Mucosal leishmaniasis due to Leishmania (Viannia) braziliensis L(V)b in Três Braços, Bahia-Brazil

Marsden, Philip Davis

doi:10.1590/S0037-86821994000200007

Abstracts

Brazilian mucosal leshmaniasis is briefly reviewed, emphasis being given to recent advances clinical management. Patients continue to occupy much hospital bed space and in some cases are notoriously difficult to treat. Indefinite follow up is recommended. Many aspects of the aetiology remain mysterious although Leishmania (Viannia) braziliensis is the most common organism isolated. Perspectives for a more effective treatment, oral and cheap, are still remote.

Mucosal leishmaniasis; Leishmania (Viannia) braziliensis; CUnicalmanagement; Três Braços; Brazil

Neste trabalho, é feita uma breve revisão da leishmaniose mucosa existente no Brasil enfatizando os recentes avanços no tratamento clinico. Os pacientes frequentemente ocupam os leitos hospitalares e alguns casos são notoriamente difíceis de tratar. Recomenda-se um acompanhamento por tempo indefinido. Embora a Leishmania (Viannia) braziliensis seja o microorganismo mais comumente isolado, muitos aspectos da etiologia permanecem obscuros. As perpectivas de um tratamento oral e barato são ainda remotas.

Leishmaniose mucosa; Leishmania (Viannia) braziliensis; Tratamento cUnico; Três Braços; Brasil

ARTICLES

Mucosal leishmaniasis due to Leishmania (Viannia) braziliensis L(V)b in Três Braços, Bahia-Brazil

Philip Davis Marsden

^{Adress to correspondence} Adress to correspondence: Prof. Philip Davis Marsden. Núcleo de Medicina Tropical e Nutrição/UnB. Caixa Postal 04-671 70919-970 Brasilia, DF, Brasil.

ABSTRACT

Brazilian mucosal leshmaniasis is briefly reviewed, emphasis being given to recent advances clinical management. Patients continue to occupy much hospital bed space and in some cases are notoriously difficult to treat. Indefinite follow up is recommended. Many aspects of the aetiology remain mysterious although Leishmania (Viannia) braziliensis is the most common organism isolated. Perspectives for a more effective treatment, oral and cheap, are still remote.

Keywords: Mucosal leishmaniasis. Leishmania (Viannia) braziliensis. CUnicalmanagement. Três Braços, Brazil.

RESUMO

Neste trabalho, é feita uma breve revisão da leishmaniose mucosa existente no Brasil enfatizando os recentes avanços no tratamento clinico. Os pacientes frequentemente ocupam os leitos hospitalares e alguns casos são notoriamente difíceis de tratar. Recomenda-se um acompanhamento por tempo indefinido. Embora a Leishmania (Viannia) braziliensis seja o microorganismo mais comumente isolado, muitos aspectos da etiologia permanecem obscuros. As perpectivas de um tratamento oral e barato são ainda remotas.

Palavras-chave: Leishmaniose mucosa. Leishmania (Viannia) braziliensis. Tratamento cUnico. Três Braços, Brasil.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Recebido para publicação em 22/10/93.

Núcleo de Medicina Tropical e Nutrição da Universidade de Brasília, Brasília, DF.

Supported by NIH grant AI 16282.

