Padrões de condução de impulsos nervosos, determinados eletronicamente, para análise de comportamento de nervos "in vivo"

Erhart, Eros Abrantes; Furlani, José; Berardi, Antonio Carlos; Bérzin, Fausto; Biazotto, Walter

doi:10.1590/S0004-282X1970000200003

Resumos

Padrões de condução de impulsos nervosos foram determinados eletrônicamente, in vivo, nos nervos ulnar (13), hipoglosso (16) e cutâneo medial do braço (7) de cães anestesiados. Os traçados obtidos confirmaram, em linhas gerais, os descritos na literatura. Todavia, demonstraram um fato novo, adicional, isto é, que fibras motoras e sensitivas, integrantes de nervos periféricos, apresentam uma condução específica, unidirecional (centrífuga nas fibras motoras e centrípeta nas sensitivas), desde que mantidas praticamente intactas em seus respectivos leitos conectivos naturais. Embora este tipo de condução específica corresponda ao que se admite e aceita como comportamento normal, biológico, dessas fibras nervosas, e constitua ainda, base do exame neurológico, esta evidência nunca foi demonstrada anteriormente em experiências e preparações neurofisiológicas.

Nerve conduction patterns of the ulnar, hypoglossal and medial brachial cutaneous nerves were determined and recorded electronically in vivo on anesthetized dogs. The recorded tracings obtained were generally found to be in accordance with those described in the literature. However, our tracings showed a new additional fact, i.e., that motor and sensory peripheral nerve fibers have a specific unidirectional conduction (centrifugally for motor and centripetally for sensory), as long as these nerves were maintained undisturbed in their natural connective tissue bed. Although these facts correspond to what is considered normal biological behavior of nerve fibers, when in their natural environment, as far as we know, this has not been demonstrated before in neurophysiological experiments.

Nerve conduction patterns determined electronically for analysing peripheral nerves behavior in vivo

Padrões de condução de impulsos nervosos, determinados eletronicamente, para análise de comportamento de nervos "in vivo"

Eros Abrantes Erhart^I; José Furlani^III; Antonio Carlos Berardi^II; Fausto Bérzin^IV; Walter Biazotto^IV

^IDepartamento de Anatomia da Universidade de São Paulo (Prof. O. Machado de Sousa): Professor Adjunto, Chefe da Secção de Neuranatomia

^IIDepartamento de Anatomia da Universidade de São Paulo (Prof. O. Machado de Sousa): Técnico em eletrônica

^IIIDepartamento de Anatomia da Universidade de São Paulo (Prof. O. Machado de Sousa): Assistente

^IVDepartamento de Anatomia da Universidade de São Paulo (Prof. O. Machado de Sousa): Instrutor

SUMMARY

Nerve conduction patterns of the ulnar, hypoglossal and medial brachial cutaneous nerves were determined and recorded electronically in vivo on anesthetized dogs. The recorded tracings obtained were generally found to be in accordance with those described in the literature. However, our tracings showed a new additional fact, i.e., that motor and sensory peripheral nerve fibers have a specific unidirectional conduction (centrifugally for motor and centripetally for sensory), as long as these nerves were maintained undisturbed in their natural connective tissue bed. Although these facts correspond to what is considered normal biological behavior of nerve fibers, when in their natural environment, as far as we know, this has not been demonstrated before in neurophysiological experiments.

RESUMO

Padrões de condução de impulsos nervosos foram determinados eletrônicamente, in vivo, nos nervos ulnar (13), hipoglosso (16) e cutâneo medial do braço (7) de cães anestesiados. Os traçados obtidos confirmaram, em linhas gerais, os descritos na literatura. Todavia, demonstraram um fato novo, adicional, isto é, que fibras motoras e sensitivas, integrantes de nervos periféricos, apresentam uma condução específica, unidirecional (centrífuga nas fibras motoras e centrípeta nas sensitivas), desde que mantidas praticamente intactas em seus respectivos leitos conectivos naturais. Embora este tipo de condução específica corresponda ao que se admite e aceita como comportamento normal, biológico, dessas fibras nervosas, e constitua ainda, base do exame neurológico, esta evidência nunca foi demonstrada anteriormente em experiências e preparações neurofisiológicas.

