Doenças e síndromes associadas à miastenia grave em um grupo de 304 pacientes

Assis, J. Lamartine de; Marchiori, Paulo E.; Zambon, Antonio A.; Scaff, Milberto

doi:10.1590/S0004-282X1984000300005

Resumos

Foram realizados estudos epidemiológico e clínico de doenças e síndromes associadas em um grupo de 304 pacientes miastênicos. Foram apresentadas projeções comparativas entre os casos presentes e os de outros autores.

Epidemiologic and clinic studies of both diseases and syndromes associated in a group of 304 myasthenic patients were made. A comparative projection between the present cases and those of other authors was presented.

Doenças e síndromes associadas à miastenia grave em um grupo de 304 pacientes

Myasthenia gravis and both syndromes and diseases associated in a group of 304 patients

J. Lamartine de Assis^I; Paulo E. Marchiori^III; Antonio A. Zambon^III; Milberto Scaff^II

^IProfessor Adjunto. Departamento de Neuropsiquiatria (Prof. Dr. Horácio Martins Canelas) da Faculdade de Medicina da Universidade de São Paulo (FMUSP)

^IIProfessor Livre Docente. Departamento de Neuropsiquiatria (Prof. Dr. Horácio Martins Canelas) da Faculdade de Medicina da Universidade de São Paulo (FMUSP)

^IIIMédico Assistente do Hospital das Clínicas, FMUSP

RESUMO

Foram realizados estudos epidemiológico e clínico de doenças e síndromes associadas em um grupo de 304 pacientes miastênicos. Foram apresentadas projeções comparativas entre os casos presentes e os de outros autores.

SUMMARY

Epidemiologic and clinic studies of both diseases and syndromes associated in a group of 304 myasthenic patients were made. A comparative projection between the present cases and those of other authors was presented.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Trabalho realizado no Serviço de Clínica Neurológica da Divisão de Neurologia do Departamento de Neuropsiquiatria (Prof. Dr. Horácio Martins Canelas) da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Clínica Neurológica, FMUSP - Caixa Postal 3461 - 01000, São Paulo, SP - Brasil.

