SciELO - Scientific Electronic Library Online

vol.45 número4The period between beta-blocker use and physical activity changes training heart rate behaviorStudy of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790


CESAR, Isabela da Costa  e  PIANETTI, Gerson Antônio. Quantitation of artemether in pharmaceutical raw material and injections by high performance liquid chromatography. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.4, pp.737-742. ISSN 2175-9790.

The quantitation of artemether in both pharmaceutical raw material and injections was carried out by high performance liquid chromatography (HPLC) with ultraviolet detection. A Zorbax C18 column (150 x 4.6 mm; 5 μm), at 30 °C, and a mobile phase composed of acetonitrile and water (70:30), at a flow rate of 1ml/min, were used. The detection wavelength was 216 nm and the injection volume was 20 μL. The method proved to be linear (r2=0.9999), precise (RSD < 20% for intra-day and inter-day precision), accurate and selective regarding possible impurities and excipients of the samples. The detection and quantitation limits were 8 μg/mL and 25 μg/mL, respectively. The artemether content obtained in the raw material analysis was 99.26% and in the injections, 102.08%. The optimized and validated method may be successfully employed to perform routine quality control analyses.

Palavras-chave : Artemether [quantitation]; High performance liquid chromatography [quantitative analysis]; Antimalarials.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )


Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons