In the present study the target population has been leprosy patients submitted to multidrug therapy at a regional health specialities out patient service. The actions and difficulties that ocurred during the experience of this new therapeutic scheme, have been analysed from the patients and also from the various professionals point of view. It has been verified that 68,5% of the patients believed in the treatment, and 89,5% reported to feel more secure with this new therapeutic scheme, 44,6% of the interviewed patients quoted financial and transportation problems to follow treatment. Among the professionals, 88,4% assert that multidrug therapy contributed to promote a better control of disease and their greatest difficulty was concentrated in organizational problems (50,0%); 83,3% believed in the treatment, and 33,4% didn't believe in the cure of the disease.