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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790

Resumo

SOUZA, Tatiane Pereira de; GOMEZ-AMOZA, José Luiz; PACHECO, Ramón Martínez  e  PETROVICK, Pedro Ros. Development of granules from Phyllanthus niruri spray-dried extract. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.4, pp.669-675. ISSN 2175-9790.  http://dx.doi.org/10.1590/S1984-82502009000400009.

The aim of this study was to develop granules from Phyllanthus niruri spray-dried extract using dry and wet granulation and to assess techniques to enable the production of granules with improved technological characteristics and yields. Granules were characterized by granulometry, reological parameters, compression and hygroscopic behavior. Independent of the granulation technique, technologically developed granules presented particle diameter, bulk and tapped densities and compressibility indexes suitable for a solid dosage form. The compression behavior showed plastic and fragmentary deformation for granules produced by the dry granulation technique and predominantly plastic deformation for wet granulation. Concerning the humidity sorption, the study showed that granules absorb less humidity than the spray-dried extract. However, granules with Eudragit® E 100 were the least hygroscopic.

Palavras-chave : Phyllantus nururi [pharmacotechnics]; Granules [production]; Spray-dried extract; Wet granulation; Dry granulation.

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