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Peripheral biomarkers of oxidative stress in aging and Alzheimer's disease

Biomarcadores periféricos do estresse oxidativo no envelhecimento e na doença de Alzheimer

Abstract

Aging is associated with a greatly increased incidence of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). These conditions are associated with chronic inflammation, which generates oxygen reactive species, ultimately responsible for a process known as oxidative stress. It is well established that this process is the culprit of neurodegeneration, and there are also mounting evidences that it is not restricted to the central nervous system. Indeed, several studies, including some by our group, have demonstrated that increased peripheral oxidative stress markers are associated to aging and, more specifically, to AD. Therefore, it is very instigating to regard aging and AD as systemic conditions that might be determined by studying peripheral markers of oxidative stress.

Key words:
Alzheimer's disease; aging; oxidative stress; peripheral markers

Resumo

O envelhecimento está associado a uma alta incidência de doenças neurodegenerativas, incluindo doença de Alzheimer (DA), doença de Parkinson (DP) e esclerose lateral amiotrófica (ELA). Estas condições estão relacionadas à inflamação crônica que gera espécies reativas de oxigênio, responsáveis por um processo denominado de estresse oxidativo. Está bem estabelecido que este processo está envolvido na neurodegeneração, e existem várias evidências de que ele não é restrito ao sistema nervoso central. De fato, muitos estudos, inclusive alguns de nosso grupo, demonstraram que o aumento de marcadores do estresse oxidativo periférico está associado ao envelhecimento e, mais intensamente, à DA. Assim, é muito instigante pensar no envelhecimento e na DA como doenças sistêmicas que possam ser investigadas por meio de marcadores periféricos de estresse oxidativo.

Palavras-chave:
doença de Alzheimer; envelhecimento; estresse oxidativo; marcadores periféricos

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Acknowledgements

The authors thank Fernando Kok for his helpful comments. CS is supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); EMK, by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and LRS by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Work in the laboratory of the authors was supported by FAPESP.

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Publication Dates

  • Publication in this collection
    Jan-Mar 2008

History

  • Received
    24 Jan 2008
  • Reviewed
    14 Feb 2008
  • Accepted
    14 Feb 2008
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices, Torre Norte, São Paulo, SP, Brazil, CEP 04101-000, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br