SciELO - Scientific Electronic Library Online

vol.53 issue6Macrovascular diabetic complications: clinical characteristics, diagnosis and managementSearch of prostatic tissue in 46,XX congenital adrenal hyperplasia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


MIRANDA, Elizabete Rosária de; DE MARCO, Luiz  and  SOARES, Maria Marta Sarquis. Splicing variants impact in thyroid normal physiology and pathological conditions. Arq Bras Endocrinol Metab [online]. 2009, vol.53, n.6, pp.709-715. ISSN 1677-9487.

RNA splicing is an essential, precisely regulated process that occurs after gene transcription and before mRNA translation, in which introns may be removed and exons, retained. Variability in splicing patterns is a major source of protein diversity from the genome and function to generate a tremendously diverse proteome from a relatively small number of genes. Changes in splice site choice can determine different effects on the encoded protein. Small changes in peptide sequence can alter ligand binding, enzymatic activity, allosteric regulation, or protein localization. Errors in splicing regulation have been implicated in a number of different disease states. This study reviewed the mechanisms of splicing and their repercussion in endocrinology, emphasizing its importance in some thyroid physiological and pathological conditions.

Keywords : Splicing; thyroid gland; TSH; TPO; thyroid hormone receptor; TGFbeta.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License