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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.54 no.3 São Paulo Sept. 1996

http://dx.doi.org/10.1590/S0004-282X1996000300013 

Aspectos genéticos da esclerose múltipla: II. sistema HLA

 

Genetic aspects in multiple sclerosis: HLA system

 

 

Patrícia Almeida de RezendeI; Walter Oleschko ArrudaII

IMestre em Genética, Universidade Federal do Paraná (UFPR)
IINeurologista

 

 


RESUMO

Foi feita análise e revisão de estudos populacionais de associação entre antígenos HLA e a esclerose múltipla (EM). Há evidências de que os genes HLA, principalmente os de classe II, das sub-regiões DR e DQ possam estar envolvidos. O haplótipo DRB1*1501.DQA1*0102.DQB1*0602 referente ao fenótipo DR2.Dw2.DQ6 foi encontrado em associação positiva em vários estudos realizados em populações caucasóides. O desequilíbrio de ligação entre os genes DR e DQ dificulta o reconhecimento da contribuição individual de cada alelo. A heterogeneidade de critérios diagnósticos da EM constitui importante fator metodológico que dificulta a comparação entre os diversos estudos. A padronização dos critérios diagnósticos e dos métodos laboratoriais empregados, assim como a análise individual de grupos de pacientes com formas clínicas diferentes, são medidas que provavelmente permitirão avaliação mais precisa dos fatores genéticos envolvidos no desenvolvimento da EM.

Palavras-chave: esclerose múltipla, sistema HLA, genética.


ABSTRACT

Review of studies about HLA antigens and multiple sclerosis (MS). The HLA system, in special class II antigens, subregions DR and DQ, is probably involved in the immunopathogenesis of MS. Haplotype DRB1*1501.DQA1*0102.DQB1*0602, corresponding to phenotype DR2.Dw2.DQ6, is positively associated with MS in several caucasoid populations. Clinical heterogeneity of MS, as well as different diagnostic criteria adopted by investigators are potential sources of confusion and may lead to discrepant results. A better standardization of clinical and laboratorial methodology, appropriate subdivision of patients with different clinical forms of MS, may allow a more accurate evaluation of the role of genetic factors in the pathogenesis of MS.

Key words: multiple sclerosis, HLA system, genetics.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Agradecimentos - Ao apoio financeiro de CAPES, ao Sr. Armando Guedes Vicentini pelo seu inestimável apoio na elaboração deste estudo.

 

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Aceite: 14-março-1996.

 

 

Dr Walter O. Arruda - Rua Gonçalves Dias 713 - 80240-340 Curitiba PR - Brasil.
CORREÇÃO. Duas correções são necessárias no artigo Rezende PA, Arruda WO. Aspectos genéticos da esclerose múltipla: II. Sistema HLA. Arq Neuropsiquiatr 1996; 54(3): 439-450. A primeira, na Figura 1 (página 441): onde consta "proteínas do comportamento" leia-se "proteínas do complemento". A segunda, no título da Tabela 2 (página 446): onde consta "de diversas rocedências", leia-se "de diversas procedências". Essas incorreções foram notadas por Patrícia Almeida de Rezende, a primeira autora do artigo, cuja cooperação o Editor agradece.