Bentzen66 Bentzen SM, Balslev I, Pedersen M, Teglbjaerg PS, Hanberg-Soerensen F, Bone J, et al. A regression analysis of prognostic factors after resection of Dukes' B and C carcinoma of the rectum and rectosigmoid. Does post-operative radiotherapy change the prognosis?. Br J Cancer. 1988;58:195-201.
|
1988 |
Denmark |
494 |
Prospective |
258/236 |
64.1 |
NR |
129 (26.11) |
A |
Duke |
Duke B/C |
OS |
3 |
Ceyhan77 Ceyhan GO, Liebl F, Maak M, Schuster T, Becker K, Langer R, et al. The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy. Ann Surg. 2010;252:797-804.
|
2010 |
Germany |
296 |
Retrospective |
184/112 |
62.8 |
60 |
73 (24.7) |
P |
UICC 2009 |
IIa |
OS |
3 |
Chandrasinghe88 Chandrasinghe PC, Ediriweera DS, Kumarage SK, Deen KI. Preoperative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis. BMC Clin Pathol. 2013;13:12.
|
2013 |
Sri Lanka |
226 |
Retrospective |
123/103 |
59 |
60 |
25 (11.06) |
P |
AJCC |
AJCC I/II/III/IV |
OS |
2 |
Dresen99 Dresen RC, Peters EE, Rutten HJ, Nieuwenhuijzen GA, Demeyere TB, van den Brule AJ, et al. Local recurrence in rectal cancer can be predicted by histopathological factors. Eur J Surg Oncol. 2009;35:1071-7.
|
2009 |
Netherlands |
277 |
Retrospective |
163/104 |
62 |
66 |
20 (7.22) |
P |
UICC |
I/II/III |
OS |
2 |
Guillem1010 Guillem JG, Chessin DB, Cohen AM, Shia J, Mazumdar M, Enker W, et al. Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer. Ann Surg. 2005;241:829-36, discussion 836–8.
|
2005 |
USA |
297 |
Retrospective |
186/111 |
62 |
44 |
27 (9.09) |
P |
AJCC |
AJCC I/II/III/IV |
OS |
2 |
Kim1111 Kim JS, Sohn DK, Park JW, Kim DY, Chang HJ, Choi HS, et al. Prognostic significance of distribution of lymph node metastasis in advanced mid or low rectal cancer. J Surg Oncol. 2011;104:486-92.
|
2011 |
Korea |
797 |
Prospective |
515/282 |
59 |
44.7 |
215 (26.9) |
A |
AJCC |
AJCC I/II/III |
OS |
2 |
Knudsen1212 Knudsen JB, Nilsson T, Sprechler M, Johansen A, Christensen N. Venous and nerve invasion as prognostic factors in postoperative survival of patients with resectable cancer of the rectum. Dis Colon Rectum. 1983;26:613-7.
|
1983 |
Denmark |
682 |
Retrospective |
324/358 |
67 (mean) |
NR |
34.4 (Dukes), 33.1 (Broders) |
N |
Duke/Broders |
Dukes A/B/C, Broders I/II/III/IV |
OS |
2 |
Lim1313 Lim JW, Chew MH, Lim KH, Tang CL. Close distal margins do not increase rectal cancer recurrence after sphincter-saving surgery without neoadjuvant therapy. Int J Colorectal Dis. 2012;27:1285-94.
|
2012 |
Singapore |
320 |
Prospective |
212/108 |
64 |
45 |
48 (15) |
P |
AJCC |
I/II/III |
OS/DFS |
2 |
Peng1414 Peng J, Sheng W, Huang D, Venook AP, Xu Y, Guan Z, et al. Perineural invasion in pT3N0 rectal cancer: the incidence and its prognostic effect. Cancer. 2011;117:1415-21.
|
2011 |
China |
173 |
Retrospective |
109/64 |
57 |
49 |
42 (24.28) |
N |
NR |
II |
OS/DFS/Recurrence |
2 |
Poeschl1515 Poeschl EM, Pollheimer MJ, Kornprat P, Lindtner RA, Schlemmer A, Rehak P, et al. Perineural invasion: correlation with aggressive phenotype and independent prognostic variable in both colon and rectum cancer. J Clin Oncol. 2010;28:e358-60.
