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Revista Brasileira de Hematologia e Hemoterapia

versão impressa ISSN 1516-8484

Resumo

TORRES, Margareth et al. HLA antibodies and donor selection. Rev. Bras. Hematol. Hemoter. [online]. 2010, vol.32, suppl.1, pp.06-07.  Epub 23-Abr-2010. ISSN 1516-8484.  http://dx.doi.org/10.1590/S1516-84842010005000025.

In spite of Anti-HLA antibodies being associated to rejection in solid organs transplantation, this correlation has not been well established yet in allogenic bone marrow transplantation.Recent studies in the literature have demonstrated that engraftment failure in hematopoietic cell transplantation (HCT) can be mediated by donor specific anti-HLA antibodies (DSA). These antibodies specificity can be detected by solid-phase techniques, where single HLA antigens are adhered to microbeads, which allows the interpretation of host reactivity by "virtual crossmatch". In the presence of DSA, it is advisable to either search for another donor or remove the antibodies prior to transplantation.

Palavras-chave : Transplantation; antibodies anti-HLA; rejection.

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