Say27Say F, Gürler D, Yener K, Bülbül M, Malkoç M. Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis. Acta Chir Orthop Traumatol Cech. 2013;80(4):278-83.
|
Prospective Controlled Non-randomized |
Knee |
Single |
45 |
45 HA |
Injection Single |
KOOS VAS |
0, 3 and 6 months |
PRP superior to HA. Better cost-benefit of PRP |
Kon32Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Arthroscopy. 2011;27(11):1490-501.
|
Prospective Controlled Non-randomized |
Knee |
Double |
50 |
50 HAAP 50 LWHA |
3 injections Biweekly |
IKDC EQ-VAS |
2 and 6 months |
PRP showed benefit; Better results in young people and lower degree of degeneration |
Sánchez34Sánchez M, Anitua E, Azofra J, Aguirre JJ, Andia I. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008;26(5):910-3.
|
Retrospective |
Knee |
Single |
30 |
30 HA |
3 injections Weekly |
WOMAC |
8 weeks |
PRP superior to HA |
Kon35Kon E, Filardo G, Buda E, Timoncini A, Di Martino A, Cenacchi A, et al. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc. 2010;18:472-9.
|
Prospective |
Knee |
Double |
100 |
None |
3 injections Every 3 weeks |
IKDC EQ-VAS |
2, 6 and 12 months |
PRP showed benefit; Better results in young people and lower degree of degeneration |
Filardo36Filardo G, Kon E, Buda E, Timoncini A, Di Martino A, Cenacchi A, et al. Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2010;19:528-35.
|
Prospective |
Knee |
Double |
91 |
None |
3 injections Every 3 weeks |
IKDC EQ-VAS |
2, 6, 12 and 24 months |
PRP showed benefit; Decrease in response after 12 months, but higher than the initial scores |
Sampson37Sampson S, Reed M, Silvers H, Meng M, Mandelbaum B. Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study. Am J Phys Med Rehabil. 2010;89(12):961-9.
|
Prospective |
Knee |
Single |
14 |
None |
3 injections Monthly |
Brittberg- Peterson VAS KOOS Thickness |
2, 5, 11, 18 and 52 weeks |
PRP showed benefit; No increase in thickness of cartilage |
Ana Wang-Saegusa38Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cuscó X, Garcia-Balletbó M. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2011;131:311-7.
|
Prospective |
Knee |
Single |
261 |
None |
3 injections Biweekly |
VAS SF-36 WOMAC Lequesne |
6 months |
PRP showed benefit |
Napolitano39Napolitano M, Matera S, Bossio M, Crescibene A, Costabile E, Almolla J, et al. Autologous platelet gel for tissue regeneration in degenerative disorders of the knee. Blood Transfus. 2012;10:72-7.
|
Prospective |
Knee |
Single |
27 |
None |
3 injections Weekly |
WOMAC NRS |
7 days and 6 months |
PRP showed benefit |
Sanchez40Sánchez M, Guadilla J, Fiz N, Andia I. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Rheumatology. 2012;51:144-50.
|
Prospective |
Hip |
Single |
40 |
None |
3 injections Weekly |
WOMAC VAS HHS |
6–7 weeks and 6 months |
PRP showed benefit |
Jang41Jang SJ, Kim JD, Cha SS. Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis. Eur J Orthop Surg Traumatol. 2013;23:573-80.
|
Prospective |
Knee |
Double |
65 |
None |
Injections single |
WOMAC |
1, 3,6 9 and 12 months |
PRP showed benefit |
Battaglia42Battaglia M, Guaraldi F, Vannini F, Buscio TR, Galletti S, Giannini S. Platelet-rich plasma intra-articular ultrasound-guided injections as a possible treatment for hip osteoarthritis: a pilot study. Clin Exp Rheumatol. 2011;29(4):754
|
Prospective Pilot study |
Hip |
Not specified |
20 |
None |
3 injections Biweekly |
HHS WOMAC |
3, 6 and 12 months |
PRP showed benefit; Decrease in response after 3 months, but higher than the initial scores. Better results in young people. |
Halpern43Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, et al. Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clin J Sport Med. 2013;23:238-9.
|
Prospective Pilot Study |
Knee |
Not specified |
17 |
None |
Injections Single |
VAS WOMAC MRI de knee |
1, 3, 6 and 12 months |
PRP showed benefit There was no reduction in cartilage thickness in MRI |
Gobbi44Gobbi A, Karnatzikos G, Mahajan V, Malchira S. Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis: preliminary results in group of active patients. Sports Health. 2012;4:162
|
Prospective |
Knee |
Single |
50 |
None |
2 injections Monthly |
KOOS, VAS Tegner IKDC Marx scores |
0, 6 and 12 months |
PRP showed benefit; There was no difference between patients that were previously approached and patients with no previous intervention. |
Hart45Hart R, Safi A, Komzak M, Jajtner P, Puskeiler M, Hartova P. Platelet-rich plasma in patients with tibiofemoral cartilage degeneration. Arch Orthop Trauma Surg. 2013;133:1295-301.
|
Prospective |
Knee |
Double |
55 |
None |
6 injections Weekly. After maintenance with 3 quarterly injections |
Lysholm Tegner IKDC Cincinnati Knee MRI |
0 and 12 months |
PRP showed benefit There was no reduction in cartilage thickness in MRI |
Filardo46Filardo G, Kon E, Ruiz MTP, Vaccaro F, Guitaldi R, Di Martino A, et al. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single-versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2011;20:2082-91.
|
Prospective |
Knee |
Double |
72 PRGF 72 PRP |
None |
3 injections Each 3 weeks |
IKDC EQ-VAS Tegner scores |
2, 6 and 12 months |
Similar benefit between methods; Double centrifugation shows more side effects |
Dhollander47Dhollander AAM, De Neve F, Almqvist KF, Verdonk R, Lambrecht S, Elewaut D, et al. Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. Knee Surg Sports Traumatol Arthrosc. 2011;19:536-42.
|
Prospective |
Knee |
Double |
5 |
None |
Injections Single |
VAS KOOS Tegner Score MOCART |
0, 12 and 24 months |
Procedure leads to clinical improvement; No response in the analysis of cartilage in MRI |