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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790


ALVES, Naiane Ferraz Bandeira; PORPINO, Suênia Karla Pacheco  e  SILVA, Alexandre Sérgio. The period between beta-blocker use and physical activity changes training heart rate behavior. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.4, pp.729-735. ISSN 2175-9790.

The Brazilian Society of Cardiology (SBC) proposes that hypertensive subjects who use beta-blockers and practice physical exercises must have their training heart rate (HR) corrected due to the negative chronotropic effect of this drug. Nevertheless, if the physical activity is performed outside of plasmatic half-life, correction may not be necessary. This study investigated the exercise chronotropic response both inside and outside the beta-blocker plasmatic half-life. Nine subjects in use of atenolol or propranolol, and six controls, carried out three walking sessions in three days according to different schedules: EX2 (two hours after drug administration, at the plasmatic peak); EX11 (eleven hours after drug administration, at the end of plasmatic half-life); and EX23 (twenty-three hours after drug administration, outside the plasmatic half-life. The walking sessions were performed on an ergometric treadmill and HR was monitored by a heart rate monitor. During the exercises, mean HRs were 97.2, 108.4 and 109 for EX2, EX11 and EX23, respectively, with the value for EX2 statistically lower than the others (p<0.05). There were no statistical differences in the control group (p>0.05). The study concludes that the attenuation of the positive chronotropic response which occurs during exercise in subjects using beta-blockers, is less evident when the exercise is performed outside the plasmatic half-life of the drug.

Palavras-chave : Beta-blockers [negative chronotropic effect]; Atenolol; Propanolol; Hypertension; Physical exercise; Training heart rate [control].

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