Parkinsonismo induzido pela flunarizina: a propósito de um caso

Galhardo, Ivanidton; Coutinho, Marcos Otávio de M.; Albuquerque, Eliedna S. de; Medeiros, Lilianny de O.

doi:10.1590/S0004-282X1993000400022

Resumos

Os autores registram o caso de uma paciente com parkinsonismo induzido pela flunarizina. Ressaltam um aspecto importante, relacionado ao tremor, que assumia características wilsonianas quando realizava a prova índice-nariz. A depressão foi sintoma importante. A cura se efetivou pela retirada da droga e pelo uso de levodopa e de tremaril por período de três meses.

parkinsonismo; flunarizina; intoxicação por drogas

The authors report the case of a female patient with parkinsonism induced by flunarizine, and refer the tremor to be of parkinsonian and also of wilsonian type. Cure was observed within three months, after withdrawal of flunarizine, and the use of L-dopa and biperiden.

parkinsonism; flunarizine; drug intoxication

Parkinsonismo induzido pela flunarizina: a propósito de um caso

Parkinsonism induced by flunarizine: case report

Ivanidton Galhardo^I; Marcos Otávio de M. Coutinho^II; Eliedna S. de Albuquerque^III; Lilianny de O. Medeiros^III

^IProfessor Adjunto IV, Chefe do Serviço de Neurologia do Departamento de Medicina Clínica (DMC), Coordenador da Disciplina de Neurologia (DN) do Centro de Ciências da Saúde (CCS) da Universidade Federal do Rio Grande do Norte (UFRN)

^IIProfessor Adjunto II, DN, CCS, UFRN

^IIIAluna regularmente matriculada no Curso Médico do CCS (DMC), UFRN

RESUMO

Os autores registram o caso de uma paciente com parkinsonismo induzido pela flunarizina. Ressaltam um aspecto importante, relacionado ao tremor, que assumia características wilsonianas quando realizava a prova índice-nariz. A depressão foi sintoma importante. A cura se efetivou pela retirada da droga e pelo uso de levodopa e de tremaril por período de três meses.

Palavras-chave: parkinsonismo, flunarizina, intoxicação por drogas.

SUMMARY

The authors report the case of a female patient with parkinsonism induced by flunarizine, and refer the tremor to be of parkinsonian and also of wilsonian type. Cure was observed within three months, after withdrawal of flunarizine, and the use of L-dopa and biperiden.

Key words: parkinsonism, flunarizine, drug intoxication.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Aceite : 15-março-1993.

Dr. Ivanilton Galhardo Rua Joaquim Câmara 229 - 59015-270 Natal RN - Brasil.

1. Bamrach JS, Soni SD. Drug induced Parkinson's disease. Lancet 1987, 2:1031.
2. Benvenutti F, Baroni A, Bandinelli S, Ferrucci L, Corradetti R, Pantaleo T. Flunarizine-induced parkinsonism in the elderly. J Clin Pharmacol 1988, 28:600-608.
3. Bezerra JMP, Andrade LAF, Ferraz HB, Arouca EM, Gonçalves SA, Borges V, Mendes MF. Síndrome parkinsoniana induzida pela flunarizina e cinarizina. Arq Neuropsiquiatr 1988, 46(Supl): 348.
4. Calne DB, Langston JW. Aetiology of Parkinson's disease. Lancet 1983, 2:1457.
5. Capela D, Laport JR, Caste JM, Tristan C, Cos A, Olivas FJM. Parkinsonism, tremor and depression induced by flunarizine. Br Med J 1988, 297.
6. Chouza C, Scaramelli A, Caamano JL, De Medina O, Romero S, Aljanati R. Parkinsonism, tardive dyskinesia, akathisia and depression induced by flunarizine. Lancet 1986, 1303-1304.
7. Fontanari JL. Efeito colateral da flunarizina: parkinsonismo grave. Arq Neuropsiquiatr 1989, 47:352-354.
8. Hefner R, Fischer PA. Zunahme der Parkinson-symptomatik unter Kalzium-antagonisten. Nervenartz 1989, 60:3187-3188.
9. Kuzuhara S, Kohara N, Onkawa Y, Fuse S, Yamanouchi H. Parkinsonism and akathisia induced by flunarizine, a calcium entry blockade: report of 31 cases. Rinsho Shinkeigaku 1989, 29:681-686.
10. Micheli FE, Pardal MF, Gatto M, Torres M, Paradiso G, Parera IC, Giannaula R. Flunarizine and cinarizine induced extrapyramidal reactions. Neurology 1987, 37:881-884.
11. Micheli FE, Pardal MM, Giannaula R, Gatto M, Parera I, Paradiso G, Torres M, Pikielny R, Pardal J. Movement disorders and depression due to flunarizine and cinarizine. Mov Disord 1989, 4:139-146.
12. Ogawa N, Asanuma M, Takayama H, Sato H, Nukina I. Effect of flunarizine hidrochlo-ride on striatal D-2 dopamine receptors. Rinsho Shinkeigaku 1990, 30:1221-1226.
13. Pereira JS, Bertolucci HP, Ferraz HB, Andrade LAF. A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats. Arq Neuropsiquiatr 1992, 50:263-268.
14. Petri H, Leufkens H, Naus J, Silkens R, van Hessen P, Urquhart R. Rapid method for estimating the risk of acutely controversial side effects of prescription drugs. J Clin Epidemiol 1990, 43:433-439.
15. Ross RT. Drug-induced parkinsonism and other movement disorders. Can J Neurol Sci 1990, 17:155-162.
16. Sá PND, Heinisch LMM. Parkinsonismo induzido pela flunarizina. Arq Neurospsiquiatr 1989, 47:471-473.
17. Tipton KF. Biochemical aspects of drug-induced Parkinson's disease. Bioch Soc Trans 1990, 18:129-131.
18. Wilson JA, MacLennam WJ. Drug induced parkinsonism in elderly patients. Age and Ageing 1989, 18:208-210.

