Chorea as a sign of systemic lupus erythematosus activity: case report

Caramelli, P.; Toledo, S.M.; Marchiori, P.E.; Barbosa, E.R.; Scaff, M.

doi:10.1590/S0004-282X1993000200021

Abstracts

Chorea may occur as a neurological manifestation of systemic lupus erythematosus and is often associated with detection of antiphospholipid antibodies. No evidence of chorea as a sign of lupus activity has been established. We describe a patient with systemic lupus erythematosus associated with antiphospholipid antibodies who developed chorea, which has been considered a sign of lupus activity.

chorea; systemic lupus erythematosus; lupus activity

Coréia pode ocorrer como manifestação neurológica do lupus eritematoso sistêmico, estando frequentemente associada à presença de anticorpos antifosfolípides. Evidência de coréia como sinal de atividade lúpica não foi descrita. Descrevemos o caso de uma paciente, com lupus eritematoso sistêmico e anticorpos antifosfolípides, que desenvolveu coréia, sendo esta manifestação considerada sinal de atividade dia doença.

coréia; lupus eritematoso sistêmico; lupus em atividade

Chorea as a sign of systemic lupus erythematosus activity: case report

Coréia como sinal de atividade do hipus eritematoso sistêmico: relato de caso

P. Caramelli^I; S.M. Toledo^I; P.E. Marchiori^II; E.R. Barbosa^III; M. Scaff^IV

^IMédico Pós-Graduando. Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo

^IIProfessor Associado. Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo

^IIIMédico Assistente. Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo

^IVProfessor Titular. Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo

SUMMARY

Chorea may occur as a neurological manifestation of systemic lupus erythematosus and is often associated with detection of antiphospholipid antibodies. No evidence of chorea as a sign of lupus activity has been established. We describe a patient with systemic lupus erythematosus associated with antiphospholipid antibodies who developed chorea, which has been considered a sign of lupus activity.

Key words: chorea, systemic lupus erythematosus, lupus activity.

RESUMO

Coréia pode ocorrer como manifestação neurológica do lupus eritematoso sistêmico, estando frequentemente associada à presença de anticorpos antifosfolípides. Evidência de coréia como sinal de atividade lúpica não foi descrita. Descrevemos o caso de uma paciente, com lupus eritematoso sistêmico e anticorpos antifosfolípides, que desenvolveu coréia, sendo esta manifestação considerada sinal de atividade dia doença.

Palavras-chave: coréia, lupus eritematoso sistêmico, lupus em atividade.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Aceite: 11-setembro-1992.

Dr. Paulo Caramelli Divisão de Neurologia, Hospital das Clínicas, FMUSP Caixa Postal 8091 01065-970 São Paulo SP Brasil.

1. Asherson RA, Derksen RHWM, Harris EN, Bouma BN, Gharavi AE, Kater L, Hughes GRV. Chorea in systemic lupus erythematosus and "lupus-like" disease: association with antiphospholipid antibodies. Semin Arthritis Rheum 1987, 16:253-259.
2. Asherson RA, Harris EN. Anticardiolipin antibodies: clinical associations. Postgrad Med J 1986, 62:1081-1087.
3. Bingley PJ, Hoffbrand BI. Antiphospholipid antibody syndrome: a review. J R Soc Med 1987, 80:445-448.
4. Bouchez B, Arnott G, Hatron PY, Wattel A, Devulder B. Chorée et lupus érythémateux disséminé avec anticoagulant circulant: trois cas. Rev Neurol 1985, 141:571-577.
6. Carreras LO, Vermylen JG. Lupus anticoagulant and thrombosis: possible role of inhibition of prostacyclin formation. Thromb Haemost 1982, 48:28-40.
6. Greenhouse AH. On chorea, lupus erythematosus, and cerebral arteristis. Arch Intern Med 1966, 117:389-393.
7. Kamashta MA, Gil A, Anciones B, Lavilla P, Valencia ME, Pintado V, Vázquez JJ. Chorea in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis 1988, 47:681-683.
8. Levine SR, Welch KMA. The spectrum of neurologic disease associated with antiphospholipid antibodies. Arch Neurol 1987, 44:876-883.
9. Lusins JO, Szilagyi PA. Clinical features of chorea associated with systemic lupus erythematosus. Am J Med 1975, 58:857-861.
10. Marchiori PE, Reis M, Quevedo MEZ, Callegaro D, Hirata MTA, Scaff M, Oliveira RM. Cerebrospinal fluid and serum antiphospholipid antibodies in multiple sclerosis, Guillain-Barre syndrome and systemic lupus erythematosus. Arq Neu quiat (São Paulo) 1990, 48:465-468.
11. Urowitz, MG, Gladman DD, Tozman ECS, Goldsmith CH. The lupus activity criteria count (LACC). J Rheumatol 1984, 11:783-787.

Publication Dates

Publication in this collection
19 Jan 2011
Date of issue
June 1993

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Asherson RA, Derksen RHWM, Harris EN, Bouma BN, Gharavi AE, Kater L, Hughes GRV. Chorea in systemic lupus erythematosus and "lupus-like" disease: association with antiphospholipid antibodies. Semin Arthritis Rheum 1987, 16:253-259.

[2] 2. Asherson RA, Harris EN. Anticardiolipin antibodies: clinical associations. Postgrad Med J 1986, 62:1081-1087.

[3] 3. Bingley PJ, Hoffbrand BI. Antiphospholipid antibody syndrome: a review. J R Soc Med 1987, 80:445-448.

[4] 4. Bouchez B, Arnott G, Hatron PY, Wattel A, Devulder B. Chorée et lupus érythémateux disséminé avec anticoagulant circulant: trois cas. Rev Neurol 1985, 141:571-577.

[5] 6. Carreras LO, Vermylen JG. Lupus anticoagulant and thrombosis: possible role of inhibition of prostacyclin formation. Thromb Haemost 1982, 48:28-40.

[6] 6. Greenhouse AH. On chorea, lupus erythematosus, and cerebral arteristis. Arch Intern Med 1966, 117:389-393.

[7] 7. Kamashta MA, Gil A, Anciones B, Lavilla P, Valencia ME, Pintado V, Vázquez JJ. Chorea in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis 1988, 47:681-683.

[8] 8. Levine SR, Welch KMA. The spectrum of neurologic disease associated with antiphospholipid antibodies. Arch Neurol 1987, 44:876-883.

[9] 9. Lusins JO, Szilagyi PA. Clinical features of chorea associated with systemic lupus erythematosus. Am J Med 1975, 58:857-861.

[10] 10. Marchiori PE, Reis M, Quevedo MEZ, Callegaro D, Hirata MTA, Scaff M, Oliveira RM. Cerebrospinal fluid and serum antiphospholipid antibodies in multiple sclerosis, Guillain-Barre syndrome and systemic lupus erythematosus. Arq Neu quiat (São Paulo) 1990, 48:465-468.

[11] 11. Urowitz, MG, Gladman DD, Tozman ECS, Goldsmith CH. The lupus activity criteria count (LACC). J Rheumatol 1984, 11:783-787.