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Arquivos de Neuro-Psiquiatria

versão impressa ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.2 São Paulo jun. 1995

http://dx.doi.org/10.1590/S0004-282X1995000200025 

Familial glioblastoma

 

Glioblastoma familiar

 

 

Walter O. ArrudaI; Rogério S. ClementeII; Ricardo RaminaII; Ari A. PedrozoII; Rui F. PilottoIII; Walter Pinto Jr.IV; Luiz F. Bleggi-torresV

INeuroIogista
IINeurocirurgião
IIIGeneticista, Unidade de Genética Médica, Universidade Federal do Paraná
IVGeneticista, Departamento de Genética Médica, UNICAMP
VNeuropatologista, Unidade de Ciências Neurológicas, Hospital das Nações, Curitiba

 

 


SUMMARY

The authors describe a family with three members affected by glioblastoma. The proband patient, a 7 year-old girl, developed a rare complication, a pulmonary metastasis. Chromosomal analysis of her peripheral blood lymphocytes showed a normal karyotype (46, XX), without structural abnormalities. Cytogenetic study of the tumor cells disclosed several abnormalities: 46, XX, 7q - / 46, XX, -2, 4p-, 7p-, +15/ 46, XX. Some aspects about genetics of glial neoplasms are discussed.

Key words: glioblastoma, chromosomes, cytogenetics, oncogenesis.


RESUMO

Os autores descrevem uma família com três membros portadores de glioblastoma. A paciente probanda, uma menina de 7 anos, apresentou metástase pulmonar. A análise cromossômica dos linfócitos periféricos revelou um cariótipo normal (46, XX). Estudo citogenético das células tumorais mostrou várias anormalidades: 46, XX, 7q- / 46, XX, -2,4p-, 7p-, +15 / 46, XX. Alguns aspectos sobre oncogênese e citogenética das neoplasias gliais são discutidos.

Palavras-chave:glioblastoma, cromossomos, citogenética, oncogênese.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Aceite: 24-outubro-1994.