SciELO - Scientific Electronic Library Online

vol.35 issue4Extraction of the dye of beet (Beta vulgaris) for use as indicated in acid-base author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Eclética Química

Print version ISSN 0100-4670


LINDINO, Cleber Antonio et al. Estudo de estabilidade do fosfato dissódico de prednisolona em condições de estresse oxidativo e térmico, em formulação oral. Eclet. Quím. [online]. 2010, vol.35, n.4, pp.9-15. ISSN 0100-4670.

This work was to investigate the process of degradation of the drug Prednisolone Sodium Phosphate (FSP) in oral solution dosage form through the degradation experiments, evaluating the parameters in accordance with Resolution 899/2003 ANVISA and the degradation process of the drug. The method by high performance liquid chromatography (HPLC) developed for the determination of the drug was validated to demonstrate its applicability as an indicator of stability, ensuring reliability. After the method be validated to study the degradation of the drug, it was shown that drastic conditions of oxidative stress (H2O2 30%) and temperature 60 ° C, the degradation of the drug is dependent on its concentration (first order kinetics). The results were satisfactory, showing that this method is suitable to investigate the formation of degradation products in oral dosage form solution.

Keywords : prednisolone sodium phosphate; stability study method; degradation.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License