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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.42 no.3 São Paulo Sept. 1984

http://dx.doi.org/10.1590/S0004-282X1984000300009 

Hipertrofia muscular em desenervaçao. Relato de dois casos com estudo histoquímico e histométrico dos músculos normais e hipertróficos

 

Muscle hypertrophy in denervation. Report of two cases with muscle histochemistry and histometric analysis

 

 

Lineu Cesar WerneckI; Vicente CaropresoII

IProfessor Assistente. Departamento de Clínica Médica, da Universidade Federal do Paraná
IIMédico Residente. Departamento de Clínica Médica, da Universidade Federal do Paraná

 

 


RESUMO

Relato de dois pacientes do sexo masculino, com 31 e 24 anos de idade, que apresentavam hipertrofia muscular localizada no membro inferior esquerdo, cuja investigação revelou sinais de desenervação pela eletromiografia. Foram submetidos a biópsia muscular no lado normal e no hipertrófico, processadas por histoquímica. Posteriormente, foi calculado o diâmetro médio das fibras, percentagem de tipo específico de fibras, fatores de atrofia e hipertrofia, bem como foi feita análise histográfica dos tipos de fibras. Foi encontrada grande quantidade de fibras hipertróficas, raras fibras atróficas e, na diferenciação histoquímica, um dos pacientes apresentava hipertrofia de fibras do tipo II e o outro hipertrofia tanto de fibras do tipo I, como II. Pelo cálculo dos fatores de atrofia e hipertrofia, existia predominantemente hipertrofia de fibras do tipo II em ambos os quadriceps nos dois casos e hipertrofia de fibras do tipol no caso 2. São discutidos os fatores causadores de hipertrofia em desenervação sendo que no caso 1 a etiologia foi possivelmente radiculite de SI e, no caso 2, secundária a doença do neurônio motor inferior.


SUMMARY

Report of two adult males, 31 and 24 years-old, with hypertrophy in their left inferior limb, with denervation in the electromyography. Both patients undergone to a muscle biopsy in the normal and in the enlarged limb, which were processed by histochemistry. The mean muscle fiber diameter, percentage of muscle type fibers and atrophy and hypertrophy factors were calculated, as well as histographic fiber analysis. We found rare atrophic muscle fibers and one of the patients had hypertrophy of type II muscle fiber and the other hypertrophy of both types. The calculation of the atrophy and hypertrophy factors, revealed a predominance of type II fiber hypertrophy in both quadriceps of the two patients and type I hypertrophy in one case. A discussion about the factor responsible by the hypertrophy in denervation is made. The possible etiology of one case was a SI radiculopathy and in the other, a possible motor neuron disease.


 

 

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Trabalho realizado na Especialidade de Neurologia do Departamento de Clínica Médica, da Universidade Federal do Paraná.
Especialidade de Neurologia, Departamento de Clinica Médica - Hospital de Clínicas da Universidade Federal do Paraná - Rua General Carneiro 180, 13° andar - 80.000, Curitiba, PR - Brasil.

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