Arquivos de Neuro-Psiquiatria
On-line version ISSN 1678-4227
RODRIGUES, Raimundo Nonato Delgado et al. Evolution of non-treated restless legs syndrome. Arq. Neuro-Psiquiatr. [online]. 2009, vol.67, n.1, pp. 16-20. ISSN 1678-4227. http://dx.doi.org/10.1590/S0004-282X2009000100005.
PURPOSE: The primary concern of this study is to evaluate the clinical course of restless legs syndrome (RLS) in a group of patients who refused treatment. METHOD: This study compares the outcome of a group of RLS patients after one year without any specific treatment. The International Restless Legs Syndrome Scale (IRLS) was applied at baseline (irls_1) and after one year (irls_2). The patients answered a simple questionnaire for the evaluation of possible environmental or life habit changes after one-year evolution. Serum ferritin was determined at baseline. An improvement index (%improvement) was established through the formula: irls_1- irls_2/irls_1 ' 100. Results were compared and a correlation analysis performed. RESULTS: A negative significant correlation was found between the patientsí age and irls_2 (r= -0.9 p=0.0018) and between %improvement and irls_2 (r= -0.88 p=0.0039). A positive and significant correlation was determined between %improvement and age. There was only a marginally significant correlation between serum ferritin and ilrs_2 (r= -0.7 p=0.052). No significant changes were found in the other elements analyzed. CONCLUSION: A favorable outcome was found in this group of RLS patients after one year evolution without treatment. The outcome was positively influenced by the patientsí age.
Keywords : restless legs syndrome; IRLS; outcome; clinical course; long-term evolution; treatment; age.