SOD1 (Superoxide dismutase 1; 21q22.11) – 1993
|
AD/AR |
ALS1 |
C9orf72 (Chromosome 9 Open Reading Frame 72; 9p21.2) – 2011
|
AD |
FTD-ALS type 1, FTD, ALS, HD-like, atypical parkinsonism (PSP-like, CBD-like, MSA-like), CJD-like, AZD-like |
FUS (Fused in Sarcoma; 16p11.2) – 2009
|
AD/AR |
ALS6, Hereditary essential tremor type 4 |
CHMP2B (Chromatin-modifying protein member 2B; 3p11.2) – 2006
|
AD |
ALS17, Chromosome 3-linked FTD |
ALS2 (Alsin; 2q33.1) – 2001
|
AR |
ALS2, Juvenile Primary Lateral Sclerosis, Infantile-onset Ascending Spastic Paralysis |
UBQLN2 (Ubiquilin 2; Xp11.21) – 2011
|
XD |
ALS15 |
PFN1 (Profilin 1; 17p13.2) – 2012
|
AD |
ALS18 |
OPTN (Optineurin; 10p13) – 2009/2010
|
AR/AD |
ALS12, primary open angle glaucoma type 1, Paget disease of bone |
TARDBP (TAR DNA-binding protein; 1p36.22) – 2008
|
AD |
ALS10, FTD |
SQSTM1 (Sequestosome 1; 5q35.3) – 2011
|
AD |
ALS, Paget disease of bone |
PRPH (Peripherin; 12q13.12) – 2004
|
AD? |
ALS |
HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1; 12q13.13) – 2013
|
AD |
ALS20, IBM with early-onset Paget disease without FTD type 3 |
DCTN1 (Dynactin 1; 2p13.1) – 2003
|
AD |
ALS, Perry syndrome, Distal hereditary motor neuronopathy with vocal paresis (type VIIB) |
ANG (Angiogenin; 14q11.2) – 2006
|
AD |
ALS9 |
FIG4 (FIG4, S. cerevisiae, homolog of SAC1 lipid phosphatase domain containing; 6q21) – 2009
|
AD |
ALS11, Charcot-Marie-Tooth disease type 4J, Yunis-Varon syndrome, Bilateral Temporooccipital Polymicrogyria, Primary Lateral Sclerosis |
NEFH (Neurofilament protein, Heavy Polypeptide; 22q12.2) – 1999
|
AD |
ALS |
VCP (Valosin-containing Protein; 9p13.3) – 2010
|
AD |
ALS14, IBM with early-onset Paget disease and FTD type 1 |
SETX (Senataxin; 9q34.13) – 2004
|
AD |
ALS4, ataxia with oculomotor apraxia type 2 (AOA2) |
ERBB4 (V-Erb-B2 avian erythroblastic leucemia viral oncogene homolog 4; 2q34) – 2013
|
AD |
ALS19, schizophrenia, melanoma |
SIGMAR1 (Sigma Nonopioid Intracellular Receptor 1; 9p13.3) – 2011
|
AR |
ALS16 |
VAPB (Vesicle-associated Membrane Protein-associated Protein B; 20q13.32) – 2004
|
AD |
ALS8, late-onset Spinal Muscular Atrophy Finkel type |
MATR3 (Matrin-3; 5q31.2) – 2014
|
AD |
ALS21 |
CHCHD10 (Coiled-coil-helix-coiled-coil-helix-domain-containing protein 10; 22q11.23) – 2014
|
AD |
FTD-ALS type 2 |
DAO (D-amino acid oxidase; 12q24) – 2010
|
AD |
ALS, Schizophrenia |
ATXN2 (ataxin 2; 12q24.12) – 2010
|
AD |
ALS13, Spinocerebellar ataxia type 2 |
SMN1 (Survival of Motor Neuron 1; 5q13.2) – 2012
|
AD |
ALS, Spinal muscular atrophy (types 1-4) |
EWSR1 (Ewing sarcoma breakpoint region 1; 22q12.2) – 2012
|
AD |
ALS, Ewing sarcoma, Neuroepithelioma |
TAF15 (TAF15 RNA polymerase II, TATA box-binding protein-associated factor, 68-kD; 17q12) – 2011
|
AD |
ALS, Extraskeletal myxoid chondrosarcoma |
SPG11 (SPG11 gene/spatacsin; 15q21.1) – 2010
|
AR |
ALS5, Hereditary Spastic Paraplegia type 11 (SPG11) |
TUBA4A (Tubulin, alpha-4A; 2q35) – 2014
|
AD |
ALS |
TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7; 15q21.2) – 2005
|
AD? |
ALS-Parkinsonism/Dementia complex type 1 |
VEGF (Vascular Endothelial Growth Factor; 6p21.1) |
AD? |
ALS, Microvascular complications of diabetes 1 |