Print version ISSN 0004-282X
Arq. Neuro-Psiquiatr. vol.67 no.1 São Paulo Mar. 2009
A distal AICA aneurysm
Aneurisma distal da AICA
Eberval Gadelha FigueiredoI; Wellingson Silva PaivaII; Manoel Jacobsen TeixeiraIII
IMD, PhD, Supervisor, Division of Neurological Surgery, University of São Paulo School of Medicine, São Paulo SP, Brazil
IIMD, Resident, Division of Neurological Surgery, University of São Paulo School of Medicine, São Paulo SP, Brazil
IIIMD, PhD, Director and Chairman, Division of Neurological Surgery, University of São Paulo School of Medicine, São Paulo SP, Brazil
Aneurysms of the posterior fossa have been reported to account for 8 to 12% of all intracranial aneurysms1-3. Among these aneurysms, those of the distal AICA (anterior inferior cerebellar artery) are exceedingly rare, fewer than 100 cases have been reported, with a reported incidence of 0.10.5%4. Of the major arteries of the posterior fossa, the AICA is the least likely to harbor an aneurysm5. In Locksley's review of the first cooperative aneurysm study6, only two cases of AICA aneurysms were found among 7933 lesions. Schwartz7 reported the first surgically treated case of an AICA aneurysm in 1948. Since then few cases of distal AICA aneurysms have been reported.
We describe one case of distal AICA aneurysms highlighting diagnostic and therapeutic nuances.
A female, 45 years old, was brought to the emergency room from an outlying hospital where she had been admitted after suffering a sudden onset of severe headache, nausea, and vomiting. On admission, she was alert and had no neurologic focal deficits. The patient's condition was categorized as Grade 1 (Hunt-Hess). A computed tomography (CT) scan demonstrated a Fischer grade IV SAH with blood sediment within the fourth ventricle (Fig 1). Four-vessel digital subtraction angiography revealed a 9 mm in diameter saccular aneurysm located at the meatal loop of AICA (Fig 2). Wash out of the contrast medium was markedly delayed suggesting that the arterial blood flow was slow in the aneurysm sac (Fig 2).
A conventional retrosigmoid approach was carried out. At surgery, a distal AICA aneurysm was seen posteriorly to the seventh and eighth cranial nerves, causing displacement of the rootlets of the IX cranial nerve (Fig 3). The aneurysm sac presented very tiny wall, resembling a pseudoaneurysm, and no aneurysm neck was identified (Figs 3 and 4). The labyrinthine artery was individualized (Figs 3 and 4) and the aneurysm was trapped using two aneurysm clips (Fig 4). Due to the intimate relationships with the rootlets of the IX cranial nerve, the aneurysm sac was not incised precluding a histopathologic diagnosis of a pseudoaneurysm. Postoperatively, the patient was neurologically intact with no deficits either in the hearing or labyrinthine function.
She has consented with this publication.
In a recent literature review, it was found that 81 patients had 84 peripheral AICA aneurysms, including three patients with multiple distal AICA aneurysms8-10. Peripheral AICA aneurysms occurred predominantly in women (51 women, 21 men, 10 sex unknown); patient ages ranged from 1781 years (mean 48.2 years), with 76.2% of aneurysms located in the meatal segment of the AICA9.
The anatomy of the AICA is highly variable11-14. Typically, the artery arises from the junction between the middle and lower thirds of the basilar artery, courses along the pons and the middle cerebellar peduncle (to which it gives a few perforating branches), then bifurcates into two major branches, called the (rostro) lateral branch and the (caudo) medial branch. The rostrolateral branch courses close to the seventh and eighth cranial nerve complex and gives off the labyrinthine, or internal auditory artery. It is at this point that most peripheral AICA aneurysms are located 5,9,14,15. The caudomedial branch, in which aneurysms are seen only rarely, courses medially close to the pons, to which it sends a few perforators, and terminates in cerebellar branches. Patients with these aneurysms may present acutely with SAH or with symptoms of a mass lesion in the cerebello-pontine angle (CPA), including hearing loss, vertigo, tinnitus, facial weakness, diplopia, ataxia, or altered facial sensation.
The overall management of distal AICA aneurysms includes wrapping, proximal occlusion, trapping, intravascular embolization with coils, and direct surgical clipping. In a review of the literature, no single intervention proved more successful than any other in reversing preoperative deficits or preventing postoperative deterioration in the function of cranial nerves VII and VIII. The limited available information suggests a very low incidence of ischemic complications related to trapping distal AICA aneurysms close to the IAC (internal auditory canal), particularly if seventh and eighth cranial nerve dysfunction is present preoperatively. However, the literature on distal AICA aneurysms supports the notion that location of the lesion near the IAC is a negative prognostic factor for postoperative seventh and eighth cranial nerve function.
