Selvaggi1919. Selvaggi SM. Reporting of atypical squamous cells, cannot
exclude a high-grade squamous intraepithelial lesion (ASC-H) on cervical
samples: is it significant? Diagn Cytopathol. 2003;29(1):38-41.
|
22 |
15 women (68%) |
Louro et al.1818. Louro AP, Roberson J, Eltoum I, Chhieng DC. Atypical squamous
cells, cannot exclude high-grade squamous intraepithelial lesion. A follow-up
study of conventional and liquid-based preparations in a high-risk population.
Am J Clin Pathol. 2003;120(3):392-7.
|
Pap test preparation types with ASC-H: 190
conventional smear 28 liquid-based preparation (ThinPrep) |
Prevalence of CIN II+ according to Pap test
preparation type: Liquid-based preparations = 9 (45%)
Conventional smears = 70 (46.1%) There was no statistically
significant difference in the incidence of CIN II or higher on
subsequent biopsies after interpretation of ASC-H based on the
preparation type |
Duncan and Jacob2222. Duncan LD, Jacob SV. Atypical squamous cells, cannot exclude a
high-grade squamous intraepithelial lesion: the practice experience of a
hospital-based reference laboratory with this new Bethesda system diagnostic
category. Diagn Cytopathol. 2005;32(4):243-6.
|
99 |
40 women (40.4%) |
Barreth et al.1717. Barreth D, Schepansky A, Capstick V, et al. Atypical squamous
cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a
result not to be ignored. J Obstet Gynaecol Can.
2006;28(12):1095-8.
|
Follow-up on 517 women: Histological = 454
Cytological alone = 63 |
Prevalence of CIN II+ or HSIL according to
examination type: Histological = 363 (79.9%) Cytological alone =
11 (17.5%) |
Saad et al.1616. Saad RS, Dabbs DJ, Kordunsky L, et al. Clinical significance of
cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in
perimenopausal and postmenopausal women. Am J Clin Pathol.
2006;126(3):381-8.
|
Cytological and histological follow-up on women:
127 perimenopausal 90 postmenopausal |
Prevalence of CIN II+ or HSIL according to
menopausal period: perimenopausal = 28 (22.0%) postmenopausal =
5 (6%) |
Elsheikh et al.2020. Elsheikh TM, Kirkpatrick JL, Wu HH. The significance of
"low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous
intraepithelial lesion" as a distinct squamous abnormality category in
Papanicolaou tests. Cancer. 2006;108(5):277-81.
|
Comparative: Women with ASCUS = 410 Women with
ASC-H = 110 |
Prevalence of CIN II+ according to epithelial
cell abnormalities: ASCUS = 35 women (8.5%) ASC-H = 49 women
(44.6%) |
Srodon et al.33. Srodon M, Parry Dilworth H, Ronnett BM. Atypical squamous cells,
cannot exclude high-grade squamous intraepithelial lesion: diagnostic
performance, human papillomavirus testing, and follow-up results. Cancer.
2006;108(1):32-8.
|
Histological follow-up on HPV (+) women ASCUS =
266 ASC-H = 45 |
Prevalence of CIN II+ in HPV(+) patients: ASCUS
= 27 (10.2%) ASC-H = 18 (40.0%) |
McHale et al.2828. McHale MT, Souther J, Elkas JC, Monk BJ, Harrison TA. Is
atypical squamous cells that cannot exclude high-grade squamous intraepithelial
lesion clinically significant? J Low Genit Tract Dis.
2007;11(2):86-9.
|
Histological follow-up on 229 women |
Prevalence of CIN II/III according to time: At
the initial colposcopy, 23 of the patients (10%) had
histological evidence of CIN II/III. The cumulative risk of CIN
II/III was 12.2% at 12 months |
Gupta et al.1313. Gupta S, Sodhani P, Chachra KL, Singh V, Sehgal A. Outcome of
"Atypical squamous cells" in a cervical cytology screening program: implications
for follow up in resource limited settings. Diagn Cytopathol.
2007;35(11):677-80.
|
Colposcopic-histological follow-up: ASCUS = 218
women ASC-H = 52 |
Prevalence of CIN II/III or higher according to
epithelial cell abnormalities: ASCUS = 7 (3.2%) ASC-H = 16
(30.8%) |
Bonvicino et al.66. Bonvicino A, Huitron S, Fadare O. Papanicolaou test
interpretations of "atypical squamous cells, cannot exclude high-grade squamous
intraepithelial lesion": an investigation of requisite duration and number of
colposcopic procedures to a definitive diagnosis of high-grade dysplasia in
routine practice. Cancer. 2007;111(6):477-81.
|
Histological follow-up on 122 women |
Number of follow-up cervical biopsies for a
definitive diagnosis of CIN II+ First = 35 (72%) Second = 7
(14%) Third = 4 (8%) Fourth = 3 (6%) Total: 49 women (40%) with
CIN II+ |
Mokhtar et al.2929. Mokhtar GA, Delatour NL, Assiri AH, et al. Atypical squamous
cells, cannot exclude high-grade squamous intraepithelial lesion: cytohistologic
correlation study with diagnostic pitfalls. Acta Cytol.
2008;52(2):169-77.
|
Histological follow-up on 123 women |
Prevalence ratio of CIN II/III according to age
group > 40 years = 65.1% < 40 years = 47.5% |
Patton et al.55. Patton AL, Duncan L, Bloom L, Phaneuf G, Zafar N. Atypical
squamous cells, cannot exclude a high-grade intraepithelial lesion and its
clinical significance in postmenopausal, pregnant, postpartum, and
contraceptive-use patients. Cancer. 2008;114(6):481-8.
|
Histological follow-up on 195 women
Postmenopausal = 89 women Pregnant = 44 women Postpartum= 27
women Contraceptive use = 35 women |
Prevalence of CIN II+: Postmenopausal: 20 women
(22.5%) Pregnant: 35 women (79.6%) Postpartum 18 women (66.7%)
Contraceptive use: 21 (60%) The diagnosis of ASC-H in
postmenopausal Pap smears has a low predictive value in stark
contrast to the pregnant, postpartum, and contraceptive-use
categories |
Alsharif et al.2121. Alsharif M, Kjeldahl K, Curran C, et al. Clinical significance
of the diagnosis of low-grade squamous intraepithelial lesion, cannot exclude
high-grade squamous intraepithelial lesion. Cancer.
2009;117(2):92-100.
|
Histological follow-up on 691 women |
Prevalence of CIN II+ according to cytologic
categories: LSIL = 370 (16.1%) LSIL-H = 112 (33.1%) HSIL = 468
(69.0%) ASC-H = 182 (26.3%) |
Cytryn et al.77. Cytryn A, Russomano FB, Camargo MJ, et al. Prevalence of cervical
intraepithelial neoplasia grades II/III and cervical cancer in patients with
cytological diagnosis of atypical squamous cells when high-grade intraepithelial
lesions (ASC-H) cannot be ruled out. Sao Paulo Med J.
2009;127(5):283-7.
|
Histological follow-up on 57 women |
Prevalence of CIN II/III according to age group
of women : < 50 years = 10 (22.2%) 50 years or older = 1
(8.3%) Total: 11 women (19.3%) biopsy with CIN II+ |
Present study |
92 |
Prevalence of CIN II+: 56 women (60.9%) |