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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

MELO, Ailton; RODRIGUES, Bernardo  and  BAR-OR, Amit. Beta interferons in clinically isolated syndromes: a meta-analysis. Arq. Neuro-Psiquiatr. [online]. 2008, vol.66, n.1, pp.8-10. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2008000100003.

Beta-interferon use in definite multiple sclerosis (MS) has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. After two years of follow-up, interferon beta decreased the risk of conversion to clinically definite MS 0.51[0.39-0.65], and delayed the time to diagnosis up to 367 days. Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.

Keywords : interferon; clinically isolated syndromes; multiple sclerosis; immunomodulating therapy.

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