1. Berman JD. Chemotherapy for leishmaniasis: Biochemical mechanisms, clinical efficacy, and future strategies. Reviews of Infectious Disease 10:560-565, 1988.
2. Bryceson ADM. Therapy in Man. In: Peters W, Kendrick RK (eds). The Leishmaniases in Biology and Medicine. Academic Press, London, vol 2, p.847-907, 1987.
3. Burkitt D. Determining the climatic limitations of a children's cancer common in Africa. British Medical Journal 2:1019-1923, 1962.
4. Carini A. Leishmaniose de la muqueuse rhino- bucca-pharyngée. Bulletin de la Societé Pathologique Exotique 4:289-291, 1911.
5. Chunge CN, Owale J, Pamba HO, Donno L. Treatment of visceral in Kenya by aminosidine alone or combined with sodium stibogluconate. Transactions of the Royal Society of Tropical Medicine and Hygiene 84:221-225, 1990.
6. Costa MLJ, Vale KC, França F, Saldanha ACR, Silva JO, Lago EL, Marsden PD, Magalhães AV, Silva CMP, Netto EA, Galvão CES. Cura espontânea da leishmaniose causada por Leishmania (Viannia) braziliensis em lesões cutâneas. Revista da Sociedade Brasileira de Medicina Tropical 23:205-208,1990.
7. Cuba CA, Miles MA, Vexenat A, Barker DC, Mc Mahon Pratt D, Butcher J, Barreto AC, Marsden PD. A focus of mucocutaneous leishmaniasis in Três Braços, Bahia-Brazil: charaeterisatien and identification of leishmanial stocks isolated iram mm and dogs, Trangaetieng of the Royal Soeiety of Tropical Medieine and Hygiene 79:500-507,1985.
8. Escomel E. La espundia. Bulletin de la Societé de Pathologique Exotique 4:489-492, 1911.
9. Fauci AS, Wolff SM. Radiation therapy of midline granuloma. Annals of Internal Medicine 84:140- 147, 1976.
10. França F, Lago EL, Tada MS, Costa JML, Vale K, Oliveira J, Costa MA, Osaki M, CheeverL, Netto EM, Barreto AC, Johson WD, Marsden PD, An outbreak of human Leishmania (Viannia) braziliensis infection. Memdrias do Instituto Oswaldo Cruz 86:169-174, 1991.
11. Grimaldi G, Tesh AB, McMahon Pratt D. Areview of the geographic distribution and epidemiology of leishmaniasis in the New World. The American Journal of Tropical Medicine and Hygiene 41:689- 725, 1989.
12. HamanLM. Ensaio terapêutico com quatro dosagens de antimonial no tratamento de leishmaniose cutânea causada por Leishmania (Viannia) braziliensis Tese de mestrado, Universidade de Brasília, Brasília DF, 1989.
13. Jackson M. The boy David. The Story of a Fight to Save a Child's Face, 150p, British Broadcasting Corporation, London, 1985.
14. Jones TC, Johnson WD, Barreto AC, Lago E, Badaró R, Cerf B, Reed SG, Netto EM, Tada MS, França F, Wiese K, Golightly L, Fikrig E, Costa JML, Cuba CC, Marsden PD. Epidemiology of American cutaneous leishmaniasis dueto Leishmania braziliensis braziliensis. Journal of Infectious Disease 156:73-83, 1987.
15. Marsden PD. Pentavalent antimonials: old drugs for new diseases. Revista da Sociedade Brasileira de Medicina Tropical 18:187-198, 1985.
16. Marsden PD. Mucosal leishmaniasis (Espundia/ Escomel, 1911). Transactions of the Royal Society of Tropical Medicine and Hygiene 80:859-876, 1986.
17. Marsden PD, Badaró R, Netto EM, Casler JD. Spontaneous clinical resolution without specific treatment in mucosal leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 85:221, 1991.
18. Marsden PD, Sampaio RNR, Carvalho EM, Veiga JPI, Costa JML, Llanos-Cuentas EA. Highcontinous antimony therapy in two patients with unresponsive mucosal leishmaniasis, The American Journal of Tropical Medicine and Hygiene 34:710-713,1985.
19. Nette EM. Available de procedimentes imunodiagnósticos numa área endêmica de leishmaniosetegumentar na Bahia. Tese de mestrado, Universidade Federal da Bahia, Salvador, BA, Brasil, 1990.
20. Netto EM, Minden PD, Liftes-Cuentas SA, Costa JML, Cuba CC, Barreto AC, Badaró R, Johson WD, Jones TC, Long term follow up of patientis with Leishmania (Viannia) braziliensis infection and treated with glucantime. Transactions of the Royal Society of Tropical Medicine and Hygiene 84:367- 370, 1990.
21. Olliaro PL, Bryceson ADM, Practical progress and new drugs for changing patterns of leismaniasis. Parasitology Today 9:323-328, 1993.
22. Pessoa SB, Barreto MP. Leishmaniose tegumentar americana. Imprensa Nacional, Rio de Janeiro, 1948.
23. Ridley DS, Magalhães AV, Marsden PD. Histolo gical analysis and pathogenesis of mucocutaneous leishmaniasis. Journal of Pathology 159:293-299, 1989.
24. Ryan L, Vexenat A, Marsden PD, Lainson R, Shaw JJ. The importance of rapid diagnosis of new cases of cutaneous leishmaniasis in pin pointing the sandfly vector. Transactions ofthe Royal Society ofTropical Medicine and Hygiene 84:786, 1990.
25. Sampaio RNR, Soares KPS, Rosa AC, Netto EM, Magalhães AV, Marsden PD. Tratamento com pentamidina de seis casos de forma mucosa de leishmaniose tegumentar. Anais Brasileiros de Dermatologia 63:439-442, 1986.
26. Tsokos M, Fauci AS, Costa J. Idiopathic midline destructive disease (IMDD). American Journal of Clinical Pathology 77-.162-168, 1982.
27. Vexenat A, Rosa C, Cuba CC, Marsden PD. Recovery of Leishmania (Viannia) braziliensis from hepatic aspirates of the black plumed marmoset Callithrix penicillata Transactions of the Royal Society ofTropical Medicine and Hygiene 85:596, 1991.
28. Vieira JB, Laçerda MM, Marsden PD. National reporting of leishmaniasis: the Brazilian experience. Parasitology Today 6:339-340, 1990.
29. Zajtchuck JT, Casier JD, Netto EM, Grogl M, Neafie RC, Hessel CR, Magalhães AV, Marsden PD. Mucosal leishmaniasis in Brazil. Laryngoscope 99:925-939, 1989.

