Journal of the Brazilian Chemical Society
versão impressa ISSN 0103-5053
GIL, Éric de S.; CORDEIRO, Diogo D.; MATIAS, Ana E. B. e SERRANO, Sílvia H. P.. Electrochemical Behavior and Determination of Fluconazole. J. Braz. Chem. Soc. [online]. 2011, vol.22, n.4, pp. 767-771. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532011000400021.
The electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical - chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the fluconazole concentration, Ipa = 5.7×10-5 (mA) × 0.052 [Fluconazol] (μg mL-1), in the range of 48.0 to 250.0 μg mL-1. The detection limit obtained was 6.3 μg mL-1.
Palavras-chave : fluconazole; electrochemical behavior; voltammetry; electrodic material.