Ballantine et al. [1Ballantine JL, Carlson JC, Ferreira Zandoná AG, Agler C, Zeldin LP, Rozier RG, et al. Exploring the genomic basis of early childhood caries: a pilot study. Int J Paediatr Dent. 2018;28(2):217-225. https://doi.org/10.1111/ipd.12344 https://doi.org/10.1111/ipd.12344...
] |
2017 |
Cariology |
Verified the source of cellular differentiation and its potential regeneration of mineralized tissue in the control of caries. |
Alkharobi et al. [8Alkharobi H, Beattie J, Meade J, Devine D, El-Gendy R. Dental pulp cells isolated from teeth with superficial caries retain an inflammatory phenotype and display an enhanced matrix mineralization potential. Front Physiol. 2017;8:244. https://doi.org/10.3389/fphys.2017.00244 https://doi.org/10.3389/fphys.2017.00244...
] |
2018 |
Madiyal et al. [9Madiyal A, Babu S, Bhat S, Hegde P, Shetty A. Applications of stem cells in dentistry: A review. Gulhane Med J 2018;60:26-29.] |
2018 |
Salivary glands |
Modulation of the inflammatory processes and salivary fluid regulation. |
Lai et al. [10Lai Z, Yin H, Cabrera-Pérez J, Guimaro MC, Afione S, Michael DG, et al. Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice. Proc Natl Acad Sci U S A. 2016;113(20):5694-5699. https://doi.org/10.1073/pnas.1601992113 https://doi.org/10.1073/pnas.1601992113...
] |
2016 |
Ferreira et al. [11Ferreira JNA, Zheng C, Lombaert IMA, Goldsmith CM, Cotrim AP, Symonds JM, et al. Neurturin gene therapy protects parasympathetic function to prevent irradiation-induced murine salivary gland hypofunction. Mol Ther Methods Clin Dev. 2018;9:172-180. https://doi.org/10.1016/j.omtm.2018.02.008 https://doi.org/10.1016/j.omtm.2018.02.0...
] |
2018 |
Potdar & Jethmalani [12Potdar PD, Jethmalani YD. Human dental pulp stem cells: applications in future regenerative medicine. World J Stem Cells. 2015;7(5):839. https://doi.org/10.4252/wjsc.v7.i5.839 https://doi.org/10.4252/wjsc.v7.i5.839...
] |
2015 |
Dentinary tissue regeneration |
Accelerated differentiation of dentinary tissue from experiments with permanent teeth. |
Sonoda et al. [13Sonoda S, Mei YF, Atsuta I, Danjo A, Yamaza H, Hama S, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Scientific Rep. 2018;8(1):3419. https://doi.org/10.1038/s41598-018-21183-6 https://doi.org/10.1038/s41598-018-21183...
] |
2018 |
Atalayin et al. [14Atalayin C, Tezel H, Dagci Taner K, Yavasoglu NU, Oktem G. Medium modification with bone morphogenetic protein 2 addition for odontogenic differentiation. Braz Oral Res. 2016; 30(1):e20. https://doi.org/10.1590/1807-3107BOR-2016.vol30.0020 https://doi.org/10.1590/1807-3107BOR-201...
] |
2016 |
Kornman & Polverini [15Kornman KS, Polverini PJ. Clinical application of genetics to guide prevention and treatment of oral diseases. Clin Genet. 2014;86(1):44-49. https://doi.org/10.1111/cge12396 https://doi.org/10.1111/cge12396...
] |
2014 |
Sharpe [16Sharpe PT. Dental mesenchymal stem cells. Development. 2016;143(13):2273-2280. https://doi.org/10.1242/dev.134189 https://doi.org/10.1242/dev.134189...
] |
2016 |
Pang et al. [17Pang YW, Feng J, Daltoe F, Fatscher R, Gentleman E, Gentleman MM, et al. Perivascular Stem Cells at the Tip of Mouse Incisors Regulate Tissue Regeneration. J Bone Miner Res. 2016 Mar;31(3):514-23. https://doi.org/10.1002/jbmr.2717 https://doi.org/10.1002/jbmr.2717...
] |
2016 |
Aydin & Sahin [18Aydin S, ?ahin F. Stem cells derived from dental tissues. In: Turksen K. (eds) Cell biology and translational medicine. São Paulo: Springer; 2019.] |
2019 |
Potdar & Jethmalani [12Potdar PD, Jethmalani YD. Human dental pulp stem cells: applications in future regenerative medicine. World J Stem Cells. 2015;7(5):839. https://doi.org/10.4252/wjsc.v7.i5.839 https://doi.org/10.4252/wjsc.v7.i5.839...
] |
2015 |
Root tissue regeneration |
Mesenchymal cell reprogramming and differentiation of pulpal tissue. |
Akbar et al. [7Akbar A, Chatra L, Shenai P, Prabhu, Veena KM, Rachana V, et al. Stem cell therapy in Dentistry. WJPPS. 2017;6(4):1970-1981. http://dx.doi.org/10.20959/wjpps20174-9003 https://doi.org/10.20959/wjpps20174-9003...
] |
2017 |
Ledesma-Martínez et al. [19Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E. Mesenchymal stem cells derived from dental pulp: a review. Stem Cells Int. 2016;4709572. http://dx.doi.org/10.1155/2016/4709572 https://doi.org/10.1155/2016/4709572...
] |
2016 |
Sreedev et al. [20Sreedev CP, Karthick K, Mathew S, Iswarya Raju I. Regenerative endodontics: an overview. J Indian Acad Dental Spec Res. 2017;4(1):18. https://doi.org/10.4103/jiadsr.jiadsr_16_17 https://doi.org/10.4103/jiadsr.jiadsr_16...
] |
2017 |
Volponi et al. [21Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol. 2010;20(12):715-722. https://doi.org/10.1016/j.tcb.2010.09.012 https://doi.org/10.1016/j.tcb.2010.09.01...
] |
2017 |
Sharpe [16Sharpe PT. Dental mesenchymal stem cells. Development. 2016;143(13):2273-2280. https://doi.org/10.1242/dev.134189 https://doi.org/10.1242/dev.134189...
] |
2016 |
Anitua et al. [22Anitua E, Troya M, Zalduendo M. Progress in the use of dental pulp stem cells in regenerative medicine. Cytotherapy. 2018;20(4):479-498. https://doi.org/10.1016/j.jcyt.2017.12.011 https://doi.org/10.1016/j.jcyt.2017.12.0...
] |
2018 |
Chen et al. [23Chen FM, Gao LN, Tian BM, Zhang XY, Zhang YJ, Dong GY, et al. Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial. Stem Cell Res Ther. 2016;7(1):33. https://doi.org/10.1186/s13287-016-0288-1 https://doi.org/10.1186/s13287-016-0288-...
] |
2016 |
Periodontal diseases |
Tissue differentiation with potential of autogenous source of periodontal ligaments. |
Chen et al. [24Chen W, Gao B, Hao L, Zhu G, Jules J, MacDougall MJ, et al. Gene therapy of periodontal disease by AAV-shRNA silencing of Cathepsin K by inhibiting inflammation in periodontal lesion area. J Periodontal Res. 2016 Oct;51(5):647-60. https://doi.org/10.1111/jre.12345 https://doi.org/10.1111/jre.12345...
] |
2016 |
Akbar et al. [7Akbar A, Chatra L, Shenai P, Prabhu, Veena KM, Rachana V, et al. Stem cell therapy in Dentistry. WJPPS. 2017;6(4):1970-1981. http://dx.doi.org/10.20959/wjpps20174-9003 https://doi.org/10.20959/wjpps20174-9003...
] |
2017 |
Kornman & Polverini [15Kornman KS, Polverini PJ. Clinical application of genetics to guide prevention and treatment of oral diseases. Clin Genet. 2014;86(1):44-49. https://doi.org/10.1111/cge12396 https://doi.org/10.1111/cge12396...
] |
2014 |
Ledesma-Martínez et al. [19Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E. Mesenchymal stem cells derived from dental pulp: a review. Stem Cells Int. 2016;4709572. http://dx.doi.org/10.1155/2016/4709572 https://doi.org/10.1155/2016/4709572...
] |
2016 |
Volponi et al. [21Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol. 2010;20(12):715-722. https://doi.org/10.1016/j.tcb.2010.09.012 https://doi.org/10.1016/j.tcb.2010.09.01...
] |
2010 |
Sharpe [16Sharpe PT. Dental mesenchymal stem cells. Development. 2016;143(13):2273-2280. https://doi.org/10.1242/dev.134189 https://doi.org/10.1242/dev.134189...
