Mumps meningoencephalitis: an epidemiological approach

Leboreiro-Fernandez, Alfredo; Moura-Ribeiro, Maria Valeriana L; Leboreiro, Ivone Elisabete Ferreira; Sawan, Fahim Miguel; Ventura, Alessandra Ribeiro; Barbosa, Kellen Cristina Kamimura

doi:10.1590/S0004-282X1997000100003

Abstracts

The aim of this study was to analyse distribution of meningoencefalitis caused by mumps viras in children related to sex, age and seasonal influences. Thirty seven children were evaluated, ages ranging from 2 to 14 years. They were seen at Emergency Unit of Faculdade de Medicina do Triângulo Mineiro and at Hospital da Criança, in Uberaba-MG, Brazil, from March 1st 1991 to February 1st 1993 and they were hospitalized for about 5 days. Through a protocol findings were studied during hospitalization and clinical course stressing epidemiology, symptomatology, cerebrospinal fluid studies, electroencephalogram and cortical function analysis. Only epidemiological data were considered in the present study. Data analysis revealed male predominance, at a range from 5 to 9 years and great number of occurrences at the last quarter of the year.

mumps meningoencephalitis; neuroepidemiology; aseptic meningoencephalitis

O presente trabalho tem por objetivo, estudar a distribuição quanto ao sexo, idade e sazonalidade, em crianças com meningencefalite pelo vírus da caxumba. Foram avaliadas 37 crianças, com idades variando de 2 a 14 anos, atendidas no Pronto-Socorro do Hospital Escola da FMTM e do Hospital da Criança, MG, no período de 1-março-1991 a 1-fevereiro-1993 e hospitalizadas por período médio de 5 dias. Através de protocolo pré-elaborado foram estudados os achados obtidos por ocasião da internação e evolução, enfatizando-se a epidemiologia, sintomatologia, líquido cefalorraqueano, eletrencefalograma e função cortical. São considerados apenas os dados epidemiológicos, no presente estudo. A análise das informações pertinentes revela predomínio no sexo masculino, na faixa etária dos 5 aos 9 anos e maior número de casos no último trimestre do ano, correspondente à estação da primavera.

meningencefalite pelo vírus da caxumba; neuroepidemiologia; meningencefalite asséptica

Mumps meningoencephalitis: an epidemiological approach

Meningoencefalite pelo vírus da caxumba: abordagem epidemiológica

Alfredo Leboreiro-Fernandez^I; Maria Valeriana L Moura-Ribeiro^II; Ivone Elisabete Ferreira Leboreiro^I; Fahim Miguel Sawan^I; Alessandra Ribeiro Ventura^I; Kellen Cristina Kamimura Barbosa^I

^IFaculdade de Medicina do Triângulo Mineiro (FMTM), Uberaba, MG, Brasil

^IIFaculdade de Ciências Médicas, Universidade de Campinas, SP, Brasil

ABSTRACT

The aim of this study was to analyse distribution of meningoencefalitis caused by mumps viras in children related to sex, age and seasonal influences. Thirty seven children were evaluated, ages ranging from 2 to 14 years. They were seen at Emergency Unit of Faculdade de Medicina do Triângulo Mineiro and at Hospital da Criança, in Uberaba-MG, Brazil, from March 1st 1991 to February 1st 1993 and they were hospitalized for about 5 days. Through a protocol findings were studied during hospitalization and clinical course stressing epidemiology, symptomatology, cerebrospinal fluid studies, electroencephalogram and cortical function analysis. Only epidemiological data were considered in the present study. Data analysis revealed male predominance, at a range from 5 to 9 years and great number of occurrences at the last quarter of the year.

Key words: mumps meningoencephalitis, neuroepidemiology, aseptic meningoencephalitis.

RESUMO

O presente trabalho tem por objetivo, estudar a distribuição quanto ao sexo, idade e sazonalidade, em crianças com meningencefalite pelo vírus da caxumba. Foram avaliadas 37 crianças, com idades variando de 2 a 14 anos, atendidas no Pronto-Socorro do Hospital Escola da FMTM e do Hospital da Criança, MG, no período de 1-março-1991 a 1-fevereiro-1993 e hospitalizadas por período médio de 5 dias. Através de protocolo pré-elaborado foram estudados os achados obtidos por ocasião da internação e evolução, enfatizando-se a epidemiologia, sintomatologia, líquido cefalorraqueano, eletrencefalograma e função cortical. São considerados apenas os dados epidemiológicos, no presente estudo. A análise das informações pertinentes revela predomínio no sexo masculino, na faixa etária dos 5 aos 9 anos e maior número de casos no último trimestre do ano, correspondente à estação da primavera.

