Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement

Karaca, Emine Esra; Kemer, Özlem Evren; Özek, Dilay; Berker, Dilek; Imga, Narin Nasiroglu

doi:10.5935/0004-2749.20200043

Acessibilidade / Reportar erro

Brasil

Arquivos Brasileiros de Oftalmologia

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

ORIGINAL ARTICLE • Arq. Bras. Oftalmol. 83 (4) • Jul-Aug 2020 • https://doi.org/10.5935/0004-2749.20200043 copy

Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement

Resultados clínicos da superfície ocular em pacientes tratados com reposição oral de vitamina D

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Purpose:

To analyze the clinical outcomes of the ocular surface in patients with vitamin D deficiency after oral replacement.

Methods:

A total of 40 patients with vitamin D deficiency were enrolled in the study. The patients received 50,000 units of oral vitamin D weekly over a period of 8 weeks. After 8 weeks, 1,500-2,000 units/d were administered for 24 weeks. Eyelid margin score, meibomian gland expressibility score, Oxford grading, Schirmer I test, tear breakup time, tear osmolarity, and the Ocular Surface Disease Index score were evaluated at baseline, and at 8, 12, and 24 weeks.

Results:

The meibomian gland expressibility score, Schirmer I, tear breakup time, tear osmolarity, and Ocular Surface Disease Index score showed improvement 8 weeks after vitamin D supplementation (p<0.05). Compared with the pretreatment values, the eyelid margin score and Oxford grading were decreased at week 12 (p<0.05).

Conclusion:

Vitamin D replacement appears to improve ocular surface in individuals with vitamin D deficiency.

Keywords:
Dry eye syndrome; Vitamin D deficiency; Dietary supplements

	Baseline	After vitamin D supplementation
	Baseline	8 weeks		12 weeks		24 weeks
	Mean ± SD	Mean ± SD	p-value	Mean ± SD	p-value	Mean ± SD	p-value
Eyelid margin score	1.65 ± 1.27	1.60 ± 1.24	0.160	1.33 ± 1.02	0.000^* * p<0.05 by paired t-test compared with baseline.	1.28 ±1.01	0.000^* * p<0.05 by paired t-test compared with baseline.
Meibomian gland expressibility score	0.93 ± 0.94	0.83 ± 0.81	0.044^* * p<0.05 by paired t-test compared with baseline.	0.73 ± 0.78	0.003^* * p<0.05 by paired t-test compared with baseline.	0.70 ± 0.79	0.005^* * p<0.05 by paired t-test compared with baseline.
Oxford grading	0.55 ± 0.68	0.43 ± 0.59	0.058	0.33 ± 0.57	0.002^* * p<0.05 by paired t-test compared with baseline.	0.33 ± 0.57	0.002^* * p<0.05 by paired t-test compared with baseline.
Schirmer I tear secretion test (mm)	13.10 ± 8.01	15.03 ± 7.80	0.002^* * p<0.05 by paired t-test compared with baseline.	16.55 ± 7.26	0.000^* * p<0.05 by paired t-test compared with baseline.	17.33 ± 7.29	0.000^* * p<0.05 by paired t-test compared with baseline.
TBUT (s)	5.53 ± 3.12	6.90 ± 2.72	0.000^* * p<0.05 by paired t-test compared with baseline.	8.30 ± 2.66	0.000^* * p<0.05 by paired t-test compared with baseline.	9.13 ± 3.01	0.000^* * p<0.05 by paired t-test compared with baseline.
Tear osmolarity	307.4 ± 15.4	304.1 ± 11.8	0.000^* * p<0.05 by paired t-test compared with baseline.	303.5 ± 12.1	0.000^* * p<0.05 by paired t-test compared with baseline.	302.7 ± 10.6	0.000^* * p<0.05 by paired t-test compared with baseline.
OSDI score	36.4 ± 22.1	27.40 ± 18.2	0.000^* * p<0.05 by paired t-test compared with baseline.	21.97 ± 13.9	0.000^* * p<0.05 by paired t-test compared with baseline.	19.12 ± 11.9	0.000^* * p<0.05 by paired t-test compared with baseline.

Conselho Brasileiro de Oftalmologia Rua Casa do Ator, 1117 - cj.21, 04546-004 São Paulo SP Brazil, Tel: 55 11 - 3266-4000, Fax: 55 11- 3171-0953 - São Paulo - SP - Brazil
E-mail: abo@cbo.com.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding author: Emine Esra Karaca. E-mail: emineesra@yahoo.com