Results of surgical treatment of nonunion of humeral shaft fracture with dynamic compression plate and cancellous bone grafting

Abstracts

OBJETIVO: Avaliamos o tratamento da pseudoartrose de fratura diafisária do úmero com placa de compressão dinâmica de janeiro de 2002 a dezembro de 2009. MÉTODOS: Vinte e dois pacientes foram tratados durante o período do estudo. O trauma foi a causa predominante de lesão em 86,4% dos pacientes. RESULTADOS: A pseudoartrose foi atrófica em 81,8% e hipertrófica em 18,2% dos indivíduos. Havia lesão primária do nervo radial nervo em 27,3% dos pacientes. Todos os participantes tinham fratura fechada à apresentação e 81,2% deles tinham recebido tratamento anterior de traditional bone setters (pessoa que faz a redução de ossos quebrados ou deslocados, geralmente sem ser médico licenciado) e 18,8% tinham falha do tratamento conservador com gesso. O tempo médio até a união foi 16 semanas. O tratamento anterior com traditional bone setters afetou significantemente o tempo de consolidação da fratura (p < 0,05). Todas as fraturas tiveram consolidação bem-sucedida. CONCLUSÃO: Concluímos que o uso de placa de compressão dinâmica continua a ser uma opção eficaz de tratamento da pseudoartrose de fratura diafisária do úmero. Nível de evidência III, Estudo retrospectivo.

Fraturas do úmero; Fraturas do úmero; Regeneração óssea; Fixação de fratura, interna

ORIGINAL ARTICLE

Olasinde Anthony Ayotunde^I; Oluwadiya Kehinde Sunday^II; Adetan Oluwatoyin^I; Ogunlusi Johnson Dare^III

Results of surgical treatment of nonunion of humeral shaft fracture with dynamic compression plate and cancellous bone grafting

^IDepartment of Orthopedic Surgery and Traumatology – Federal Medical Centre, Owo, Ondo State, Nigeria

^IIDepartment of Surgery Ladoke Akintola, University Teaching Hospital, Osogo Osum State Hospital, Nigeria

^IIIRoyal Victoria Hospital Castries, St Lucia, Nigeria

Mailing Address

ABSTRACT

OBJECTIVE: We evaluated the treatment of nonunion of humeral shaft fracture with dynamic compression plate from January 2002 to December 2009.

METHODS: Twenty-two patients were treated over the study period. Trauma was the predominant cause of injury in 86.4% of the patients.

RESULTS: Nonunion was atrophic in 81.8% and hypertrophic in 18.2% of the individuals. There was a primary injury of the radial nerve in 27.3% of the patients. All the participants had closed fracture at presentation, and 81.2% had received previous treatment from traditional bone setters and 18.8% had failure of the conservative cast management. The average time to healing was 16 weeks. Previous treatment from traditional bone setters significantly affected the time to fracture healing (p<0.05). All fractures had successful union.

CONCLUSION: It was concluded that dynamic compression plating remains an effective treatment option for nonunion of humeral shaft fracture. Level of Evidence III, Retrospective study.

Keywords: Humeral fractures/surgery. Humeral fractures/therapy. Bone regeneration. Fracture fixation, internal.

INTRODUCTION

Conservative nonoperative treatment with cast immobilization and bracing provide excellent results in over 90% of cases with union for isolated humeral shaft fractures.^1,2 Nonunion of this fracture is a recognized complication of conservative management. In our environment where patients usually seek traditional bone setters, this remains one of the most common presentations of fractures.³

Varying results had been reported for different types of operative fixation with different associated morbidity relating to each method. The internal fixation methods and their common limitations include unlocked intramedullary nail with poor rotational stability, locked intramedullary nail with associated rotator cuff dysfunction and shoulder movement limitation, external fixation with pin tract infection and dynamic compression plating with wound infection and increased risk of iatrogenic or secondary radial nerve palsy.^1-5 We evaluated the use of dynamic compression plate (DCP) in the operative treatment of patients with nonunion of humeral shaft fractures.

PATIENTS AND METHODS

From January 2002 to December 2009, all the patients who presented humeral shaft fracture nonunion at the orthopedic unit of the Federal Medical Centre Owo, Ondo State, Nigeria, which is a tertiary healthcare institution were reviewed retrospectively. The inclusion criteria are humeral shaft fracture nonunion (which was defined in this study as no evidence of union after a six-month period), no previous surgical intervention, and minimum follow-up of 12 months. The humeral shaft was defined as the part of the humerus that is two centimeters below the surgical neck and 3cm above the olecranon fossa.⁴ Nonunion was classified as defined by Paley et al.⁶ The outcome measure was time to union. Complications were also observed. Plain radiographs were taken to evaluate for union. The surgical approach to the humerus was anterolateral for fractures in upper and middle third and posterior for those in the distal third. The pseudoarthrosis was excised, bone end nibbled until fresh bleeding was obtained and marrow location established; next the bone graft was harvested from iliac crest and used to pack around the bone end. Narrow 4.5mm DCP was used for internal fixation. Successful union was defined as the appearance of bridge callus or bridging of the cortex with at least partial obliteration of the fracture site observed on antero-posterior and lateral radiographs.³ Demographic characteristics of the patients such as age, sex, site, fracture location and description, cause of fracture, previous treatment, and primary radial nerve palsy were recorded.