1. ADNER, M. M.; SHERMAN, J. D; ISE, C; SCHWAB, R. S. & DAMESHEK, W. A. - An immunologic survey of 48 patients with myasthenia gravis. New Engl. J. Med. 271:1327, 1964.
2. AHARONOV, A.; ABRAMSKY, O.; TARRAB-HAZDAI, R. & FUCHS, S. - Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis. Lancet 1:340, 1975.
3. BOSCH, E. P.; REITH, P. E. & GRANNER, D. K. - Myasthenia gravis and Schmidt syndrome. Neurology (Minneapolis) 27:1179, 1977.
4. BOUDIN, C; LHUILLIER, M.; SHAISON, G..; PATRI, B. & GIRAULT, F. - Myasthenia, vitiligo, maladie de Basedow. Ann. Méd. int. 123:861, 1972.
5. GELD, H. VAN DER; FELTKAMP, T. E. W.; LOGHEM, J. J. VAN DER; OOSTERHUIS, H. J.G.H. & BIEMOND, A. - Multiple antibody production in myasthenia gravis. Lancet 2:373, 1963.
6. HAUSMANOWA-PETRUSEWICZ, I..; CHORZELSKI, T. & STRUGALSKA, H. - Three year observation of a myasthenic syndrome with other autoimmune syndromes in à patient with thymoma. J. neurol. Sci. 9:273, 1969.
7. KORNGUTH, S. E.; HANSON, J. C. & CHUN, R. W. M. - Antineuronal antibodies in patients having myasthenia gravis. Neurology (Minneapolis) 20:749, 1970.
8. LEFVERT, A. K.; BERSTRöM, K.; MATELL, G.; OSTERMAN, P. O. & PISHANER, R. - Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenic implications. J. Neurol. Neurosurg. Psychiat. 41:394, 1978.
9. LEONE, G,; TONALI, P.; TAVIANE, A. & LOVASTE, A. G. - Platelet autoantibodies in myasthenia gravis. New Engl. J. Med. 297:1402, 1977.
10. LINDSTROM, J. M.; SEYBOLD, M. E.; LENNON, V. A.; WHITTINGHAM, S. & DUANE, D. D. - Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value. Neurology (Minneapolis) 26:1054, 1976.
11. LISAK, R. P. & BARCHI, R. L. - Myasthenia Gravis. Saunders, Philadelphia, 1982.
12. MARSHALL, A. H. E. - Experimental thymic lesions resembling those of myasthenia gravis. Lancet 1:1030, 1961.
13. McFARLIN, D. E. - Myasthenia gravis. In M. Samter (ed.) - Immunological Diseases. Little-Brown, Boston, 1978. pg. 1383,
14. MILLIKAN, C. K. & HAINES, S. F. - The thyroid gland in relation to neuromuscular disease. Arch. int. Med. 92:5, 1953.
15. NAMBA, T.; NAKATA, U. & GROB, D. - The role of humoral and cellular immune factors in neuromuscular block in myasthenia gravis. Ann. N. T. Acad. Sci. 274:493, 1976.
16. NASTUK, W. L.; STRAUSS, A. J. L. & OSSERMAN, K. E. - Search for a neuromuscular blocking agent in the blood of patients with myasthenia gravis. Amer. J. Med. 26:394, 1959.
17. ODA, K.; GOTO, I.; KUROIWA, Y.; ONOUE, K. & ITO, Y. - Myasthenia gravis: antibodies to acetylcholine receptor with human and rat antigens. Neurology (NY) 30:543, 1980.
18. OOSTERHUIS, H. J. G. H. - Studies in myasthenia gravis: a clinical study of 180 patients. J. neurol. Sci. 1:512, 1964.
19. OOSTERHUIS, H. J. G. H. & HAAS, W. H. D. - Rheumatic diseases in patients with myasthenia gravis. An epidemiological and clinical investigation. Acta neurol. scand. 44:219, 1968.
20. OSSERMAN, K. E.; TSAIRIS, P. & WEINER, L. B. - Myasthenia gravis and thyroid disease: clinical and immunologic correlation. J. Mt. Sinai Hosp. 34:469, 1967.
21. OSSERMAN, K. E. - Myasthenia Gravis. Grune and Stratton, New York, 1958.
22. REZNIK, M. - Deux cas de syndrome myasthénique avec thymome, polymyosite, myocardite et thyroidite. J. neurol. Sci. 22:341, 1974.
23. ROWLAND, L. P. - Myasthenia gravis. In E. S. Goldensohn & S. H. Appel - Scientific Approaches to Clinical Neurology. Lea & Febiger, 1977, pg. 1018.
24. SAGAR, H. J.; GELSTHORPE, K.; WARD-MIFORD, A. & DAVIES-JONES, G. A. B. - Clinical and immunological associations in myasthenia gravis. I: autoantibodies. J. Neurol. Neurosurg. Psychiat. 43:967, 1980.
25. SAMMAN, P. D. - Ulcerative colitis, myasthenia gravis, atopical lichen planus, alopecia areata, vitiligo. Proc. roy. Soc. Med. 67:195, 1974.
26. SIMPSON, J. A. - Myasthenia gravis: a new hypothesis. Scott, med. J. 5:419, 1960.
27. SIMPSON, J. A. - Myasthenia gravis as an autoimmune disease: clinical aspects. Ann. N. Y. Acad. Sci. 135:506, 1966.
28. SIMPSON, J. F.; WESTERBERG, M. R. & MAGER, K. R. - Myasthenia gravis. An analysis of 295 cases. Acta neurol. scand. 42 (suppl. 23), 1966.
29. STRAUSS, A. J. L.; SEEGAL, B. C; HSU, K. C; BURHOLDER, P. M.; NASTUK, W. L. & OSSERMAN, K. E. - Immunofluorescence demonstration of a muscle binding complement-fixing serum globulin fraction in myasthenia gravis. Proc. Soc. exp. Biol. 105:184, 1960.
30. WHITTINGHAM, S. & MACKAY, I. R. - The pemphigus antibody and immunopathies affecting the thymus. Brit. J. Derm. 84:1, 1971.
31. WOLF, M. S.; ROWLAND, P. L.; SCHOTLAND, L. D.; MCKINNEY, S. A.; HOEFER, A. F. P. & ARANOW Jr., H. - Myasthenia as an autoimmune disease: clinical aspects. Ann. N. Y. Acad. Sci. 135:517, 1966.

Datas de Publicação

Publicação nesta coleção
14 Ago 2012
Data do Fascículo
Set 1984

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ADNER, M. M.; SHERMAN, J. D; ISE, C; SCHWAB, R. S. & DAMESHEK, W. A. - An immunologic survey of 48 patients with myasthenia gravis. New Engl. J. Med. 271:1327, 1964.

[2] 2. AHARONOV, A.; ABRAMSKY, O.; TARRAB-HAZDAI, R. & FUCHS, S. - Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis. Lancet 1:340, 1975.

[3] 3. BOSCH, E. P.; REITH, P. E. & GRANNER, D. K. - Myasthenia gravis and Schmidt syndrome. Neurology (Minneapolis) 27:1179, 1977.

[4] 4. BOUDIN, C; LHUILLIER, M.; SHAISON, G..; PATRI, B. & GIRAULT, F. - Myasthenia, vitiligo, maladie de Basedow. Ann. Méd. int. 123:861, 1972.

[5] 5. GELD, H. VAN DER; FELTKAMP, T. E. W.; LOGHEM, J. J. VAN DER; OOSTERHUIS, H. J.G.H. & BIEMOND, A. - Multiple antibody production in myasthenia gravis. Lancet 2:373, 1963.

[6] 6. HAUSMANOWA-PETRUSEWICZ, I..; CHORZELSKI, T. & STRUGALSKA, H. - Three year observation of a myasthenic syndrome with other autoimmune syndromes in à patient with thymoma. J. neurol. Sci. 9:273, 1969.

[7] 7. KORNGUTH, S. E.; HANSON, J. C. & CHUN, R. W. M. - Antineuronal antibodies in patients having myasthenia gravis. Neurology (Minneapolis) 20:749, 1970.

[8] 8. LEFVERT, A. K.; BERSTRöM, K.; MATELL, G.; OSTERMAN, P. O. & PISHANER, R. - Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenic implications. J. Neurol. Neurosurg. Psychiat. 41:394, 1978.

[9] 9. LEONE, G,; TONALI, P.; TAVIANE, A. & LOVASTE, A. G. - Platelet autoantibodies in myasthenia gravis. New Engl. J. Med. 297:1402, 1977.

[10] 10. LINDSTROM, J. M.; SEYBOLD, M. E.; LENNON, V. A.; WHITTINGHAM, S. & DUANE, D. D. - Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value. Neurology (Minneapolis) 26:1054, 1976.

[11] 11. LISAK, R. P. & BARCHI, R. L. - Myasthenia Gravis. Saunders, Philadelphia, 1982.

[12] 12. MARSHALL, A. H. E. - Experimental thymic lesions resembling those of myasthenia gravis. Lancet 1:1030, 1961.

[13] 13. McFARLIN, D. E. - Myasthenia gravis. In M. Samter (ed.) - Immunological Diseases. Little-Brown, Boston, 1978. pg. 1383,

[14] 14. MILLIKAN, C. K. & HAINES, S. F. - The thyroid gland in relation to neuromuscular disease. Arch. int. Med. 92:5, 1953.

[15] 15. NAMBA, T.; NAKATA, U. & GROB, D. - The role of humoral and cellular immune factors in neuromuscular block in myasthenia gravis. Ann. N. T. Acad. Sci. 274:493, 1976.

[16] 16. NASTUK, W. L.; STRAUSS, A. J. L. & OSSERMAN, K. E. - Search for a neuromuscular blocking agent in the blood of patients with myasthenia gravis. Amer. J. Med. 26:394, 1959.

[17] 17. ODA, K.; GOTO, I.; KUROIWA, Y.; ONOUE, K. & ITO, Y. - Myasthenia gravis: antibodies to acetylcholine receptor with human and rat antigens. Neurology (NY) 30:543, 1980.

[18] 18. OOSTERHUIS, H. J. G. H. - Studies in myasthenia gravis: a clinical study of 180 patients. J. neurol. Sci. 1:512, 1964.

[19] 19. OOSTERHUIS, H. J. G. H. & HAAS, W. H. D. - Rheumatic diseases in patients with myasthenia gravis. An epidemiological and clinical investigation. Acta neurol. scand. 44:219, 1968.

[20] 20. OSSERMAN, K. E.; TSAIRIS, P. & WEINER, L. B. - Myasthenia gravis and thyroid disease: clinical and immunologic correlation. J. Mt. Sinai Hosp. 34:469, 1967.

[21] 21. OSSERMAN, K. E. - Myasthenia Gravis. Grune and Stratton, New York, 1958.

[22] 22. REZNIK, M. - Deux cas de syndrome myasthénique avec thymome, polymyosite, myocardite et thyroidite. J. neurol. Sci. 22:341, 1974.

[23] 23. ROWLAND, L. P. - Myasthenia gravis. In E. S. Goldensohn & S. H. Appel - Scientific Approaches to Clinical Neurology. Lea & Febiger, 1977, pg. 1018.

[24] 24. SAGAR, H. J.; GELSTHORPE, K.; WARD-MIFORD, A. & DAVIES-JONES, G. A. B. - Clinical and immunological associations in myasthenia gravis. I: autoantibodies. J. Neurol. Neurosurg. Psychiat. 43:967, 1980.

[25] 25. SAMMAN, P. D. - Ulcerative colitis, myasthenia gravis, atopical lichen planus, alopecia areata, vitiligo. Proc. roy. Soc. Med. 67:195, 1974.

[26] 26. SIMPSON, J. A. - Myasthenia gravis: a new hypothesis. Scott, med. J. 5:419, 1960.

[27] 27. SIMPSON, J. A. - Myasthenia gravis as an autoimmune disease: clinical aspects. Ann. N. Y. Acad. Sci. 135:506, 1966.

[28] 28. SIMPSON, J. F.; WESTERBERG, M. R. & MAGER, K. R. - Myasthenia gravis. An analysis of 295 cases. Acta neurol. scand. 42 (suppl. 23), 1966.

[29] 29. STRAUSS, A. J. L.; SEEGAL, B. C; HSU, K. C; BURHOLDER, P. M.; NASTUK, W. L. & OSSERMAN, K. E. - Immunofluorescence demonstration of a muscle binding complement-fixing serum globulin fraction in myasthenia gravis. Proc. Soc. exp. Biol. 105:184, 1960.

[30] 30. WHITTINGHAM, S. & MACKAY, I. R. - The pemphigus antibody and immunopathies affecting the thymus. Brit. J. Derm. 84:1, 1971.

[31] 31. WOLF, M. S.; ROWLAND, P. L.; SCHOTLAND, L. D.; MCKINNEY, S. A.; HOEFER, A. F. P. & ARANOW Jr., H. - Myasthenia as an autoimmune disease: clinical aspects. Ann. N. Y. Acad. Sci. 135:517, 1966.