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Articles • J. Braz. Chem. Soc. 23 (10) • Oct 2012 • https://doi.org/10.1590/S0103-50532012005000053   copy

Synthesis of N-substituted phthalimidoalkyl 1H-1,2,3-triazoles: a molecular diversity combining click chemistry and ultrasound irradiation

Authorship SCIMAGO INSTITUTIONS RANKINGS

A series of 1,2,3-triazole derivatives was synthesized from N-phthalimidoalkyl-azides (A1 -A4) and alkynes (a-e) under ultrasound irradiation in the presence of CuI, Et3N and DMF as solvent. The present protocol afforded 18 new 1,2,3-triazoles (1-4) in good-to-excellent yields (67-98%).

1,2,3-triazole; phthalimide; ultrasound; copper-catalyst; click chemistry

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