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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
SANTOS, Fernanda Teixeira dos; PINTO, Viviane M. and GRAEFF-TEIXEIRA, Carlos. Evidences against a significant role of Mus musculus as natural host for Angiostrongylus costaricensis. Rev. Inst. Med. trop. S. Paulo [online]. 1996, vol.38, n.3, pp.171-175. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46651996000300002.
Wild rodents have been described as the most important hosts for Angiostrongylus costaricensis in Central America and southern Brazil. Sinantropic rodents apparently do not play a significant role as natural hosts. A search for natural infection failed to document worms in 14 mice captured in the house of a patient with diagnosis of abdominal angiostrongylosis and experimental infection of a "wild" Mus musculus strain and groups of albino Swiss mice were carried out. Mortality was not significantly different and varied from 42% to 80% for Swiss mice and from 26% to 80% for "wild" mice. The high mortality of a "wild" M. musculus infected with A. costaricensis was very similar to what is observed with most laboratory mice strains. These data may be taken as indications that M. musculus is not a well adapted host for A. costaricensis, although susceptibility was apparently higher with "wild" populations of M. musculus as compared to Swiss strain.
Keywords : Angiostrongylus costaricensis; Mus musculus; Angiostrongylosis.