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vol.52 issue9Laboratory diagnosis of late-onset male hypogonadism andropauseBone and heart abnormalities of subclinical hyperthyroidism in women below the age of 65 years author indexsubject indexarticles search
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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


CLAPAUCH, Ruth et al. Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: usefulness of screening questionnaires. Arq Bras Endocrinol Metab [online]. 2008, vol.52, n.9, pp.1439-1447. ISSN 1677-9487.

OBJECTIVE: To analyze the relative risk of late-onset hypogonadism in men with osteoporosis and the usefulness of screening questionnaires. METHODS: We correlated the Aging Male's Symptoms (AMS), Androgen Deficiency in Aging Male (ADAM) and International Index of Erectile Function (IIEF-5) questionnaires and the laboratory diagnosis of hypogonadism in 216 men aged 50-84 years (110 with osteoporosis and 106 with normal bone density, paired by age and ethnicity). RESULTS: Hypogonadism presented in 25% of the osteoporotic and in 12.2 % of normal bone density men (OR 2.08; IC95%: 1.14-3.79) and was associated with ADAM first question (low libido, p=0.013). Levels of TT below 400 ng/dl correlated with an AMS score above 26 (p=0.0278). IIEF-5 showed no correlation with testosterone levels. CONCLUSION: Hypogonadism was 2.08 times more prevalent in osteoporotic men. The symptom that best correlated with late-onset hypogonadism was low libido (ADAM 1 positive).

Keywords : Andropause; Screening questionnaires; Testosterone; Late-onset hypogonadism; Male osteoporosis.

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