites recomendados para a eliminação do tracoma como problema de saúde pública. No entanto, a prevalência de TF foi maior na unidade de avaliação indígena, indicando uma maior vulnerabilidade dessa população à doença. A prevalência de TF abaixo de 5,0% implica uma redução na transmissão, que pode ter sido resultado de melhores condições socioeconômicas e da implementação da estratégia SAFE da Organização Mundial da Saúde.

ABSTRACT: The present study described the prevalence and factors associated with the seropositivity for anti-Brucella spp. antibodies in working equids in the semiarid regionofnortheastern Brazil. Blood samples were collected from 322 equids (76 horses, 155 mules and 91 donkeys). The Rose Bengal plate test (RBPT) was used as a screening method. Samples that were reactive in the RBPT were tested for confirmation using 2-mercaptoethanol (2-ME) and the standard tube agglutination test (STAT). Overall, 7.1% (23/322) of the samples were positive according to the RBPT. After confirmatory tests, the prevalence of brucellosis was found to be 6.5% (21/322). Among these cases, 33.3% (7/21) were horses, 42.8% (9/21) were mules and 23.9% (5/21) were donkeys. In the multivariate analysis, age over 10 years was considered to be a factor associated with the seropositivity (OR: 17.17; 95% CI: 2.582-164.7, P = 0.006) for anti-Brucella spp. antibodies. The significant prevalence of anti-Brucella spp. antibodies found in working equids and the wide distribution of positive animals demonstrates a worrying epidemiological situation regarding brucellosis in the study region. Age over 10 years was a risk factor associated with the seropositivity for anti-Brucella spp. antibodies in animals.

RESUMO: O objetivo do presente estudo foi descrever a prevalência e os fatores associados à infecção por Brucellaspp. em equídeos de trabalho na região semiárida do Nordeste do Brasil. Amostras de sangue foram coletadas de 322 equídeos (76 equinos, 155 muares e 91 asininos). O teste de placa Rosa Bengala (RBPT) foi usado como método de triagem. As amostras que foram reativas no RBPT foram enviadas para confirmação usando 2-mercaptoetanol (2-ME) e o teste padrão de aglutinação em tubo (STAT). Ao todo, 7,1% (23/322) das amostras foram positivas segundo o RBPT. Após testes confirmatórios, a prevalência de brucelose foi de 6,5% (21/322). Destes casos, 33,3% (7/21) foram equinos, 42,8% (9/21) muares e 23,9% (5/21) asininos. Na análise multivariada, idade acima de 10 anos foi considerada fator associado à infecção (OR: 17,17; 95% CI: 2,582-164,7, P = 0.006) por Brucellas pp. A prevalência significativa de anticorpos anti-Brucella spp. encontrados em equídeos de trabalho e a ampla distribuição de animais positivos demonstra uma situação epidemiológica preocupante em relação à brucelose na região de estudo. A idade superior a 10 anos foi um fator de risco associado à infecção em animais.

ABSTRACT BACKGROUND: Considering the ability of the health and self-management in diabetes questionnaire (HASMID-10) to verify the impact of self-management on diabetes, we highlight its relevance to scientific research and clinical applicability. However, to date, no study has been conducted to scientifically support its use in other languages. OBJECTIVE: To translate, cross-culturally adapt, and validate the HASMID-10 into the Brazilian Portuguese. DESIGN AND SETTING: A translation, cross-cultural adaptation, and validation study conducted at Ceuma University. METHODS: Study was conducted in accordance with the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and Consensus-based Standards for the Selection of Health Measurement Instruments. We included participants of both sexes diagnosed with diabetes, aged between 18 and 64 years, and without cognitive deficits or any other limitations that would prevent them from answering the questionnaire. We assessed participants using the problem areas in diabetes (PAID) scale and HASMID-10. We assessed reliability using a test-retest model with a 7-day interval between assessments. We used intraclass correlation coefficient (ICC), 95% confidence interval (CI), standard error of measurement (SEM), minimum detectable difference (MDD), Spearman correlation coefficient, and floor and ceiling effects. RESULTS: Sample comprised 116 participants, most of whom were women, overweight, non-practitioners of physical activity, and nonsmokers. We observed significant correlations (P = 0.006; rho = −0.256) between the HASMID-10 and PAID, adequate reliability (ICC = 0.780) and internal consistency (Cronbach's alpha = 0.796). No ceiling or floor effects were observed. CONCLUSION: HASMID-10 has adequate measurement properties and may be used for Brazilians.