The most common treatment for distal AICA aneurysms is either clipping or trapping. Trapping is usually well tolerated; there are few reports of increased postoperative neurologic deficits. However, vessel repair or bypass should be considered in selected cases, yet it would be a difficult technical exercise in this location with a vessel segment of this diameter14. Some authors express concern that ligation or endovascular occlusion of the AICA may lead to ischemia by retrograde thrombosis of the trunk of AICA, resulting in impaired blood supply to the lateral middle and lower third of the pons and lateral upper third of the medulla10. Therefore, special attention should be exerted to identify branches of the AICA and their anastomoses with the SCA and PICA8.
Our aneurysm presented features of a pseudoaneurysm, such as delayed wash out and low flow, absence of a well defined neck and tiny walls. However, as a histopathologic examination was not possible, the authors may not draw considerations in this concern. Furthermore, other cases of distal AICA aneurysms with delayed wash out have been reported.
In conclusion, since the literature on distal AICA aneurysms is scarce, it is difficult to create guidelines for management based on so few cases. Our general approach is to select microsurgical intervention as a first choice, depending on the aneurysm's location, size, and configuration, as well as the patient's overall clinical condition. Currently, only microsurgical intervention has the potential to permanently obliterate these distal AICA aneurysms while preserving the parent artery.
1. Duvoisin RC, Yahr MD. Posterior fossa aneurysms. Neurology 1965;15: 231-241. [ Links ]
2. McDonald CA, Korb M. Intracranial aneurysms. Arch Neurol Psych 1939;42:298-328. [ Links ]
3. Weibel J, Fields WS, Campos RJ. Aneurysms of the posterior cervicocranial circulation: clinical and angiographic considerations. J Neurosurg 1967;26:223-234. [ Links ]
4. Kamano S, Kirino T, Mizuno S. Intrameatal aneurysm. Neurochirurugia 1986;29:28-30. [ Links ]
5. Mizushima H, Kobayashi N, Yoshiharu S, et al. Aneurysm of the distal anterior inferior cerebellar artery at the medial branch: a case report and review of the literature. Surg Neurol 1999;52:137-142. [ Links ]
6. Locksley HB. Natural history of subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations: based on 6368 cases in the cooperative study. J Neurosurg 1966;25:219-239. [ Links ]
7. Schwartz HG. Arterial aneurysm of the posterior fossa. J Neurosurg 1948;5:312-316. [ Links ]
8. Andaluz N, Pensak ML, Zuccarello M. Multiple, peripheral aneurysms of the anterior inferior cerebellar artery. Acta Neurochir (Wien) 2005;147:419-422 [ Links ]
9. Kyoshima K, Matsuda M, Handa J. Cerebral aneurysm of the distal anterior inferior cerebellar artery: case report. Nippon Geka Hokan 1995;64:139-145. [ Links ]
10. Nishimoto A, Fujimoto S, Tsuchimoto S, Matsumoto Y, Tabuchi K,Higashi T. Anterior inferior cerebellar artery aneurysm: report of three cases. J Neurosurg 1983;59:697-702. [ Links ]
11. Woischneck D, Hussein S. The anterior inferior cerebellar artery (AICA): clinical and radiological significance. Neurosurg Rev 1991;14:293-295. [ Links ]
12. Figueiredo EG, Zabramski JM, Deshmukh P, Crawford NR, Preul MC, Spetzler RF. Anatomical and quantitative description of the transcavernous approach to interpeduncular and prepontine cisterns: technical note. J Neurosurg 2006;104:957-964. [ Links ]
13. Figueiredo EG, Zabramski JM, Deshmukh P, Crawford NR, Spetzler RF, Preul MC. Comparative analysis of anterior petrosectomy and transcavernous approaches to retrosellar and upper clival basilar artery aneurysms. Neurosurgery 2006;58(Suppl 1):S13-S21. [ Links ]
14. Gonzalez LF, Alexander MJ, McDougall CG, Spetzler RF. Anteroinferior cerebellar artery aneurysms: surgical approaches and outcomes. A review of 34 cases. Neurosurgery 2004;55:1025-1035. [ Links ]
15. Siwanuwatn R, Deshmukh P, Figueiredo EG, Crawford NR, Spetzler RF, Preul MC. Quantitative analysis of the working area and angle of attack for the retrosigmoid, combined petrosal, and transcochlear approaches to the petroclival region. J Neurosurg 2006;104:137-142. [ Links ]
Received 31 January 2008, received in final form 12 November 2008. Accepted 26 November 2008.
Dr. Eberval G. Figueiredo Rua Oscar Freire 1456 / 34 - 05409-010 São Paulo SP - Brasil. E-mail: firstname.lastname@example.org