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Departamento de Anatomia Faculdade de Medicina da Universidade de São Paulo Caixa Postal 2921 São Paulo, SP Brasil.

Trabalho desenvolvido graças auxílio da Fundação de Amparo à Pesquisa do Estado de São Paulo (Proc. 68/475)

1. BOWMAN, J. & COMBS, C. M. Discharge patterns of lingual spindle afferent fibers in the hypoglossal nerve of the Rhesus monkey. Exptl. Neurol. 21:105, 1968.
2. BURGESS, P. R. & PERL, E. R. Myelinated afferent fibers responding specifically to noxious stimulation of the skin. J. Physiol. (London) 190:541, 1967.
3. ERHART, E. A. Normal nerve-fibres in the distal segment of nerves completely separated from the proximal stump for more than six months. Arq. Neuro-Psiquiat. (Săo Paulo) 20:289, 1962.
4. ERHART, E. A. & ERHART, M. B. Normal axis-cylinders in the distal segment of nerves completely separated from the proximal stump for up to 24 years. Anat. Rec. 136:189, 1960.
5. ERHART, E. A. & REZZE, C. J. Nerve fibres in isolated segments of dog ulnar nerve after complete brachial plexotomy and periaxilar artery sympathectomy. Arq. Neuro-Psiquiat. (Săo Paulo) 23:82, 1965.
6. ERHART, E. A. & REZZE, C. J. The neuroma-like structure of the longtime severed and isolated nerve stumps. Arq. Neuro-Psiquiat. (Săo Paulo) 23:91, 1965.
7. ERHART, E. A. & REZZE, C. J. Experimental data and practical results which modify the present concepts of peripheral nerve fibres degeneration and regeneration. Proc. V Internat. Congress of Neuropathol. (Zurich) p. 864-867, 1965. Published by Excerpta Medica.
8. ERHART, E. A. & REZZE, C. J. Effect of experimental devascularization on peripheral nerves. Arq. Neuro-Psiquiat. (Săo Paulo) 24:7, 1966.
9. ERHART, E. A. & REZZE, C. J. Further discussion on the newgroing nerve fibres which repopulate the distal segment of nerves completely separated from the proximal stump for more than six months. Arq. Neuro-Psiquiat. (Săo Paulo) 24:91, 1966.
10. ERHART, E. A.; REZZE, C. J. & BIAZOTTO, W. The ectopic newly-formed nerve fibres which repopulate the long-time denervated and atrophic chick skeletal muscle. Arq. Neuro-Psiquiat. (Săo Paulo) 26:187, 1968.
11. FOX, L. J. & KENMORE, P. The effect of ischemia on nerve conduction. Exptl. Neurol. 17:403, 1967.
12. LANDAU, M. L.; CLARE, M. H. & BISHOP, G. H. Reconstruction of myelinated nerve tract action potentials: an arithmetic method. Exptl. Neurol. 22:480, 1968.
13. LLINÁS, R.; NICHOLSON, C. & PRECHT, W. Preferred centripetal conduction of dendritic spikes in alligator Purkinje cells. Science, 163:184, 1969.
14. MC LEOD, J. G. & WRAY, S. H. Conduction velocity and fibre diameter of the median and ulnar nerves of the baboon. J. Neurol. Neurosurg. Psychiat. 30:240, 1967.
15. MORIMOTO, T.; TAKATA, M. & KAWAMURA, Y. Effect of lingual nerve stimulation on hypoglossus motoneurons. Exptl. Neurol. 22:174, 1968.
16. PAINTAL, A. S. A comparison of the nerve impulse of mammalian nonmedullated nerve fibers with those of the smallest diameter medullated fibers. J. Physiol. (London) 193:523, 1967.
17. ROBBINS, N. Peripheral modification of sensory nerve responses after cross-regeneration. J. Physiol. (London) 192:493, 1967.
18. WEISS, P. & EDDS, M. V. Jr. Sensory-motor nerve crosses in the rat. J. Neurophysiol. 8:173, 1945.

