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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.2 São Paulo June 1995 

Familial glioblastoma


Glioblastoma familiar



Walter O. ArrudaI; Rogério S. ClementeII; Ricardo RaminaII; Ari A. PedrozoII; Rui F. PilottoIII; Walter Pinto Jr.IV; Luiz F. Bleggi-torresV

IIIGeneticista, Unidade de Genética Médica, Universidade Federal do Paraná
IVGeneticista, Departamento de Genética Médica, UNICAMP
VNeuropatologista, Unidade de Ciências Neurológicas, Hospital das Nações, Curitiba




The authors describe a family with three members affected by glioblastoma. The proband patient, a 7 year-old girl, developed a rare complication, a pulmonary metastasis. Chromosomal analysis of her peripheral blood lymphocytes showed a normal karyotype (46, XX), without structural abnormalities. Cytogenetic study of the tumor cells disclosed several abnormalities: 46, XX, 7q - / 46, XX, -2, 4p-, 7p-, +15/ 46, XX. Some aspects about genetics of glial neoplasms are discussed.

Key words: glioblastoma, chromosomes, cytogenetics, oncogenesis.


Os autores descrevem uma família com três membros portadores de glioblastoma. A paciente probanda, uma menina de 7 anos, apresentou metástase pulmonar. A análise cromossômica dos linfócitos periféricos revelou um cariótipo normal (46, XX). Estudo citogenético das células tumorais mostrou várias anormalidades: 46, XX, 7q- / 46, XX, -2,4p-, 7p-, +15 / 46, XX. Alguns aspectos sobre oncogênese e citogenética das neoplasias gliais são discutidos.

Palavras-chave:glioblastoma, cromossomos, citogenética, oncogênese.



Texto completo disponível apenas em PDF.

Full text available only in PDF format.




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Aceite: 24-outubro-1994.

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