Resumo

PEREIRA, Kércia Regina Santos Gomes et al. Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy. Braz. arch. biol. technol. [online]. 2008, vol.51, n.spe, pp. 203-207. ISSN 1516-8913.  http://dx.doi.org/10.1590/S1516-89132008000700033.

Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity.

Palavras-chave : splenectomy; sodium phytate; biodistribution; liver.