Revista Brasileira de Farmacognosia
versão impressa ISSN 0102-695X
MOREIRA, R.R.D. et al. Mutagenicity evaluation of crude ethanolic extract of Paepalanthus latipes (Eriocaulaceae) and isolated 7-methoxyflavonoids. Rev. bras. farmacogn. [online]. 2002, vol.12, n.1, pp. 11-19. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2002000100002.
Paepalanthus latipes (Silveira) is one of the native Brazilian plants from Serra do Cipó, Minas Gerais, known as "sempre-vivas" which is exported to the United States, Europe and Japan because of its ornamental value. Few results were reported in relation to the biological activity of these plants. In this work, the mutagenicity of the crude ethanolic extract of P. latipes and isolated 7-methoxyflavonoids (7-methylquercetagetin and 7-methylquercetagetin-4'-O-β-D-glucopyranoside) was evaluated by using the Ames test with Salmonella typhimurium TA98 and TA100 strains, at concentrations from 62.5 to 375 μg/plate, with and without metabolic activation (using microsomal S9 fraction). Results demonstrated that both the extract of P. latipes as well as the tested 7-methoxyflavonoids did not induce mutagenicity at the experimental tested conditions.
Palavras-chave : Mutagenicity; AMES test; Paepalanthus latipes; Eriocaulaceae; flavonoids; Salmonella typhimurium.