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Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282XOn-line version ISSN 1678-4227
RODRIGUES, David Henrique; SACHS, Daniela and TEIXEIRA, Antonio Lucio. Mechanical hypernociception in experimental autoimmune encephalomyelitis. Arq. Neuro-Psiquiatr. [online]. 2009, vol.67, n.1, pp.78-81. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X2009000100019.
BACKGROUND: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. OBJECTIVE: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. METHOD: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the von Frey filaments method. A clinical scale ranging from 0 to 15 was used to assess motor impairment. RESULTS: Clinical evidence of disease started at day 10 and peaked at day 14 after immunization. Thereafter, there was no worsening of symptoms until day 26. The EAE-induced mice presented reduced pressure threshold at days 7th and 10th after immunization and before the onset of clinical motor signs. CONCLUSION : The hypernociception found validates MOG35-55 EAE as a model for the study of pain in multiple sclerosis.
Keywords : multiple sclerosis; experimental autoimmune encephalomyelitis; hyperalgesia; mechanical hypernociception.