Adress to correspondence:

Prof. Philip Davis Marsden.

Núcleo de Medicina Tropical e Nutrição/UnB.

Caixa Postal 04-671

70919-970

Brasilia, DF, Brasil.

Publication Dates

Publication in this collection
10 Apr 2013
Date of issue
June 1994

History

Received
22 Oct 1993
Accepted
22 Oct 1993

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Berman JD. Chemotherapy for leishmaniasis: Biochemical mechanisms, clinical efficacy, and future strategies. Reviews of Infectious Disease 10:560-565, 1988.

[2] 2. Bryceson ADM. Therapy in Man. In: Peters W, Kendrick RK (eds). The Leishmaniases in Biology and Medicine. Academic Press, London, vol 2, p.847-907, 1987.

[3] 3. Burkitt D. Determining the climatic limitations of a children's cancer common in Africa. British Medical Journal 2:1019-1923, 1962.

[4] 4. Carini A. Leishmaniose de la muqueuse rhino- bucca-pharyngée. Bulletin de la Societé Pathologique Exotique 4:289-291, 1911.

[5] 5. Chunge CN, Owale J, Pamba HO, Donno L. Treatment of visceral in Kenya by aminosidine alone or combined with sodium stibogluconate. Transactions of the Royal Society of Tropical Medicine and Hygiene 84:221-225, 1990.

[6] 6. Costa MLJ, Vale KC, França F, Saldanha ACR, Silva JO, Lago EL, Marsden PD, Magalhães AV, Silva CMP, Netto EA, Galvão CES. Cura espontânea da leishmaniose causada por Leishmania (Viannia) braziliensis em lesões cutâneas. Revista da Sociedade Brasileira de Medicina Tropical 23:205-208,1990.

[7] 7. Cuba CA, Miles MA, Vexenat A, Barker DC, Mc Mahon Pratt D, Butcher J, Barreto AC, Marsden PD. A focus of mucocutaneous leishmaniasis in Três Braços, Bahia-Brazil: charaeterisatien and identification of leishmanial stocks isolated iram mm and dogs, Trangaetieng of the Royal Soeiety of Tropical Medieine and Hygiene 79:500-507,1985.

[8] 8. Escomel E. La espundia. Bulletin de la Societé de Pathologique Exotique 4:489-492, 1911.

[9] 9. Fauci AS, Wolff SM. Radiation therapy of midline granuloma. Annals of Internal Medicine 84:140- 147, 1976.

[10] 10. França F, Lago EL, Tada MS, Costa JML, Vale K, Oliveira J, Costa MA, Osaki M, CheeverL, Netto EM, Barreto AC, Johson WD, Marsden PD, An outbreak of human Leishmania (Viannia) braziliensis infection. Memdrias do Instituto Oswaldo Cruz 86:169-174, 1991.

[11] 11. Grimaldi G, Tesh AB, McMahon Pratt D. Areview of the geographic distribution and epidemiology of leishmaniasis in the New World. The American Journal of Tropical Medicine and Hygiene 41:689- 725, 1989.