Palavras-chave: meningencefalite pelo vírus da caxumba, neuroepidemiologia, meningencefalite asséptica.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

ACKNOWLEDGEMENT

We are grateful to Professor Virmondes Rodrigues for helpful comments.

Aceite: 2-setembro-1996.

Este estudo faz parte da Dissertação de Mestrado do primeiro autor, apresentada à Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

Dr. Alfredo Leboreiro-Fernandez - Avenida Leopoldino de Oliveira 2733,9º andar - 38.015-000 Uberaba MG - Brasil.

1. Anderson RM, Crombie J A, Grenfell BT. The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunization. Epidem Inf 1987;99:65-84.
2. Azimi PH, Cramblett HG, Haynes RE. Mumps meningoencephalitis in children. JAMA 1969;207:509-512.
3. Bang HO, Bang J. Involvement of the central nervous system in mumps. Acta Med Scand 1943;113:487-505.
4. Brown JW, Kirkland HB, Hein GE. Central nervous system involvement during mumps. Am J Med Sci 1948; 215:434-441.
5. Chopin PW, Scheid A. The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses. Rev Infect Dis 1980;2:40-61.
6. Donald PR, Burger PJ, Becker WB. Mumps meningoencephalitis. S Afr Med J 1987;71:283-285.
7. Fishman RA. Composition of cerebrospinal fluid. In Fishman RA. Cerebrospinal fluid in diseases of the nervous system. Philadelphia: Saunders, 1980; 168-251.
8. Freeman R, Hambling MH. Serological studies on 40 cases of mumps virus infection. J Clin Pathol 1980;33:28-32.
9. Gallin JI. The compromised host. In Wyngaarden JB, Smith LH (eds). Cecil textbook of medicine. Igaku-Shoin: Saunders, 1985,1477-1485.
10. Johnson RT. Viral meningitis and encephalitis. In Wyngaarden JB, Smith LH (eds). Cecil textbook of medicine. Igaku-Shoin: Saunders, 1985:2122-2126.
11. Johnstone J A, Ross CAC, Dunn M. Meningitis and encephalitis associated with mumps infection: a 10-year survey. Arch Dis Child 1972;47:647-651.
12. Koskiniemi M, Donner M, Pettay O. Clinical appearance and outcome in mumps encephalitis in children. Acta Paediatr Scand 1983;72:603-609.
13. Levitt LP, Mahoney D, Casey HL, Bond JO. An epidemiologic and serologic study of mumps in families selected from a general population. In Annual Immunization Conference 6, Atlanta, 1969. Proceedings. Atlanta, 1969.
14. Levitt LP, Rich TA, Kinde SW, Lewis AL, Gates EH, Bond JO. Central nervous system mumps: a review of 64 cases. Neurology 1970;20:829-834.
15. Luttar SS, Zigler E. Vulnerability and competence: a review of research on resilience in childhood. Amer J Orthopsychiat 1991;61:6-22.
16. Marks MI. Mumps. In Braude AI (ed). Infections diseases and medical microbiology. Philadelphia: International Textbook of Medicine, 1986:776-782.
17. Mechanic D. The experience and reporting of common physical complaints. J Health Soc Behav 1980; 21:146-155.
18. Murray HGS, Field CMB, McLeod WJ. Mumps meningoencephalitis. BrMedJ 1960;1:1850-1853.
19. Richman DD. Paramyxoviruses. In Braunde AI (ed). Infections diseases and medical microbiology. Philadelphia: International Textbook of Medicine, 1986:514-520.
20. Silver TS, Todd JK. Hypoglycorachia in pediatric patients. Pediatrics 1976;58:67-71.
21. Sluzewski W. Aspects évolutifs des méningo-encéphalites ourliennes chez l'enfant: à propos de quarante-deux cas. Ann Pédiat 1985;32:233-235.
22. Spina-Franç a A. Líquido cefalorraqueano. In Tolosa APM, Canelas HM (eds). Propedêutica neurológica: temas essenciais. São Paulo: Sarvier, 1971.
23. Timo-Iaría C, Longo RH, Benini A. O líquido cefalorraqueano na meningite parotídica. Arq Neuropsiquiatr 1954; 12:259-263.
24. Wallgren A. Une nouvelle maladie infectieuse du système nerveux central? Acta Pxdiatr Scand 1925;4(Suppl): 158-182.
25. Widell S. On the cerebrospinal fluid in normal children and patients with acute abacterial meningo-encephalitis. Acta Pediatrics 1958;47(Suppl): 1-101.
26. Wilfert CM. Mumps meningoencephalitis with low cerebrospinal fluid glucose, prolonged pleocytosis and elevation of protein. N Engl J Med 1969;280:855-859.
27. Wilfert CM. Mumps. (Epidemic parotitis). In Wyngaarden JB, Smith LM (eds). Cecil textbook of medicine. Igaku-Shoin: Saunders, 1985:1712-1714.

