Adult T-cell leukemia-lymphoma in a patient with HTLV-I/II associated myelopathy

Freitas, Virgínia; Gomes, Irenio; Bittencourt, Achilea; Fernandes, Dilson; Melo, Ailton

doi:10.1590/S0004-282X1997000200024

Abstracts

Chronic myelopathy associated with T-lymphotropic virus type I (HAM) has been described as an endemic disease in several areas of the world, meanwhile there are few papers describing the association between HAM and adult T cell leukemia-lymphoma. We report the case of a man that, after four years of progressive spastic paraparesis and neurogenic bladder, developed a clinical picture of a lymphoproliferative disorder characterized by dermal and systemic envolvement, mimicking mycosis fungoides/Sézary syndrome.

HTLV-I; HAM; TSP; ATLL; myelopathy; encephalomyeloneuropathy

Apesar da infecção pelo HTLV-I ser endêmica em várias regiões do mundo, poucos são os relatos da associação entre leucemia-linfoma de células T do adulto (ATLL) e encefalomieloneuropatia pelo HTLV-I. No presente artigo é descrito um paciente que no curso do comprometimento neurológico pelo HTLV-I desenvolveu quadro de leucemia com infiltração de tecido dérmico semelhante ao encontrado na micose fungóide/síndrome de Sézary.

HTLV-I; TSP; HAM; ATLL; mielopatia; encefalomieloneuropatia

Adult T-cell leukemia-lymphoma in a patient with HTLV-I/II associated myelopathy

Leucemia - linfoma de células T do adulto em um paciente com mielopatia associada a HTLV-I/II

Virgínia Freitas; Irenio Gomes; Achilea Bittencourt; Dilson Fernandes; Ailton Melo

Federal University of Bahia (UFBA)

ABSTRACT

Chronic myelopathy associated with T-lymphotropic virus type I (HAM) has been described as an endemic disease in several areas of the world, meanwhile there are few papers describing the association between HAM and adult T cell leukemia-lymphoma. We report the case of a man that, after four years of progressive spastic paraparesis and neurogenic bladder, developed a clinical picture of a lymphoproliferative disorder characterized by dermal and systemic envolvement, mimicking mycosis fungoides/Sézary syndrome.

Key words: HTLV-I, HAM, TSP, ATLL, myelopathy, encephalomyeloneuropathy.

RESUMO

Apesar da infecção pelo HTLV-I ser endêmica em várias regiões do mundo, poucos são os relatos da associação entre leucemia-linfoma de células T do adulto (ATLL) e encefalomieloneuropatia pelo HTLV-I. No presente artigo é descrito um paciente que no curso do comprometimento neurológico pelo HTLV-I desenvolveu quadro de leucemia com infiltração de tecido dérmico semelhante ao encontrado na micose fungóide/síndrome de Sézary.

Palavras-chave: HTLV-I, TSP, HAM, ATLL, mielopatia, encefalomieloneuropatia.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 22-fevereiro-1997.

Dr. Ailton Melo - Faculdade de Medicina UFBA - Av. Reitor Miguel Calmon s/n - 40110-100 Salvador BA - Brasil.

1. Fine RM. HTLV-I a new human retrovirus associated with cutaneous T-cell lymphoma (mycosis fungoides). Int J Dermatol 1988;27:473-474.
2. Gessain A, Gout O.Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I). Ann Intern Med 1992; 117:933-946.
3. Kawai H, Nishida Y, Takagi M, Nakamura K, Masuda K, Saito S, Shirakami A. HTLV-I associated myelopathy with adult T-cell leukemia. Neurology 1989:39:1129-1131.
4. Lennert K, Feller AC. Non Hodgkin's lymphomas. Berlin: Springer Verlag, 1992.
5. Mattos K, Queiroz C, Peçanha-Martins AC, Publio L, Vinhas V, Melo A. Lymphocyte alveolitis in HAM/TSP patients. Arq Neuropsiquiatr 1993,51:134-136.
6. Melo A, Gomes I, Mattos K. Mielopatias por HTLV-I na cidade de Salvador, Bahia. Arq Neuropsiquiatr 1994;52:320-325.
7. Pancake B A, Zucker-Franklin D. The difficulty of detecting HTLV-I proviral sequences in patients with mycosis fungoides. J AIDS 1996;13:314-319.
8. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T-lymphotropic virus associated disease. J Clin Invest 1995;95:547-554.
9. Turbitt ML, Mackic RM. P19 antigen in skin and lymph nodes of patient with advanced mycosis fungoides. Lancet 1985;2:945
10. Whittaker SJ; Luzzatto L. HTLV-I provirus and mycosis fungoides. Science 1993;259:1470
11. Yasui C, Fukaya T, Koizumi H, Kobayashi H, Ohkawara A. HTLV-I associated myelopathy in a patient with adult T-cell leukemia. J Acad Derm 1991 ;24:633-637.

Publication Dates

Publication in this collection
10 Nov 2010
Date of issue
June 1997

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Fine RM. HTLV-I a new human retrovirus associated with cutaneous T-cell lymphoma (mycosis fungoides). Int J Dermatol 1988;27:473-474.

[2] 2. Gessain A, Gout O.Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I). Ann Intern Med 1992; 117:933-946.

[3] 3. Kawai H, Nishida Y, Takagi M, Nakamura K, Masuda K, Saito S, Shirakami A. HTLV-I associated myelopathy with adult T-cell leukemia. Neurology 1989:39:1129-1131.

[4] 4. Lennert K, Feller AC. Non Hodgkin's lymphomas. Berlin: Springer Verlag, 1992.

[5] 5. Mattos K, Queiroz C, Peçanha-Martins AC, Publio L, Vinhas V, Melo A. Lymphocyte alveolitis in HAM/TSP patients. Arq Neuropsiquiatr 1993,51:134-136.

[6] 6. Melo A, Gomes I, Mattos K. Mielopatias por HTLV-I na cidade de Salvador, Bahia. Arq Neuropsiquiatr 1994;52:320-325.

[7] 7. Pancake B A, Zucker-Franklin D. The difficulty of detecting HTLV-I proviral sequences in patients with mycosis fungoides. J AIDS 1996;13:314-319.

[8] 8. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T-lymphotropic virus associated disease. J Clin Invest 1995;95:547-554.

[9] 9. Turbitt ML, Mackic RM. P19 antigen in skin and lymph nodes of patient with advanced mycosis fungoides. Lancet 1985;2:945

[10] 10. Whittaker SJ; Luzzatto L. HTLV-I provirus and mycosis fungoides. Science 1993;259:1470

[11] 11. Yasui C, Fukaya T, Koizumi H, Kobayashi H, Ohkawara A. HTLV-I associated myelopathy in a patient with adult T-cell leukemia. J Acad Derm 1991 ;24:633-637.