Lambert-Eaton myasthenic syndrome: the 60th anniversary of Eaton and Lambert's pioneering article

Síndrome miastênica de Lambert-Eaton: o 60° aniversário do artigo pioneiro de Eaton e Lambert

ABSTRACT

This historical review describes the contribution of Drs. Lee M. Eaton and Edward H. Lambert to the diagnosis of myasthenic syndrome on the 60^th anniversary of their pioneering article (JAMA 1957) on the disease. There are important landmarks in their article on a disorder of the neuromuscular junction associated with thoracic neoplasm and the electrophysiological criteria for Lambert-Eaton myasthenic syndrome (LEMS). After 60 years, the main electrophysiological criteria described in Eaton and Lambert's pioneering article are still currently useful in the diagnosis of LEMS.

Keywords:
Lambert-Eaton myasthenic syndrome; electromyography; diagnosis