Publication Dates

Publication in this collection
10 Nov 2010
Date of issue
1997

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Anderson RM, Crombie J A, Grenfell BT. The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunization. Epidem Inf 1987;99:65-84.

[2] 2. Azimi PH, Cramblett HG, Haynes RE. Mumps meningoencephalitis in children. JAMA 1969;207:509-512.

[3] 3. Bang HO, Bang J. Involvement of the central nervous system in mumps. Acta Med Scand 1943;113:487-505.

[4] 4. Brown JW, Kirkland HB, Hein GE. Central nervous system involvement during mumps. Am J Med Sci 1948; 215:434-441.

[5] 5. Chopin PW, Scheid A. The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses. Rev Infect Dis 1980;2:40-61.

[6] 6. Donald PR, Burger PJ, Becker WB. Mumps meningoencephalitis. S Afr Med J 1987;71:283-285.

[7] 7. Fishman RA. Composition of cerebrospinal fluid. In Fishman RA. Cerebrospinal fluid in diseases of the nervous system. Philadelphia: Saunders, 1980; 168-251.

[8] 8. Freeman R, Hambling MH. Serological studies on 40 cases of mumps virus infection. J Clin Pathol 1980;33:28-32.

[9] 9. Gallin JI. The compromised host. In Wyngaarden JB, Smith LH (eds). Cecil textbook of medicine. Igaku-Shoin: Saunders, 1985,1477-1485.

[10] 10. Johnson RT. Viral meningitis and encephalitis. In Wyngaarden JB, Smith LH (eds). Cecil textbook of medicine. Igaku-Shoin: Saunders, 1985:2122-2126.

[11] 11. Johnstone J A, Ross CAC, Dunn M. Meningitis and encephalitis associated with mumps infection: a 10-year survey. Arch Dis Child 1972;47:647-651.

[12] 12. Koskiniemi M, Donner M, Pettay O. Clinical appearance and outcome in mumps encephalitis in children. Acta Paediatr Scand 1983;72:603-609.

[13] 13. Levitt LP, Mahoney D, Casey HL, Bond JO. An epidemiologic and serologic study of mumps in families selected from a general population. In Annual Immunization Conference 6, Atlanta, 1969. Proceedings. Atlanta, 1969.

[14] 14. Levitt LP, Rich TA, Kinde SW, Lewis AL, Gates EH, Bond JO. Central nervous system mumps: a review of 64 cases. Neurology 1970;20:829-834.

[15] 15. Luttar SS, Zigler E. Vulnerability and competence: a review of research on resilience in childhood. Amer J Orthopsychiat 1991;61:6-22.

[16] 16. Marks MI. Mumps. In Braude AI (ed). Infections diseases and medical microbiology. Philadelphia: International Textbook of Medicine, 1986:776-782.

[17] 17. Mechanic D. The experience and reporting of common physical complaints. J Health Soc Behav 1980; 21:146-155.

[18] 18. Murray HGS, Field CMB, McLeod WJ. Mumps meningoencephalitis. BrMedJ 1960;1:1850-1853.

[19] 19. Richman DD. Paramyxoviruses. In Braunde AI (ed). Infections diseases and medical microbiology. Philadelphia: International Textbook of Medicine, 1986:514-520.

[20] 20. Silver TS, Todd JK. Hypoglycorachia in pediatric patients. Pediatrics 1976;58:67-71.

[21] 21. Sluzewski W. Aspects évolutifs des méningo-encéphalites ourliennes chez l'enfant: à propos de quarante-deux cas. Ann Pédiat 1985;32:233-235.

[22] 22. Spina-Franç a A. Líquido cefalorraqueano. In Tolosa APM, Canelas HM (eds). Propedêutica neurológica: temas essenciais. São Paulo: Sarvier, 1971.

[23] 23. Timo-Iaría C, Longo RH, Benini A. O líquido cefalorraqueano na meningite parotídica. Arq Neuropsiquiatr 1954; 12:259-263.

[24] 24. Wallgren A. Une nouvelle maladie infectieuse du système nerveux central? Acta Pxdiatr Scand 1925;4(Suppl): 158-182.

[25] 25. Widell S. On the cerebrospinal fluid in normal children and patients with acute abacterial meningo-encephalitis. Acta Pediatrics 1958;47(Suppl): 1-101.

[26] 26. Wilfert CM. Mumps meningoencephalitis with low cerebrospinal fluid glucose, prolonged pleocytosis and elevation of protein. N Engl J Med 1969;280:855-859.

[27] 27. Wilfert CM. Mumps. (Epidemic parotitis). In Wyngaarden JB, Smith LM (eds). Cecil textbook of medicine. Igaku-Shoin: Saunders, 1985:1712-1714.