|
2010 |
Austria |
381 |
Retrospective |
NR |
NR |
56 |
NR |
NR |
NR |
NR |
OS/DFS |
2 |
Rullier1616 Rullier A, Laurent C, Vendrely V, Le Bail B, Bioulac-Sage P, Rullier E, et al. Impact of colloid response on survival after preoperative radiotherapy in locally advanced rectal carcinoma. Am J Surg Pathol. 2005;29:602-6.
|
2005 |
France |
495 |
Prospective |
313/182 |
65 (mean) |
48 |
31(15.5) |
A |
5th UICC |
II/III |
OS/DFS |
2 |
Ueno1717 Ueno H, Hase K, Mochizuki H. Criteria for extramural perineural invasion as a prognostic factor in rectal cancer. Br J Surg. 2001;88:994-1000.
|
2001 |
Japan |
364 |
Prospective |
222/142 |
60.6 (mean) |
92 |
52 (14) |
N |
NR |
NR |
OS/Recurrence |
2 |
Peng1818 Peng J, Chen W, Sheng W, Xu Y, Cai G, Huang D, et al. Oncological outcome of T1 rectal cancer undergoing standard resection and local excision. Colorectal Dis. 2011;13:e14-9.
|
2011 |
China |
124 |
Retrospective |
53/71 |
50 |
72 (median) |
12 (9.7) |
N |
AJCC |
I |
OS/DFS |
3 |
Stewart1919 Stewart D, Yan Y, Mutch M, Kodner I, Hunt S, Lowney J, et al. Predictors of disease-free survival in rectal cancer patients undergoing curative proctectomy. Colorectal Dis. 2008;10:879-86.
|
2008 |
USA |
304 |
Retrospective |
157/147 |
66 |
27 (median) |
11 (5.21) |
P |
6th AJCC |
I/II/III/IV |
DFS |
3 |
Lee2020 Lee JH, Jang HS, Kim JG, Cho HM, Shim BY, Oh ST, et al. Lymphovascular invasion is a significant prognosticator in rectal cancer patients who receive preoperative chemoradiotherapy followed by total mesorectal excision. Ann Surg Oncol. 2012;19:1213-21.
|
2012 |
Korea |
328 |
Prospective |
222/106 |
59 |
45 (median) |
66 (20.1) |
A |
7th AJCC |
I/II/III |
OS, DFS |
2 |
Dhadda2121 Dhadda AS, Bessell EM, Scholefield J, Dickinson P, Zaitoun AM. Mandard tumour regression grade, perineural invasion, circumferential resection margin and post-chemoradiation nodal status strongly predict outcome in locally advanced rectal cancer treated with preoperative chemoradiotherapy. Clin Oncol (R Coll Radiol). 2014;26:197-202.
|
2014 |
UK |
158 |
Prospective |
105/53 |
65 |
40 |
58 (17.72) |
A |
NR |
II/III |
DFS |
2 |
Bognel2222 Bognel C, Rekacewicz C, Mankarios H, Pignon JP, Elias D, Duvillard P, et al. Prognostic value of neural invasion in rectal carcinoma: a multivariate analysis on 339 patients with curative resection. Eur J Cancer. 1995;31A:894-8.
|
1995 |
France |
339 |
Retrospective |
166/173 |
61.8 |
61 |
115 (34) |
P |
Astler-Coller |
A,B,C |
OS |
2 |
Liebig55 Liebig C, Ayala G, Wilks J, Verstovsek G, Liu H, Agarwal N, et al. Perineural invasion is an independent predictor of outcome in colorectal cancer. J Clin Oncol. 2009;27:5131-7.
|
2009 |
USA |
66 |
Retrospective |
NR |
NR |
81 |
19 (30) |
NR |
TNM |
I/II/III/IV |
DFS, OS |
2 |
Vlad2323 Vlad C, Kubelac P, Vlad D, Irimie A, Achimas Cadariu P. Evaluation of clinical, morphopathological and therapeutic prognostic factors in rectal cancer. Experience of a tertiary oncology center. J BUON. 2015;20:92-9.
|
2012 |
Romania |
317 |
Prospective |
201/116 |
54 (mean) |
66 |
60 (19) |
P |
TNM |
I/II/III/IV |
DFS, OS |
3 |