Datas de Publicação

Publicação nesta coleção
22 Abr 2013
Data do Fascículo
Jun 1970

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BOWMAN, J. & COMBS, C. M. Discharge patterns of lingual spindle afferent fibers in the hypoglossal nerve of the Rhesus monkey. Exptl. Neurol. 21:105, 1968.

[2] 2. BURGESS, P. R. & PERL, E. R. Myelinated afferent fibers responding specifically to noxious stimulation of the skin. J. Physiol. (London) 190:541, 1967.

[3] 3. ERHART, E. A. Normal nerve-fibres in the distal segment of nerves completely separated from the proximal stump for more than six months. Arq. Neuro-Psiquiat. (Săo Paulo) 20:289, 1962.

[4] 4. ERHART, E. A. & ERHART, M. B. Normal axis-cylinders in the distal segment of nerves completely separated from the proximal stump for up to 24 years. Anat. Rec. 136:189, 1960.

[5] 5. ERHART, E. A. & REZZE, C. J. Nerve fibres in isolated segments of dog ulnar nerve after complete brachial plexotomy and periaxilar artery sympathectomy. Arq. Neuro-Psiquiat. (Săo Paulo) 23:82, 1965.

[6] 6. ERHART, E. A. & REZZE, C. J. The neuroma-like structure of the longtime severed and isolated nerve stumps. Arq. Neuro-Psiquiat. (Săo Paulo) 23:91, 1965.

[7] 7. ERHART, E. A. & REZZE, C. J. Experimental data and practical results which modify the present concepts of peripheral nerve fibres degeneration and regeneration. Proc. V Internat. Congress of Neuropathol. (Zurich) p. 864-867, 1965. Published by Excerpta Medica.

[8] 8. ERHART, E. A. & REZZE, C. J. Effect of experimental devascularization on peripheral nerves. Arq. Neuro-Psiquiat. (Săo Paulo) 24:7, 1966.

[9] 9. ERHART, E. A. & REZZE, C. J. Further discussion on the newgroing nerve fibres which repopulate the distal segment of nerves completely separated from the proximal stump for more than six months. Arq. Neuro-Psiquiat. (Săo Paulo) 24:91, 1966.

[10] 10. ERHART, E. A.; REZZE, C. J. & BIAZOTTO, W. The ectopic newly-formed nerve fibres which repopulate the long-time denervated and atrophic chick skeletal muscle. Arq. Neuro-Psiquiat. (Săo Paulo) 26:187, 1968.

[11] 11. FOX, L. J. & KENMORE, P. The effect of ischemia on nerve conduction. Exptl. Neurol. 17:403, 1967.

[12] 12. LANDAU, M. L.; CLARE, M. H. & BISHOP, G. H. Reconstruction of myelinated nerve tract action potentials: an arithmetic method. Exptl. Neurol. 22:480, 1968.

[13] 13. LLINÁS, R.; NICHOLSON, C. & PRECHT, W. Preferred centripetal conduction of dendritic spikes in alligator Purkinje cells. Science, 163:184, 1969.

[14] 14. MC LEOD, J. G. & WRAY, S. H. Conduction velocity and fibre diameter of the median and ulnar nerves of the baboon. J. Neurol. Neurosurg. Psychiat. 30:240, 1967.

[15] 15. MORIMOTO, T.; TAKATA, M. & KAWAMURA, Y. Effect of lingual nerve stimulation on hypoglossus motoneurons. Exptl. Neurol. 22:174, 1968.

[16] 16. PAINTAL, A. S. A comparison of the nerve impulse of mammalian nonmedullated nerve fibers with those of the smallest diameter medullated fibers. J. Physiol. (London) 193:523, 1967.

[17] 17. ROBBINS, N. Peripheral modification of sensory nerve responses after cross-regeneration. J. Physiol. (London) 192:493, 1967.

[18] 18. WEISS, P. & EDDS, M. V. Jr. Sensory-motor nerve crosses in the rat. J. Neurophysiol. 8:173, 1945.

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Padrões de condução de impulsos nervosos, determinados eletronicamente, para análise de comportamento de nervos "in vivo"

Nerve conduction patterns determined electronically for analysing peripheral nerves behavior in vivo

Resumos

Datas de Publicação