The results were analyzed using Statistical Package for Social Science version 15. The association test was done using Chi square and the level of significance was p<0.05

RESULTS

Twenty-two patients with humeral fracture nonunion were treated, representing 25.3% of all patients with humeral fractures seen in our hospital over the study period. The median age was 41.5 years with range of 23 to 76 years and male to female ratio of 1.8:1. The cause of injury was road traffic injury in 86.4% (19/22), fall 9.1% (2/22), and assault in 4.5% (1/22). The previous treatment was from traditional bone setters in 81.8% (18/22) patients and failed conservative treatment from other hospital in 18.2% (4/22). Atrophic nonunion occurred in 81.8% (18/22) and hypertrophic nonunion in 18.2 %(4/22) of the individuals (3/22). Only 7.2% (6/22) had primary radial nerve injury. All fractures were closed. The complications were wound hematoma in one patient and superficial wound infection also in one patient. The superficial wound infection resolved with daily wound dressing and antibiotics administration and spontaneous resolution of the hematoma occurred without the need for surgical drainage. The fracture characteristics and surgical approach are as in Table 1.

The average time to union was 16 weeks. Those with previous treatment from traditional bone setters had time to union of 20 weeks, with a time of 12 weeks for those with failed conservative treatment. This was statistically significant at p<0.05. (Table 2) The treatment by the traditional bone setter significantly affected the time to union after open reduction and internal fixation with narrow 4.5 mm dynamic compression plate. We followed the patients at two-week intervals in the first month and then every month for six months and once every two months for another six months.

DISCUSSION

The treatment of nonunion humeral shaft fracture continues to pose a challenge to orthopedic surgeons especially in developing countries where recent advances in the care of this fracture may not be readily available. There has been documented evidence of the superiority of plating of humeral shaft nonunion as reported by Kontakis and associates in their systematic review of literature.⁷

In this study the most common cause of injury was road traffic accident with male preponderance. This was not surprising since trauma has been described as an emerging epidemic in developing countries with the increasing use of automobiles.⁸

It was also observed that more than 80% of the patients in this study had previous treatment with traditional bone setters. The traditional bone setters are alternative practitioners involved in the care of fractures. Their mode of treatment of fractures includes among others the use of local splints made from raffia palms and bamboo sticks. These splints are usually too tight, jeopardizing the blood supply to the affected limb which may result in gangrene from compartment syndrome.⁹ Previous studies had shown several reasons for the patients' continued preference for alternative practitioners, and they only seek medical treatment when complications occur.¹⁰

The distribution of humeral fracture nonunion was predominantly of the atrophic type in more than 80% of the patients in this study. This was similar to the report by Tannura et al. in Brazil, where 15 of the 16 patients who had plate osteosynthesis for humeral nonunion had the atrophic type.¹¹

Primary radial nerve palsy occurred in 27% of the patients in this study with 18% associated with fractures in the middle third of the humeral shaft. This finding was similar to the report by Tsai et al.¹² This is probably due to the closeness of the proximal part of the radial nerve to the bone (in the radial groove) in this part of the humerus, making it vulnerable to injury.

Transverse fracture pattern was the most common associated with humeral shaft nonunion in this study. This contrasted with the report by Ring and associates who found that oblique or spiral fracture with butterfly fragment were the most commonly associated with nonunion of humeral shaft. They also found that nonunion was more common in proximal and middle third shaft fractures. This was consistent with our study where the predominant fracture site was in the middle third.¹³

The average time to union of all the fractures after plate osteosynthesis was 16 weeks. This was also consistent with the reports by other authors.^9,14,15

Patients who had previous treatment with traditional bone setters had a time to union of 20 weeks and those without had 12 weeks. This was statistically significant. This difference may be due to the manner of application of the splint which is often too tight leading to progressive diminution of the blood supply to the affected limb. The reason for the inappropriate application of the splint is the lack of knowledge of anatomy of traditional bone setters. Other authors have documented the different complications associated with this splint.^{16, 17}

One of the banes of plate osteosynthesis is infection. This ranged from 1-5%¹⁸ except in the report by Changulani where it was as high as 20%.⁵

Superficial infection occurred in 4.5% of the patients in this study and was resolved with antibiotics.

CONCLUSION

In conclusion plate osteosynthesis of humeral fracture nonunion achieved successful union in all our patients.

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Publication Dates

• Publication in this collection
  01 Aug 2012
• Date of issue
  2012

History

• Received
  27 May 2010
• Accepted
  24 Oct 2010