Cochrane et al.20
|
9 |
Chewing gum with addition of CPP-ACP Chewing gum without addition of CPP-ACP Control Group without use of chewing gum |
14 days |
Degree of remineralization |
RCS In situ double-blind |
Shen et al.21
|
5 |
Cream/mousse based on CPP-ACP Fluoride 900 ppm associated with CPP-ACP Fluoride 1000 ppm Fluoride 5000 ppm Climpro 950 ppm Placebo |
10 days |
Degree of subsuperficial remineralization |
RCS In situ double-blind |
Walker et al.22
|
Study 1 10 participants
Study 2 14 participants |
In both studies, CPP-ACP-based “candies” were used:
Study 1 Control (65% sucrose + 33% glucose); Sugar + 0.5% (w/w) CPP-ACP; Sugar + 1.0% (w/w) CPP-ACP; -ACP Control free of sugar
Study 2 Control (65% sucrose + 33% glucose syrup); Sugar free + 0.5% (w/w) CPP Sugar + 1.0% (w/w) CPP-ACP; Control free of sugar |
10 days |
Degree of subsuperficial remineralization |
RCS In situ double-blind |
Srinivasan et al.23
|
5 |
Cream/mousse based on CPP-ACP
Cream/mousse based on CPP-ACP and fluoride 900 ppm Cream/mousse placebo *Treatment occurred 1 time per day for 3 minutes |
2 days |
Degree of subsurface remineralization in teeth that suffered erosion |
RCS In situ mono-blind |
Walker et al.24
|
10 |
100 mL cows milk based on CPP-ACP (0.2%) 100 mL cows milk based on CPP-ACP (0.3%)
100 mL cows milk without addition of CPP-ACP |
15 days |
Degree of subsuperficial remineralization
|
RCS In situ double-blind |
Cai et al.25
|
10 |
Chewing gum with or without addition of CPP-ACP |
14 days |
Degree of subsuperficial remineralization |
RCS In situ double-blind |
Robertson et al.26
|
60 |
CPP-ACP-based cream with addition of fluoride Cream placebo In both groups the product was applied 1 time per day, after night time brushing. |
3 months |
Prevention and reduction of white spots.
|
RCS In vivo double-blind |
Altenburge et al.27
|
32 |
Tooth brushing with fluoridated dentifrice and use of CPP-ACP-based cream, for 3 minutes, 1 time per day. Tooth brushing with fluoridated dentifrice |
3 weeks |
Evaluation of initial lesion of fissures in molars and premolars before and after treatment |
RCS in vivo mono-blind |
Beerens et al.28
|
54 |
CPP-ACP-based cream, associated with fluoride, applied before going to sleep. Placebo creamed based on calcium, applied before going to sleep |
3 months |
Degree of remineralization of white spot lesions and composition of bacterial plaque |
RCS In vivo double-blind |
Uysal et al.29
|
14 |
The brackets were bonded to premolars with 2 types of cement: Aegis Ortho® (composition based on ACP)
Concise® resin cement |
30 days |
Reduction of dental demineralization around orthodontic brackets |
RCS in vivo mono-blind |
Uysal et al.30
|
21 patients 60 teeth |
Cream based on CPP-ACP Fluoride in gel form No product was applied in the control group |
60 days (in vivo phase) 14 days (in vitro phase ) |
Reduction of dental demineralization around orthodontic brackets |
RCS in vivo and in vitro mono-blind |
Bröchner et al.31
|
60 patients |
Tooth brushing with fluoridated dentifrice in the morning, and application of CPP-ACP-based cream at night. Tooth brushing with fluoridated dentifrice in the morning, and at night. |
4 weeks |
Degrees of remineralization of white spot lesions |
RCS in vivo mono-blind |
Bailey et al.32
|
45 patients |
Cream based on CPP-ACP Cream placebo *Application was made twice a day, after tooth brushing with fluoridated dentifrice |
12 weeks |
Regression of white spot lesions |
RCS In vivo double-blind |