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Einstein (São Paulo)

Print version ISSN 1679-4508On-line version ISSN 2317-6385


KOCH, Daeska Marcella  and  RATTMANN, Yanna Dantas. Use of misoprostol in the treatment of postpartum hemorrhage: a pharmacoepidemiological approach. Einstein (São Paulo) [online]. 2020, vol.18, eAO5029.  Epub Nov 07, 2019. ISSN 1679-4508.


To characterize the use of the drug misoprostol for treatment of postpartum hemorrhage in pregnant women.


A descriptive observational study was carried out with secondary data from pregnant women who used misoprostol to treat postpartum hemorrhage in a reference public maternity, from July 2015 to June 2017. Clinical and sociodemographic profiles of pregnant women, how misoprostol was used and success rate in controling postpartum hemorrhage were characterized.


A total of 717 prescriptions of misoprostol were identified. Of these, 10% were for treatment of postpartum hemorrhage. The majority of pregnant women were young adults, married, with complete high school education, white, residing in urban areas, multiparous (68.1%) and 25% had previous cesarean sections. The mean gestational age was 39 weeks and 51.4% had a cesarean section. There was prophylactic use of oxytocin in 47.2% of women. Treatment of postpartum hemorrhage was successful in 84.7% of women. Of these, 79.2% also used oxytocin and 54.2% methylergonovine. Only 13.5% of pregnant women had less than five prenatal visits, and the main cause of postpartum hemorrhage was uterine atony. There were 13 complications after hemorrhage, 15.3% required blood transfusion and there was one case of maternal death.


Misoprostol showed to be effective and safe for treating postpartum hemorrhage.

Keywords : Misoprostol; Delivery, obstetric; Pharmacoepidemiology; Postpartum hemorrhage; Treatment outcome.

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