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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.52 no.1 São Paulo Mar. 1994

http://dx.doi.org/10.1590/S0004-282X1994000100017 

Cerebellar atrophy related to chronic exposure to toluene: case report

 

Atrofia cerebelar relacionada à exposição ocupacional crônica ao tolueno: relato de caso

 

 

Benito Pereira DamascenoI; Eduardo Mello de CapitaniII

IFaculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (UNICAMP): Departament of Neurology
IIFaculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (UNICAMP): Department of Preventive and Social Medicine

 

 


SUMMARY

A 31-year-old woman presented slowly progressing ataxia and neurasthenic symptoms after 14-year occupational exposure to low concentration toluene vapour. Examination disclosed only cerebellar signs. Cognitive functions were normal except moderate visuo-spatial and constructive deficit CT imaging showed severe pancerebellar atrophy without pathological signs in other brain structures. Two years after she was removed from workplace, CT imaging and ataxia showed no worsening, while visuo-constructive function improved. The authors warn against possible neurotoxic risk associated with this kind of exposure.

Key-words: cerebellar atrophy, organic solvent toxicity, toluene.


RESUMO

Uma mulher de 31 anos desenvolveu síndrome cerebelar e neurastênica, de evolução lentamente progressiva, após 14 anos de exposição ocupacional a vapores de tolueno em baixas concentrações. Os únicos achados do exame neurológico e neuropsicológico foram sinais cerebelares (severos) e déficit visuo-espacial e práxico-construcional (moderado). A neuroimagem tomográfica mostrava acentuada atrofia pancerebelar, com preservação das outras estruturas cerebrais. Dois anos após interrompida a exposição, a ataxia e a neuroimagem (TC) estavam inalteradas, enquanto a função visuo-construcional havia parcialmente melhorado. Os autores chamam a atenção para o possível risco neurotóxico relacionado a esse tipo de exposição, numa tentativa de prevenção de casos semelhantes.

Palavras-chaves: atrofia cerebelar, neurotoxicidade, solventes orgânicos, tolueno.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Acknowledgements- We are grateful to engineers Ivo T. Borges and Luis A. Borges for analysing material collected at the patient's workplace.

 

REFERENCES

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10. Wikkelsö C, Ekberg K, Lillienberg L, Wetterholm B, Karlsson B, Blomstrand C, Johansson BB. Cerebrospinal fluid proteins and cells in men subjected to long-term exposure to organic solvents. Acta Neurol Scand 1984, 70 (Suppl 100): 113-119.         [ Links ]

 

 

Aceite: 10-julho-1993.

 

 

Dr. Benito Pereira Damasceno - Departamento de Neurologia, FCM/UNICAMP - Caixa Postal 6111 - 13081-970 Campinas SP - Brasil.

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