Relationship between diagnostic characteristics, lifestyle habits and breast cancer subtypes in women<sup/>

Marin, Fernanda Cristina; Sousa, Clóvis Arlindo de; Abuchaim, Erika de Sá Vieira; Silva, Isília Aparecida

doi:10.1590/1518-8345.7492.4581

person Fernanda Cristina Marin

Substantial contributions to the conception or design of the work · or the acquisition, analysis, or interpretation of data for the work · drafting the work or reviewing it critically for important intellectual content · final approval of the version to be published and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

schoolUniversidade de São Paulo, Escola de Enfermagem, São Paulo, SP, Brazil.

0009-0004-9173-3898

person Clóvis Arlindo de Sousa

Substantial contributions to the conception or design of the work · or the acquisition, analysis, or interpretation of data for the work · drafting the work or reviewing it critically for important intellectual content · final approval of the version to be published and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

schoolUniversidade Regional de Blumenau, Departamento de Educação Física e Desportos, Blumenau, SC, Brazil.

0000-0001-5049-5345

person Erika de Sá Vieira Abuchaim

Substantial contributions to the conception or design of the work · or the acquisition, analysis, or interpretation of data for the work · drafting the work or reviewing it critically for important intellectual content · final approval of the version to be published and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

schoolUniversidade Federal de São Paulo, Escola Paulista de Enfermagem, São Paulo, SP, Brazil.

0000-0002-1881-4016

person Isília Aparecida Silva

Substantial contributions to the conception or design of the work · or the acquisition, analysis, or interpretation of data for the work · drafting the work or reviewing it critically for important intellectual content · final approval of the version to be published and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

schoolUniversidade de São Paulo, Escola de Enfermagem, São Paulo, SP, Brazil.

0000-0001-5534-9996

personCorresponding author: Fernanda Cristina Marin E-mail:
fernanda.marin@usp.br

Conflict of interest:

the authors have declared that there is no conflict of interest.

Associate Editor:

Ricardo Alexandre Arcêncio

Age at diagnosis (years)	Histological subtype				Total n=323	p-value
Age at diagnosis (years)		Ductal carcinoma	Lobular carcinoma	Others	Total n=323	p-value
<40	n	73	3	2	78	0.253*
	%	93.6	3.8	2.6	100.0
	Residual	1.8	-1.7	-0.6
40 - 59	n	178	19	9	206	0.253*
	%	86.4	9.2	4.4	100.0
	Residual	-0.9	0.5	0.8
60+	n	32	6	1	39	0.253*
	%	82.1	15.4	2.6	100.0
	Residual	-1.1	1.6	-0.4
BMI ^†					n=323
<25.0	n	95	10	5	110	0.652*
	%	86.4	9.1	4.5	100.0
	Residual	-0.5	0.2	0.6
25.0 - 29.9	n	113	8	5	126	0.652*
	%	89.7	6.3	4.0	100.0
	Residual	0.9	-1.2	0.2
>=30	n	75	10	2	87	0.652*
	%	86.2	11.5	2.3	100.0
	Residual	-0.5	1.1	-0.8
Total family members with breast cancer					n=323
0	n	172	18	9	199	0.609*
	%	86.4	9.0	4.5	100.0
	Residual	-0.8	0.3	1
1	n	73	5	3	81	0.609*
	%	90.1	6.2	3.7	100.0
	Residual	0.8	-0.9	0
2+	n	38	5	0	43	0.609*
	%	88.4	11.6	0.0	100.0
	Residual	0.2	0.7	-1.4