[12] 12. HamanLM. Ensaio terapêutico com quatro dosagens de antimonial no tratamento de leishmaniose cutânea causada por Leishmania (Viannia) braziliensis Tese de mestrado, Universidade de Brasília, Brasília DF, 1989.

[13] 13. Jackson M. The boy David. The Story of a Fight to Save a Child's Face, 150p, British Broadcasting Corporation, London, 1985.

[14] 14. Jones TC, Johnson WD, Barreto AC, Lago E, Badaró R, Cerf B, Reed SG, Netto EM, Tada MS, França F, Wiese K, Golightly L, Fikrig E, Costa JML, Cuba CC, Marsden PD. Epidemiology of American cutaneous leishmaniasis dueto Leishmania braziliensis braziliensis. Journal of Infectious Disease 156:73-83, 1987.

[15] 15. Marsden PD. Pentavalent antimonials: old drugs for new diseases. Revista da Sociedade Brasileira de Medicina Tropical 18:187-198, 1985.

[16] 16. Marsden PD. Mucosal leishmaniasis (Espundia/ Escomel, 1911). Transactions of the Royal Society of Tropical Medicine and Hygiene 80:859-876, 1986.

[17] 17. Marsden PD, Badaró R, Netto EM, Casler JD. Spontaneous clinical resolution without specific treatment in mucosal leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 85:221, 1991.

[18] 18. Marsden PD, Sampaio RNR, Carvalho EM, Veiga JPI, Costa JML, Llanos-Cuentas EA. Highcontinous antimony therapy in two patients with unresponsive mucosal leishmaniasis, The American Journal of Tropical Medicine and Hygiene 34:710-713,1985.

[19] 19. Nette EM. Available de procedimentes imunodiagnósticos numa área endêmica de leishmaniosetegumentar na Bahia. Tese de mestrado, Universidade Federal da Bahia, Salvador, BA, Brasil, 1990.

[20] 20. Netto EM, Minden PD, Liftes-Cuentas SA, Costa JML, Cuba CC, Barreto AC, Badaró R, Johson WD, Jones TC, Long term follow up of patientis with Leishmania (Viannia) braziliensis infection and treated with glucantime. Transactions of the Royal Society of Tropical Medicine and Hygiene 84:367- 370, 1990.

[21] 21. Olliaro PL, Bryceson ADM, Practical progress and new drugs for changing patterns of leismaniasis. Parasitology Today 9:323-328, 1993.

[22] 22. Pessoa SB, Barreto MP. Leishmaniose tegumentar americana. Imprensa Nacional, Rio de Janeiro, 1948.

[23] 23. Ridley DS, Magalhães AV, Marsden PD. Histolo gical analysis and pathogenesis of mucocutaneous leishmaniasis. Journal of Pathology 159:293-299, 1989.

[24] 24. Ryan L, Vexenat A, Marsden PD, Lainson R, Shaw JJ. The importance of rapid diagnosis of new cases of cutaneous leishmaniasis in pin pointing the sandfly vector. Transactions ofthe Royal Society ofTropical Medicine and Hygiene 84:786, 1990.

[25] 25. Sampaio RNR, Soares KPS, Rosa AC, Netto EM, Magalhães AV, Marsden PD. Tratamento com pentamidina de seis casos de forma mucosa de leishmaniose tegumentar. Anais Brasileiros de Dermatologia 63:439-442, 1986.

[26] 26. Tsokos M, Fauci AS, Costa J. Idiopathic midline destructive disease (IMDD). American Journal of Clinical Pathology 77-.162-168, 1982.

[27] 27. Vexenat A, Rosa C, Cuba CC, Marsden PD. Recovery of Leishmania (Viannia) braziliensis from hepatic aspirates of the black plumed marmoset Callithrix penicillata Transactions of the Royal Society ofTropical Medicine and Hygiene 85:596, 1991.

[28] 28. Vieira JB, Laçerda MM, Marsden PD. National reporting of leishmaniasis: the Brazilian experience. Parasitology Today 6:339-340, 1990.

[29] 29. Zajtchuck JT, Casier JD, Netto EM, Grogl M, Neafie RC, Hessel CR, Magalhães AV, Marsden PD. Mucosal leishmaniasis in Brazil. Laryngoscope 99:925-939, 1989.