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Revista Brasileira de Reumatologia

versión impresa ISSN 0482-5004versión On-line ISSN 1809-4570

Resumen

ROSA, Dario Júnior de Freitas et al. Accelerated nodulosis in rheumatoid arthritis during Leflunomide therapy. Rev. Bras. Reumatol. [online]. 2007, vol.47, n.3, pp.228-231. ISSN 0482-5004.  http://dx.doi.org/10.1590/S0482-50042007000300015.

Accelerated nodulosis is the development of a large number of nodules during a short time in adult patients presenting either seropositive or seronegative rheumatoid arthritis. These nodules are usually described as associated to methotrexate therapy. There have been three case reports of patients who developed peripheral accelerated nodulosis while receiving leflunomide. We describe a 60-years old woman with seropositive rheumatoid arthritis who developed accelerated nodulosis after four months receiving leflunomide therapy. The patient had a complete regression of the subcutaneous nodules eight months after cessation of leflunomide.

Palabras clave : rheumatoid arthritis; accelerated nodulosis; leflunomide.

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