		Histological subtype			Total	p-value
		Ductal carcinoma	Lobular carcinoma	Others	Total	p-value
Alcohol consumption					n=323
No	n	261	26	10	297	0.454*
	%	87.9	8.8	3.4	100.0
	Residual	0.5	0.2	-1.1
Yes	n	22	2	2	26	0.454*
	%	84.6	7.7	7.7	100.0
	Residual	-0.5	-0.2	1.1
Smoking					n=323
Never	n	172	16	10	198	0.554*
	%	86.9	8.1	5.1	100.0
	Residual	-0.5	-0.5	1.6
Ex-smoker	n	75	7	1	83	0.554*
	%	90.4	8.4	1.2	100.0
	Residual	0.9	-0.1	-1.4
Smoker	n	36	5	1	42	0.554*
	%	85.7	11.9	2.4	100.0
	Residual	-0.4	0.8	-0.5
Smoking time (years)					n=125
1 - 9	n	28	3	1	32	0.648*
	%	87.5	9.4	3.1	100.0
	Residual	-0.3	-0.1	0.8
10 - 19	n	26	1	0	27	0.648*
	%	96.3	3.7	0.0	100.0
	Residual	1.4	-1.2	-0.7
20 or more	n	57	8	1	66	0.648*
	%	86.4	12.1	1.5	100.0
	Residual	-0.9	1	-0.1
Physical activity (minutes per week)					n=323
Insufficiently active (<150)	n	104	11	5	281	1.000*
	%	86.7	9.2	4.2	100.0
	Residual	-0.6	0.4	0.5
Sufficiently active (>=150)	n	38	3	1	42	1.000*
	%	90.5	7.1	2.4	100.0
	Residual	0.6	-0.4	-0.5
Predominant type of diet throughout life
Processed foods (daily intake)					n=323
No	n	40	6	6	52	0.003
	%	76.9	11.5	11.5	100.0
	Residual	-2.6	0.8	3.3
Yes	n	243	22	6	271	0.003
	%	89.7	8.1	2.2	100.0
	Residual	2.6	-0.8	-3.3
Sugar (daily intake)					n=323
No	n	62	8	3	73	0.694*
	%	84.9	11.0	4.1	100.0
	Residual	-0.8	0.8	0.2
Yes	n	221	20	9	250	0.694*
	%	88.4	8.0	3.6	100.0
	Residual	0.8	-0.8	-0.2
Dairy products (daily intake)					n=323
No	n	67	7	3	77	0.952*
	%	87.0	9.1	3.9	100.0
	Residual	-0.2	0.2	0.1
Yes	n	216	21	9	246	0.952*
	%	87.8	8.5	3.7	100.0
	Residual	0.2	-0.2	-0.1
Vegetables and fruit (daily intake)					n=323
No	n	30	3	0	33	0.752*
	%	90.9	9.1	0.0	100.0
	Residual	0.6	0.1	-1.2
Yes	n	253	25	12	290	0.752*
	%	87.2	8.6	4.1	100.0
	Residual	-0.6	-0.1	1.2
Soft drinks or artificial juice (weekly frequency)					n=322*
0	n	103	15	8	126	0.044
	%	81.7	11.9	6.3	100.0
	Residual	-2.5	1.6	2
1 - 2	n	89	8	0	97	0.044
	%	91.8	8.2	0.0	100.0
	Residual	1.5	-0.2	-2.3
3+	n	90	5	4	99	0.044
	%	90.9	5.1	4.0	100.0
	Residual	1.2	-1.5	0.2

		Molecular subtype*				Total	p-value
		Luminal A	Luminal B	HER 2+	Triple negative	Total	p-value
Age at diagnosis (years)						n=317
<40	n	13	29	16	20	78	0.006
	%	16.7	37.2	20.5	25.6	100.0
	Residual	-1.7	-1.3	0.9	2.8
40 - 59	n	46	94	34	28	202	0.006
	%	22.8	46.5	16.8	13.9	100.0
	Residual	-0.5	1.4	-0.1	-1.2
60+	n	16	15	4	2	37	0.006
	%	43.2	40.5	10.8	5.4	100.0
	Residual	3	-0.4	-1.1	-1.8
BMI ^†						n=317
<25.0	n	27	48	14	17	106	0.389 ^‡
	%	25.5	45.3	13.2	16.0	100.0
	Residual	0.5	0.4	-1.3	0.1
25.0 - 29,9	n	32	49	27	16	124	0.389 ^‡
	%	25.8	39.5	21.8	12.9	100.0
	Residual	0.7	-1.2	1.8	-1.1
>=30	n	16	41	13	17	87	0.389 ^‡
	%	18.4	47.1	14.9	19.5	100.0
	Residual	-1.4	0.8	-0.6	1.1
Family members with breast cancer						n=317
0	n	41	84	35	36	196	0.048 ^‡
	%	20.9	42.9	17.9	18.4	100.0
	Residual	-1.5	-0.3	0.5	1.6
1	n	22	39	13	4	78	0.048 ^‡
	%	28.2	50.0	16.7	5.1	100.0
	Residual	1.1	1.3	-0.1	-3
2+	n	12	15	6	10	43	0.048 ^‡
	%	27.9	34.9	14.0	23.3	100.0
	Residual	0.7	-1.2	-0.6	1.4