Datas de Publicação

Publicação nesta coleção
19 Jan 2011
Data do Fascículo
Nov 1993

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Bamrach JS, Soni SD. Drug induced Parkinson's disease. Lancet 1987, 2:1031.

[2] 2. Benvenutti F, Baroni A, Bandinelli S, Ferrucci L, Corradetti R, Pantaleo T. Flunarizine-induced parkinsonism in the elderly. J Clin Pharmacol 1988, 28:600-608.

[3] 3. Bezerra JMP, Andrade LAF, Ferraz HB, Arouca EM, Gonçalves SA, Borges V, Mendes MF. Síndrome parkinsoniana induzida pela flunarizina e cinarizina. Arq Neuropsiquiatr 1988, 46(Supl): 348.

[4] 4. Calne DB, Langston JW. Aetiology of Parkinson's disease. Lancet 1983, 2:1457.

[5] 5. Capela D, Laport JR, Caste JM, Tristan C, Cos A, Olivas FJM. Parkinsonism, tremor and depression induced by flunarizine. Br Med J 1988, 297.

[6] 6. Chouza C, Scaramelli A, Caamano JL, De Medina O, Romero S, Aljanati R. Parkinsonism, tardive dyskinesia, akathisia and depression induced by flunarizine. Lancet 1986, 1303-1304.

[7] 7. Fontanari JL. Efeito colateral da flunarizina: parkinsonismo grave. Arq Neuropsiquiatr 1989, 47:352-354.

[8] 8. Hefner R, Fischer PA. Zunahme der Parkinson-symptomatik unter Kalzium-antagonisten. Nervenartz 1989, 60:3187-3188.

[9] 9. Kuzuhara S, Kohara N, Onkawa Y, Fuse S, Yamanouchi H. Parkinsonism and akathisia induced by flunarizine, a calcium entry blockade: report of 31 cases. Rinsho Shinkeigaku 1989, 29:681-686.

[10] 10. Micheli FE, Pardal MF, Gatto M, Torres M, Paradiso G, Parera IC, Giannaula R. Flunarizine and cinarizine induced extrapyramidal reactions. Neurology 1987, 37:881-884.

[11] 11. Micheli FE, Pardal MM, Giannaula R, Gatto M, Parera I, Paradiso G, Torres M, Pikielny R, Pardal J. Movement disorders and depression due to flunarizine and cinarizine. Mov Disord 1989, 4:139-146.

[12] 12. Ogawa N, Asanuma M, Takayama H, Sato H, Nukina I. Effect of flunarizine hidrochlo-ride on striatal D-2 dopamine receptors. Rinsho Shinkeigaku 1990, 30:1221-1226.

[13] 13. Pereira JS, Bertolucci HP, Ferraz HB, Andrade LAF. A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats. Arq Neuropsiquiatr 1992, 50:263-268.

[14] 14. Petri H, Leufkens H, Naus J, Silkens R, van Hessen P, Urquhart R. Rapid method for estimating the risk of acutely controversial side effects of prescription drugs. J Clin Epidemiol 1990, 43:433-439.

[15] 15. Ross RT. Drug-induced parkinsonism and other movement disorders. Can J Neurol Sci 1990, 17:155-162.

[16] 16. Sá PND, Heinisch LMM. Parkinsonismo induzido pela flunarizina. Arq Neurospsiquiatr 1989, 47:471-473.

[17] 17. Tipton KF. Biochemical aspects of drug-induced Parkinson's disease. Bioch Soc Trans 1990, 18:129-131.

[18] 18. Wilson JA, MacLennam WJ. Drug induced parkinsonism in elderly patients. Age and Ageing 1989, 18:208-210.