] |
2016 |
Aurrekoetxea et al. [25Aurrekoetxea M, Garcia-Gallastegui P, Irastorza I, Luzuriaga J, Uribe-Etxebarria V, Unda F, et al. Dental pulp stem cells as a multifaceted tool for bioengineering and the regeneration of craniomaxillofacial tissues. Front Physiol. 2015 Oct 16;6:289. https://doi.org/10.3389/fphys.2015.00289. https://doi.org/10.3389/fphys.2015.00289...
] |
2015 |
Bone remodeling in Orthodontics and Implantodontics |
Contributing to orofacial harmony and substituting metallic implants. |
Vimalakshan et al. [3 Vimalakshan I, Ajantha HB, Kumar MP. Applications of gene therapy in dentistry: a review. Drug Invention Today. 2018;10(6):969-975.] |
2018 |
Madiyal et al. [9Madiyal A, Babu S, Bhat S, Hegde P, Shetty A. Applications of stem cells in dentistry: A review. Gulhane Med J 2018;60:26-29.] |
2018 |
Padial-Molina et al. [26 Padial-Molina M, O’Valle F, Lanis A, Mesa F, Dohan Ehrenfest DM, Wang HL et al. Clinical application of mesenchymal stem cells and novel supportive therapies for oral bone regeneration. BioMed Res Int. 2015:341327. https://doi.org/10.1155/2015/341327 https://doi.org/10.1155/2015/341327...
] |
2015 |
Enezei et al. [27Enezei HH, Ahmad A, Takeuchi K, Suzuki J, Khamis MF, Razak NHA, et al. Osteoinductive Activity of Bone Scaffold Bioceramic Companied with Control Release of VEGF Protein Treated Dental stem cells as A New Concept for Bone Regeneration: Part II. J Hard Tissue Biol. 2018;27(1):69-78. https://doi.org/10.2485/jhtb.27.69 https://doi.org/10.2485/jhtb.27.69...
] |
2018 |
Akbar et al. [7Akbar A, Chatra L, Shenai P, Prabhu, Veena KM, Rachana V, et al. Stem cell therapy in Dentistry. WJPPS. 2017;6(4):1970-1981. http://dx.doi.org/10.20959/wjpps20174-9003 https://doi.org/10.20959/wjpps20174-9003...
] |
2017 |
Ledesma-Martínez et al. [19Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E. Mesenchymal stem cells derived from dental pulp: a review. Stem Cells Int. 2016;4709572. http://dx.doi.org/10.1155/2016/4709572 https://doi.org/10.1155/2016/4709572...
] |
2016 |
Volponi et al. [21Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol. 2010;20(12):715-722. https://doi.org/10.1016/j.tcb.2010.09.012 https://doi.org/10.1016/j.tcb.2010.09.01...
] |
2010 |
Sharpe [16Sharpe PT. Dental mesenchymal stem cells. Development. 2016;143(13):2273-2280. https://doi.org/10.1242/dev.134189 https://doi.org/10.1242/dev.134189...
] |
2016 |
Shanbhag et al. [28Shanbhag S, Suliman S, Pandis N, Stavropoulos A, Sanz M, Mustafa K. Cell therapy for orofacial bone regeneration: A systematic review and meta-analysis. J Clin Periodontol. 2019;46 Suppl 21:162-182. https://doi.org/10.1111/jcpe.13049 https://doi.org/10.1111/jcpe.13049...
] |
Aczél et al. [2Aczél T, Kun J, Szőke É, Rauch T, Junttila S, Gyenesei A, et al. Transcriptional alterations in the trigeminal ganglia, nucleus and peripheral blood mononuclear cells in a rat orofacial pain model. Front Mol Neurosci. 2018;11:219. https://doi.org/10.3389/fnmol.2018.00219 https://doi.org/10.3389/fnmol.2018.00219...
] |
2018 |
Orofacial pain |
Controlling neural excitability with satisfactory response to orofacial analgesia. |
Guedon et al. [29Guedon JMG, Wu S, Zheng X, Churchill CC, Glorioso JC, Liu CH. Current gene therapy using viral vectors for chronic pain. Mol Pain. 2015;11:27. https://doi.org/10.1186/s12990-015-0018-1 https://doi.org/10.1186/s12990-015-0018-...
] |
2015 |
Shinoda [30Shinoda M, Iwata K. Neural communication in the trigeminal ganglion contributes to ectopic orofacial pain. J Oral Biosci. 2013;55:165-168. https://doi.org/10.1016/j.job.2013.06.003 https://doi.org/10.1016/j.job.2013.06.00...
] |
2013 |