SciELO - Scientific Electronic Library Online

 
vol.47 número3Relapsing polychandritis in the childhood: case report and literature review índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

Compartir


Revista Brasileira de Reumatologia

versión impresa ISSN 0482-5004versión On-line ISSN 1809-4570

Resumen

ROSA, Dario Júnior de Freitas et al. Macrophage activation syndrome following the use of Leflunomide in a patient with adult-onset Still disease: case report. Rev. Bras. Reumatol. [online]. 2007, vol.47, n.3, pp.219-222. ISSN 0482-5004.  http://dx.doi.org/10.1590/S0482-50042007000300013.

A 32-year-old white female, with adult-onset Still disease, was admitted following a 15-day course of leflunomide, with persistent fever and a generalized tonic-clonic seizure. She quickly developed liver and spleen enlargement, impairment of liver function, thrombocytopenia, elevation of lactate-dehydrogenase, trylicerides and ferritin, and renal failure, being diagnosed with the macrophage activation syndrome, a rare complication of rheumatic diseases due to activation and uncontrolled proliferation of T lymphocytes and excessive macrophage activation. The syndrome may lead to disseminated intravascular coagulation, renal impairment being a rare event. Pulse therapy with methylprednisolone and cyclosporine are the therapeutic options.

Palabras clave : macrophage activation syndrome; Still disease; leflunomide.

        · resumen en Portugués     · texto en Portugués     · Portugués ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons