African histoplasmosis: report of the first case in Brazil and treatment with itraconazole

Histoplasmose africana: relato do primeiro caso no Brasil e tratado pelo itraconazol

CASE REPORT

African histoplasmosis. Report of the first case in Brazil and treatment with itraconazole(¹)

Histoplasmose africana. Relato do primeiro caso no Brasil e tratado pelo itraconazol

Leonardo Abrucio Neto^I; Maria Denise Fonseca Takahashi^II; Alberto Salebian^III; Luiz Carlos Cucé^IV

^IResident of "Departamento de Dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)"

^IIStaff Physician of "Departamento de Dermatologia do HCFMUSP"

^IIIMycologist of "Instituto de Medicina Tropical de São Paulo" and of "Departamento de Dermatologia do HCFMUSP"

^IVAssociate Professor of "Departamento de Dermatologia do HCFMUSP"

^{Address for Correspondence}

SUMMARY

We report the first case of African histoplasmosis diagnosed in Brazil. The patient was an immigrant from Angola who had come to Brazil six months after the appearance of the skin lesion. The skin of the right retroauricular area was the only site of involvement. The diagnosis was established by direct mycologic examination, culture and by histopathologic examination of the lesion. The patient was successfully treated with Itraconazole 100mg a day for 52 days. No recurrent skin lesions were observed during the ten month follow-up period.

Key words: African Histoplasmosis; Histoplasma capsulatum var. duboisii; Itraconazole.

RESUMO

Relata-se o primeiro caso de histoplasmose africana diagnosticado em nosso meio, em indivíduo angolano que imigrou para o Brasil seis meses após o início das lesões. Quadro clínico de forma localizada exclusivamente na pele na região retro auricular direita. O diagnóstico foi estabelecido através do exame micológico direto, cultura e exame anátomo-patológico. Houve sucesso terapêutico com a administração de itraconazol, na dose de 100mg/dia durante 52 dias. Não houve recidiva do quadro cutâneo no seguimento clínico do doente após 10 meses de interrupção do tratamento.

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Recebido para publicação em 17/09/1992

Aceito para publicação em 23/12/1992

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Address for Correspondence:

Dr. Leonardo Abrucio Neto

Departamento de Dermatologia, Hospital das Clínicas da FMUSP

Av. Dr. Enéas de Carvalho Aguiar, 255 - 3º andar

05403-000 São Paulo - SP, Brasil

(1

) This investigation was performed at "Departamento de Dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo". Chairman: Prof. Evandro A. Rivitti.

Publication Dates

• Publication in this collection
  20 July 2006
• Date of issue
  June 1993

History

• Accepted
  23 Dec 1992
• Received
  17 Sept 1992