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Journal of the Brazilian Chemical Society

versión impresa ISSN 0103-5053


IBRAHIM, Magdy A.; HASSANIN, Hany M.; GABR, Yassin A.  y  ALNAMER, Youssef A.. Studies on the chemical behavior of 3-(nitroacetyl)-1-ethyl-4-hydroxyquinolin-2(1H)-one towards some electrophilic and nucleophilic reagents. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.5, pp.905-912. ISSN 0103-5053.

A variety of heterocyclic systems linked to 1-ethylquinolin-2(1H)-one was prepared from reaction of 3-(nitroacetyl)-1-ethyl-4-hydroxyquinolin-2(1H)-one with some electrophilic and nucleophilic reagents. Besides its cyclization to 5-ethyl-2-(hydroxyimino)-2,3,4,5-tetrahydrofuro[3,2-c]quinoline-3,4-dione, the 3-(nitroacetyl)-1-ethyl-4-hydroxyquinolin-2(1H)-one has been brominated, chlorinated, formylated, acetylated, and condensed with chromone-3-carbonitrile and 2-amino-3-formylchromone. Some new pyrazolo[4,3-c]quinoline, pyrimido[5,4-c]quinoline and quinolino[4,3-b][1,5]benzodiazepine derivatives were also synthesized.

Palabras clave : β-ketoacid; 3-nitroacetylquinolinone; pyrazolo[4,3-c]quinolinones; pyrimido[5,4-c]quinolinones; cyclocondensation.

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