		Molecular subtype*				Total	p-value
		Luminal A	Luminal B	HER 2+	Triple negative	n=317
Alcohol consumption
No	n	66	127	53	46	292	0.189 ^†
	%	22.6	43.5	18.2	15.8	100.0
	Residual	-1.5	0	1.8	0
Yes	n	9	11	1	4	25	0.189 ^†
	%	36.0	44.0	4.0	16.0	100.0
	Residual	1.5	0	-1.8	0
Smoking						n=317
Never	n	42	85	33	35	195	0.695 ^†
	%	21.5	43.6	16.9	17.9	100.0
	Residual	-1.1	0	-0.1	1.3
Ex-smoker	n	22	37	14	8	81	0.695 ^†
	%	27.2	45.7	17.3	9.9	100.0
	Residual	0.9	0.5	0.1	-1.7
Smoker	n	11	16	7	7	41	0.695 ^†
	%	26.8	39	17.1	17.1	100.0
	Residual	0.5	-0.6	0	0.2
Smoking time (years)						n=122
1 - 9	n	6	20	3	3	32	0.290 ^†
	%	18.8	62.5	9.4	9.4	100.0
	Residual	-1.2	2.5	-1.4	-0.6
10 - 19	n	7	11	4	4	26	0.290 ^†
	%	26.9	42.3	15.4	15.4	100.0
	Residual	0	-0.1	-0.3	0.5
20 or more	n	20	22	14	8	64	0.290 ^†
	%	31.3	34.4	21.9	12.5	100.0
	Residual	1.1	-2.1	1.4	0.1
Physical activity (minutes per week)						n=317
Insufficiently active (<150)	n	65	118	48	46	277	0.646 ^†
	%	28.8	40.7	13.6	16.9	100.0
	Residual	0.5	-1	-0.2	1.1
Sufficiently active (>=150)	n	10	20	6	4	40	0.646 ^†
	%	25	50	15	10	100.0
	Residual	-0.5	1	0.2	-1.1
Predominant type of diet throughout life
Processed foods (daily intake)						n=317
No	n	13	23	8	8	52	0.992 ^†
	%	25	44.2	15.4	15.4	100.0
	Residual	0.2	0.1	-0.3	-0.1
Yes	n	62	115	46	42	265	0.992 ^†
	%	23.4	43.4	17.4	15.8	100.0
	Residual	-0.2	-0.1	0.3	0.1
Sugar (daily intake)						n=317
No	n	22	33	6	9	70	0.072 ^†
	%	31.4	47.1	8.6	12.9	100.0
	Residual	1.7	0.7	-2.1	-0.8
Yes	n	53	105	48	41	247	0.072 ^†
	%	21.5	42.5	19.4	16.6	100.0
	Residual	-1.7	-0.7	2.1	0.8
Dairy products (daily intake)						n=317
No	n	18	35	10	14	77	0.690 ^†
	%	23.4	45.5	13.0	18.2	100.0
	Residual	-0.1	0.4	-1.1	0.7	-0.1
Yes	n	57	103	44	36	240	0.690 ^†
	%	23.8	42.9	18.3	15.0	100.0
	Residual	0.1	-0.4	1.1	-0.7
Vegetables and fruit (daily intake)						n=317
No	n	6	13	7	7	33	0.607 ^†
	%	18.2	39.4	21.2	21.2	100.0
	Residual	-0.8	-0.5	0.7	0.9
Yes	n	69	125	47	43	284	0.607 ^†
	%	24.3	44.0	16.5	15.1	100.0
	Residual	0.8	0.5	-0.7	-0.9
Soft drinks or artificial juice (weekly frequency)						n=316 ^‡
0	n	36	53	16	19	124	0.451 ^†
	%	29.0	42.7	12.9	15.3	100.0
	Residual	1.8	-0.3	-1.5	-0.2	93
1 a 2	n	17	40	21	15	100.0	0.451 ^†
	%	18.3	43.0	22.6	16.1
	Residual	-1.5	-0.2	1.8	0.1	99
3+	n	22	45	16	16	100.0	0.451 ^†
	%	22.2	45.5	16.2	16.2
	Residual	-0.4	0.4	-0.2	0.1

[1] *Fisher’s Exact Test; ^†BMI = Body mass index

Relationship between diagnostic characteristics, lifestyle habits and breast cancer subtypes in women^*

Highlights:

Relationship between diagnostic characteristics, lifestyle habits and breast cancer subtypes in women*

Highlights:

Relationship between diagnostic characteristics, lifestyle habits and breast cancer subtypes in women^*