ABSTRACT: Scientific research on passion fruit has been conducted in several institutions worldwide, and it is of interest to the productive sector, the scientific community, and science and technology managers to learn about current scientific advances and opportunities through metric studies of bibliographic information. A survey of publications indexed in the Web of Science and the Agricultural Research Database-BDPA, in European Patent Office - Espacenet, and Embrapa’s technologies and projects were used as indicators to characterize research networks. This study analyzed the co-authorship and co-citation network of scientific production, the strength of connections among institutions, and a map of co-occurrence of keywords from 2001 to 2020. Brazil, the United States, Colombia, and France had the largest co-authorship networks for Passifloraceae. Brazilian institutions that are in a prominent position in the analysis of co-authorship networks and that produced the largest number of publications were Embrapa, University of São Paulo (USP), and State University of Campinas (Unicamp). The main themes studied were adsorption, antioxidant, clarification, evolution, flavonoid, flowering, growth, and somatic embryogenesis. Patents related to the use of passifloras were highest between 2015 and 2017 and were mainly focused on the production of food, beverages, cosmetics, and medicines. Brazil has relevant bibliographic production and technological development regarding passion fruit for the academic community and rural producers. These results integrated aspects of scientific activity that can help explore new research directions and explain the use and circulation of scientific production.

RESUMO: As pesquisas sobre o maracujá são realizadas em diversas instituições ao redor do mundo e é de interesse do setor produtivo, da comunidade científica e dos gestores de ciência e tecnologia, conhecer a dinâmica da ciência por meio de estudos métricos das informações bibliográficas. O levantamento das publicações indexadas na Web of Science e na Base de Dados de Pesquisa Agropecuária da Embrapa (BDPA), os registros no Escritório Europeu de Patentes - Espacenet, as tecnologias e os projetos da Embrapa foram utilizados como indicadores para caracterizar as redes de pesquisa sobre os maracujás. Este estudo analisou a rede de coautoria e cocitação da produção científica, a força de conexão entre as instituições e o mapa de coocorrência de palavras-chave entre 2001 e 2020. Brasil, Estados Unidos, Colômbia e França tiveram as maiores redes de coautoria em Passifloraceaes. As instituições brasileiras em posição de destaque na análise das redes de coautoria e que produziram o maior número de publicações foram Embrapa, USP e Unicamp. Os principais temas estudados foram adsorção, antioxidante, clarificação, evolução, flavonoide, floração, crescimento e embriogênese somática. As patentes relacionadas ao uso do maracujá tiveram destaque entre 2015 e 2017 com foco na produção de alimentos, bebidas, cosméticos e medicamentos. O Brasil possui relevante produção bibliográfica e desenvolvimento tecnológico sobre o maracujá tanto para a comunidade acadêmica quanto para os produtores rurais. Estes resultados integram aspectos da atividade científica que poderão prospectar novos direcionamentos de pesquisa e tornar conhecidos o uso e a circulação da produção científica.

ABSTRACT BACKGROUND: Precisely determining the aspects related to an instrument's validity and reliability measures allows for greater assurance of the quality of the results. OBJECTIVES: To analyze the psychometric properties of The Providers Survey in the Brazilian context of mental health services. DESIGN AND SETTING: The instrument validation study was conducted in Montes Claros, Minas Gerais, Brazil. METHODS: The validation study was conducted using the Consensus-based Standards for the Selection of Health Measurement Instruments checklist to analyze its validity and reliability. RESULTS: A committee of expert judges performed content validation after which the Content Validity Index was calculated. Construct validation took place through Exploratory Factor Analysis using the Kaiser-Meyer-Olkin Test criterion and Bartlett's Sphericity Test. Reliability was verified using test-retest reliability. The significance level adopted for the statistical tests was 5% (P < 0.05). The final instrument comprised 54 questions. The Content Validity Index was 97%. Exploratory Factor Analysis identified a Kaiser-Meyer-Olkin index of 0.901 and Bartlett's Sphericity Test with P < 0.001. We obtained a Cronbach's alpha coefficient of 0.95 and an intraclass correlation coefficient of 0.849. CONCLUSIONS: The Providers Survey, translated and adapted into Portuguese, was named the Work Assessment Instrument for the Recovery of Mental Health. It presented adequate psychometric properties for evaluating work-related practices for the recovery of psychosocial care network users.

ABSTRACT BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. OBJECTIVES: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. DESIGN AND SETTING: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. METHODS: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student’s t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. RESULTS: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. CONCLUSIONS: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases.